Application of two lines of chemotherapy: gemcitabine with nab-paclitaxel and liposomal irinotecan with 5-fluorouracil and leucovorin in patient with advanced pancreatic adenocarcinoma Case report

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Published: Jul 11, 2021
DOI: https://doi.org/10.24292/01.OR.123100721
Keywords:
advanced pancreatic cancer, gemcitabine in combination with nab-paclitaxel, liposomal irinotecan with 5-FU/LV

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Krystyna Ostrowska-Cichocka
Department of Clinical Oncology with the Subdivision of Daily Chemotherapy, Dr. Ewa Pilecka Memorial Bialystok Cancer Center
Marek Z. Wojtukiewicz
1. Department of Clinical Oncology with the Subdivision of Daily Chemotherapy, Dr. Ewa Pilecka Memorial Bialystok Cancer Center. 2. Department of Oncology, Medical University of Bialystok

Abstract

Pancreatic cancer is a disease with high mortality. It is predicted to become the second leading cause of cancer death in some regions of the world. Frequent diagnosis at an advanced stage contributes to 5-year survival at a highly unsatisfactory level of 2–9%. Due to the lack of early symptoms, nearly 80% of patients receive a diagnosis when distant metastases develop. So far, the most frequently used programs in the treatment of patients with pancreatic cancer in the stage of neoplastic spreading include: FOLFIRINOX (oxaliplatin, 5-fluorouracil, irinotecan, leucovorin), gemcitabine alone or in combination with nab-paclitaxel or erlotinib.


Based on the results of the phase III study NAPOLI-1, liposomal irinotecan in combination with 5-fluorouracil (5-FU) and leucovorin (LV ) was approved as the first regimen for use in the second or subsequent line of therapy in patients with advanced pancreatic cancer previously treated with gemcitabine. This paper presents a case of a patient with advanced pancreatic cancer who was treated with two lines of chemotherapy – gemcitabine in combination with nab-paclitaxel and liposomal irinotecan with 5-FU/LV . The treatment was well tolerated and was considered a valuable therapeutic option. A 2-year overall survival was obtained from the diagnosis of the disease.

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How to Cite
1.
Ostrowska-Cichocka K, Wojtukiewicz MZ. Application of two lines of chemotherapy: gemcitabine with nab-paclitaxel and liposomal irinotecan with 5-fluorouracil and leucovorin in patient with advanced pancreatic adenocarcinoma. OncoReview [Internet]. 2021Jul.11 [cited 2024Nov.24];11(3(43):68-2. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/1517
Issue
Vol 11 No 3(43) (2021)
Section
PERSONALIZED ONCOLOGY
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