Cefuroxime axetil – wide spectrum of indications. Why is it worth it? Review article

Abstract

Cefuroxime axetil is a prodrug – acetoxyethyl ester of cefuroxime, intended for oral administration. In vitro, the drug exhibits a broad spectrum of antibacterial activity. It is active against Gram-positive aerobic bacteria, Gram-negative aerobic bacteria and spirochetes (Borrelia burgdorferi). The broad spectrum of antibacterial activity means that cefuroxime axetil can be used in many indications in both adults and children. The diseases in which this antibiotic is recommended include: acute streptococcal pharyngitis and tonsillitis, bacterial sinusitis, acute otitis media, lower respiratory tract infections, urinary tract infection in the lower urinary tract, pyelonephritis, uncomplicated skin and soft tissue infections, bone and joint infections, early Lyme disease and perioperative prophylaxis. In adults, a single dose is 250–500 mg, in the pediatric population, the dosage depends on the child’s body weight, usually 10–15 mg/kg b.w. Cefuroxime is administered as a prodrug, so it disrupts the natural balance of intestinal microflora to a lesser extent – there is a lower risk of post-antibiotic diarrhea. There are no clinically significant interactions with other drugs. The availability of various preparations, easy dosing and relatively low price mean that cefuroxime axetil can be successfully used in many patients of different ages.