Azotan fentikonazolu w leczeniu infekcji pochwy i sromu Artykuł przeglądowy
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Opublikowane:
wrz 30, 2014
Słowa kluczowe:
azotan fentikonazolu, infekcja pochwy i sromu, leczenie
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Abstrakt
Infekcje pochwy i sromu (vulvovaginitis) są najczęstszą przyczyną zgłaszania się kobiet po poradę do ginekologa. Wiedza na temat właściwości leków stosowanych w leczeniu zakażeń pochwy i sromu pozwala lekarzowi na dostosowanie schematu terapeutycznego do indywidualnych potrzeb pacjentek. Azotan fentikonazolu jest nowoczesną opcją terapeutyczną w leczeniu infekcji pochwy i sromu. Krótko- i długoterminową efektywność terapeutyczną tego leku potwierdzono w licznych badaniach klinicznych. Dobra tolerancja, wysoka skuteczność i duża akceptacja fentikonazolu przez pacjentki czynią z niego doskonałe narzędzie do leczenia zakażeń pochwy i sromu.
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Jak cytować
Tomaszewski, J. (2014). Azotan fentikonazolu w leczeniu infekcji pochwy i sromu . Medycyna Faktów , 7(3(24), 59-65. Pobrano z https://journalsmededu.pl/index.php/jebm/article/view/2355
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Bibliografia
1. Tomaszewski J., Niemiec T.: Drożdżakowe zapalenie pochwy i sromu. W: Zakażenie w położnictwie i ginekologii. T. 1, T. Niemiec (red.), Gdańsk, ViaMedica 2009.
2. Tomaszewski J.: Leczenie nawrotowej postaci drożdżakowego zapalenia pochwy i sromu. Zakażenia 2011; 6; 94-99.
3. Fan A.P., Xue F.X.: Clinical characteristics of aerobic vaginitis and its mixed infections. Zhonghua Fu Chan Ke Za Zhi 2010; 45: 904-908.
4. Fan A., Yue Y., Geng N., Zhang H., Wang Y., Xue F.: Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings. Arch. Gynecol. Obstet. 2013; 287: 329-335.
5. Ventolini G., Baggish M.S.: Reccurent vulvovaginal candidiasis. Clin. Microbiol. Newsletters 2006; 28: 93-95.
6. Sobel J.D.: Vulvovaginal candidosis. Lancet 2007; 369: 1961-1971.
7. Spacek J., Buchta V., Jilek P. et al.: Clinical aspects and luteal phase assesment in patients with recurrent vulvovaginal candidiasis, Eur. J. Obstet. Gynecol. Reprod. Biol. 2007; 131: 198-202.
8. Genital Candidiasis. US DEPARTMENT OF HEALTH AND HUMAN SERVICES, Centres for Disease Control and Prevention (CDC), Division of Bacterial and Mycotic Diseases.
9. Mendling W.: Rezidivierende Vaginalinfektionen: Candidose, Bakterielle Vaginose. Der Gynäkologe 2009; 42: 766-771.
10. Anane S., Kaoech E., Zouari B. et al.: Les candidioses vulvovaginales: facteurs de risque et particularites cliniques et mycologiques. J. Mycol. Med. 2010; 20: 36-41.
11. Sherrard J., Donders G., White D. et al.: European (IUSTI/WHO) guideline on the management of vaginal discharge, 2011. Int. J. STD AIDS 2011; 22: 421-429.
12. Murina F., Graziottin A., Felice R., Di Francesco S., Mantegazza V.: Short-course treatment of vulvovaginal candidiasis: comparative study of fluconazole and intra-vaginal fenticonazole. Minerva Ginecol. 2012; 64: 89-94.
13. Stanowisko zespołu ekspertów Polskiego Towarzystwa Ginekologicznego w sprawie leczenia ostrego i nawrotowego grzybiczego zapalenia pochwy i sromu – stan wiedzy na 2008 r. Ginekol. Pol. 2008; 79: 638-652.
14. Lopez-Martinez R.: Candidosis, a new challenge. Clinics in Dermatology 2010; 28: 178-184.
15. Stanowisko zespołu ekspertów Polskiego Towarzystwa Ginekologicznego dotyczące etiopatogenezy i leczenia nawrotowej postaci drożdżakowego zapalenia pochwy i sromu. Ginekol. Pol. 2011; 82: 869-873.
16. Beggs W.: The effects of antifungal imidazoles on resting cells of Candida parapsilosis. IRCS Med. Sci. Libr. Compend. 1983; 11: 677-678.
17. Elliott K.: Managing patients with vulvovaginal candidiasis. Nurse Pract. 1998; 23: 44-51.
18. Watson M., Grimshaw J., Bond C. et al.: Oral versus intra-vaginal imidazole and triazole anti-fungal agents for the treatment on uncomplicated vulvovaginal candidiasis (thrush): a systematic review. BJOG. 2002; 109: 85-95.
19. LaFleur M., Kumamoto C.A., Lewis K.: Candida albicans biofilms produce antifungal-tolerant perister cells. Antimicrob. Agents Chemother. 2006; 50: 3839-3846.
20. Ejdys E., Rasztęborska A.N.: Rola biofilmu w przeżywalności i żywotności grzybów rodzaju Candida poza organizmem gospodarza. Mikologia Lekarska 2010; 17: 155-159.
21. Studd J.W., Dooley M.M., Welch C.C. et al.: Comparative clinical trial of fenticonazole ovule (600 mg) versus clotrimazole vaginal tablet (500 mg) in the treatment of symptomatic vaginal candidiasis. Curr. Med. Res. Opin. 1989; 11: 477-84 [a].
22. Studd J.W., Dooley M.M., Welch C.C., Vijayakanthan K., Mowat J.M., Wade A., Newell M.: Comparative clinical trial of fenticonazole ovule (600 mg) versus clotrimazole vaginal tablet (500 mg) in the treatment of symptomatic vaginal candidiasis. Curr. Med. Res. Opin. 1989; 11: 477-484 [b].
23. Angiolella L., De Bernardis F., Bromuro C., Mondello F., Ceddia T., Cassone A.: The effect of antimycotics on secretory acid proteinase of Candida albicans. J. Chemother. 1990; 2: 55-61.
24. Leiste D., Braun W., Fegeler W. et al.: A double-blind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses. Curr. Med. Res. Opin. 1989; 11: 567-575.
25. Halbe H.W., Hegg R., Fernandes C.E. et al.: Estudo da eficacia e tolerabilidade do fenticonazol no tratamento da vulvovaginete por candida albicans. Rev. Bras. Med. 2000; 57: 1306-1311.
26. Veraldi S., Milani R.: Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs 2008; 68: 2183-2194.
27. Veronese M., Beretoncini A., Monici Preti P.: Evaluation of the skin retention time of imidazole derivatives. Mykosen 1987; 30: 386-390.
28. Gorlero F., Sartani A., Cordaro C.I. et al.: Fenticonazole tissue levels after the application of 3 different dosage forms of vaginal ovules. Int. J. Clin. Pharmacol. Ther. Toxicol 1988; 26: 479-481.
29. De Bernardis F., Cassone A.: Comparison of the effects of fenticonazole a nd econazole on the aspartic proteinase secreted by Candida albicans. Contracept. Fertil. Sex. 1996; 24: 163-165.
30. Wiest W., Ruffmann R.: Short-term treatment of vaginal candidiasis with fenticonazole ovules: a three-dose schedule comparative trial. J. Int. Med. Res. 1987; 15: 319-325.
31. Živaljevic B., Golubovic I., Seratlic J. et al.: Efficiency of fenticonazole for the treatment of vaginal candidiasis. Srp. Arh. Celok. Lek. 2012; 140: 469-474.
32. Balaïsch J.: Evaluation of the time response of a single dose administration of fenticonazole nitrate. Contracept. Fertil. Sex. 1996; 24: 417-422.
33. Kovachev S., Nacheva A., Vacheva-Dobrevska R., Vasilev N.: Combined single-day treatment in acute vulvovaginal candidosis. Akush. Ginekol. 2009; 48: 18-23.
34. Lawrence A.G., Houang E.T., Hiscock E. et al.: Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets. Curr. Med. Res. Opin. 1990; 12(2): 114-120.
35. Graziani G., Cazzulani P., Barbadoro E.: Toxicological and pharmacological properties of fenticonazole, a new topical antimycotic. Arzneimittelforschung 1981; 31: 2145-2151.
36. Veronese M., Barzaghi D., Bertoncini A., Zadro M.: The Salmonella mutagenicity assay on fenticonazole, a new antifungal imidazole derivative. Arzneimittelforschung 1981; 31: 2140-2142.
37. Novelli A., Periti E., Massi G.B., Masi R., Mazzei T., Periti P.: Systemic absorption of 3H-fenticonazole after vaginal administration of 1 gram in patients. J. Chemother. 1991; 3: 23-27.
38. Fernández-Alba J., Valle-Gay A., Dibildox M., Vargas J.A., González J., García M., López L.H.: Fentimex Mexican Study Group: Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J. Chemother. 2004; 16(2): 179-186.
39. Naud P., Matos J., Hammes L. et al.: Efficacy and tolerability of fenticonazol for bacterial vaginosis treatment: double-blind study, randomized, prospective, compared to placebo. Rev. Bras. Med. 2003; 60: 67-70.
40. Munoz Reyes J.R., Villanueva Reynoso C., Ramos C.J. et al.: Efficacy and tolerance of 200 mg of fenticonazole versus 400 mg of miconazole in the intravaginal treatment of mycotic vulvovaginitis. Ginecol. Obstet. Mex. 2002; 70: 59-65.
41. Scalambrino S., Colombo M., Pellegrino A. et al.: Efficacy and tolerability of intravaginal fenticonazole single therapeutic shot in low-recurrent vaginal trichomoniasis and candidiasis. Giorn. Ital. Mal. Inf. 1996; 2: 37-40.
42. Gorlero F., Macchiavello S., Pellegatta L. et al.: Evaluation of the efficacy and tolerability of two different dosages of fenticonazole vaginal ovules (600 mg and 1000 mg) in patients with vaginal trichomoniasis: a controlled, double-blind, randomized clinical trial versus placebo. Curr. Ther. Res. Clin. Exp. 1994; 55: 510-518.
43. Gorlero F., Bosco P., Barbieri M. et al.: Fenticonazole ovules in the treatment of vaginal Trichomonas infections: a double- blind randomized pilot clinical trial. Curr. Ther. Res. Clin. Exp. 1992; 51: 367-376.
44. Bukovsky I., Schneider D., Arieli S. et al.: Fenticonazole in the treatment of vaginal trichomoniasis and vaginal mixed infections. Adv. Ther. 1991; 8: 166-171.
45. Schneider D., Caspi E., Arieli S. et al.: Fenticonazole in the treatment of vaginal candidiasis. Adv. Ther. 1990; 7: 355-361.
46. Wiest W., Azzollini E., Ruffmann R.: Comparison of single administration with an ovule of 600 mg fenticonazole versus a 500 mg clotrimazole vaginal pessary in the treatment of vaginal candidiasis. J. Int. Med. Res .1989; 17: 369-372.
47. De Cecco L., Gorlero F., Marre Brunenghi M.C. et al.: Studio multicentrico sull’efficacia e tollerabilita del fenticonazolo nel trattamento delle vulvovaginiti da candida. Int. J. Drug. Ther. 1988; 5: 296-301.
48. Sartani A., Cordaro C.I., Panconesi E.: A multicenter trial with a new imidazole derivative, fenticonazole, in superficial fungal skin infections. Curr. Ther. Res. Clin. Exp. 1988; 43: 1194-1203.
49. Sartani A., Cordaro C., Adinolfi G. et al.: Short-term treatment of vaginal candidiasis: results of a multi-center study. Riv. Ost. Gin. Perin 1988; 3: 184-189.
50. Scienza G., Bulgheroni C., Confalonieri C.: Vaginiti recidivanti efficacia e tollerabilita della terapia locale con fenticonazolo. G. Ital. Ost. Gin. 1987; 9: 758-760.
51. Brewster E., Preti P.M., Ruffmann R., Studd J.: Effect of fenticonazole in vaginal candidiasis: a double-blind clinical trial versus clotrimazole. J. Int. Med. Res. 1986; 14: 306-310.
2. Tomaszewski J.: Leczenie nawrotowej postaci drożdżakowego zapalenia pochwy i sromu. Zakażenia 2011; 6; 94-99.
3. Fan A.P., Xue F.X.: Clinical characteristics of aerobic vaginitis and its mixed infections. Zhonghua Fu Chan Ke Za Zhi 2010; 45: 904-908.
4. Fan A., Yue Y., Geng N., Zhang H., Wang Y., Xue F.: Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings. Arch. Gynecol. Obstet. 2013; 287: 329-335.
5. Ventolini G., Baggish M.S.: Reccurent vulvovaginal candidiasis. Clin. Microbiol. Newsletters 2006; 28: 93-95.
6. Sobel J.D.: Vulvovaginal candidosis. Lancet 2007; 369: 1961-1971.
7. Spacek J., Buchta V., Jilek P. et al.: Clinical aspects and luteal phase assesment in patients with recurrent vulvovaginal candidiasis, Eur. J. Obstet. Gynecol. Reprod. Biol. 2007; 131: 198-202.
8. Genital Candidiasis. US DEPARTMENT OF HEALTH AND HUMAN SERVICES, Centres for Disease Control and Prevention (CDC), Division of Bacterial and Mycotic Diseases.
9. Mendling W.: Rezidivierende Vaginalinfektionen: Candidose, Bakterielle Vaginose. Der Gynäkologe 2009; 42: 766-771.
10. Anane S., Kaoech E., Zouari B. et al.: Les candidioses vulvovaginales: facteurs de risque et particularites cliniques et mycologiques. J. Mycol. Med. 2010; 20: 36-41.
11. Sherrard J., Donders G., White D. et al.: European (IUSTI/WHO) guideline on the management of vaginal discharge, 2011. Int. J. STD AIDS 2011; 22: 421-429.
12. Murina F., Graziottin A., Felice R., Di Francesco S., Mantegazza V.: Short-course treatment of vulvovaginal candidiasis: comparative study of fluconazole and intra-vaginal fenticonazole. Minerva Ginecol. 2012; 64: 89-94.
13. Stanowisko zespołu ekspertów Polskiego Towarzystwa Ginekologicznego w sprawie leczenia ostrego i nawrotowego grzybiczego zapalenia pochwy i sromu – stan wiedzy na 2008 r. Ginekol. Pol. 2008; 79: 638-652.
14. Lopez-Martinez R.: Candidosis, a new challenge. Clinics in Dermatology 2010; 28: 178-184.
15. Stanowisko zespołu ekspertów Polskiego Towarzystwa Ginekologicznego dotyczące etiopatogenezy i leczenia nawrotowej postaci drożdżakowego zapalenia pochwy i sromu. Ginekol. Pol. 2011; 82: 869-873.
16. Beggs W.: The effects of antifungal imidazoles on resting cells of Candida parapsilosis. IRCS Med. Sci. Libr. Compend. 1983; 11: 677-678.
17. Elliott K.: Managing patients with vulvovaginal candidiasis. Nurse Pract. 1998; 23: 44-51.
18. Watson M., Grimshaw J., Bond C. et al.: Oral versus intra-vaginal imidazole and triazole anti-fungal agents for the treatment on uncomplicated vulvovaginal candidiasis (thrush): a systematic review. BJOG. 2002; 109: 85-95.
19. LaFleur M., Kumamoto C.A., Lewis K.: Candida albicans biofilms produce antifungal-tolerant perister cells. Antimicrob. Agents Chemother. 2006; 50: 3839-3846.
20. Ejdys E., Rasztęborska A.N.: Rola biofilmu w przeżywalności i żywotności grzybów rodzaju Candida poza organizmem gospodarza. Mikologia Lekarska 2010; 17: 155-159.
21. Studd J.W., Dooley M.M., Welch C.C. et al.: Comparative clinical trial of fenticonazole ovule (600 mg) versus clotrimazole vaginal tablet (500 mg) in the treatment of symptomatic vaginal candidiasis. Curr. Med. Res. Opin. 1989; 11: 477-84 [a].
22. Studd J.W., Dooley M.M., Welch C.C., Vijayakanthan K., Mowat J.M., Wade A., Newell M.: Comparative clinical trial of fenticonazole ovule (600 mg) versus clotrimazole vaginal tablet (500 mg) in the treatment of symptomatic vaginal candidiasis. Curr. Med. Res. Opin. 1989; 11: 477-484 [b].
23. Angiolella L., De Bernardis F., Bromuro C., Mondello F., Ceddia T., Cassone A.: The effect of antimycotics on secretory acid proteinase of Candida albicans. J. Chemother. 1990; 2: 55-61.
24. Leiste D., Braun W., Fegeler W. et al.: A double-blind clinical trial of fenticonazole (2%) spray versus naftifine (1%) spray in patients with cutaneous mycoses. Curr. Med. Res. Opin. 1989; 11: 567-575.
25. Halbe H.W., Hegg R., Fernandes C.E. et al.: Estudo da eficacia e tolerabilidade do fenticonazol no tratamento da vulvovaginete por candida albicans. Rev. Bras. Med. 2000; 57: 1306-1311.
26. Veraldi S., Milani R.: Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs 2008; 68: 2183-2194.
27. Veronese M., Beretoncini A., Monici Preti P.: Evaluation of the skin retention time of imidazole derivatives. Mykosen 1987; 30: 386-390.
28. Gorlero F., Sartani A., Cordaro C.I. et al.: Fenticonazole tissue levels after the application of 3 different dosage forms of vaginal ovules. Int. J. Clin. Pharmacol. Ther. Toxicol 1988; 26: 479-481.
29. De Bernardis F., Cassone A.: Comparison of the effects of fenticonazole a nd econazole on the aspartic proteinase secreted by Candida albicans. Contracept. Fertil. Sex. 1996; 24: 163-165.
30. Wiest W., Ruffmann R.: Short-term treatment of vaginal candidiasis with fenticonazole ovules: a three-dose schedule comparative trial. J. Int. Med. Res. 1987; 15: 319-325.
31. Živaljevic B., Golubovic I., Seratlic J. et al.: Efficiency of fenticonazole for the treatment of vaginal candidiasis. Srp. Arh. Celok. Lek. 2012; 140: 469-474.
32. Balaïsch J.: Evaluation of the time response of a single dose administration of fenticonazole nitrate. Contracept. Fertil. Sex. 1996; 24: 417-422.
33. Kovachev S., Nacheva A., Vacheva-Dobrevska R., Vasilev N.: Combined single-day treatment in acute vulvovaginal candidosis. Akush. Ginekol. 2009; 48: 18-23.
34. Lawrence A.G., Houang E.T., Hiscock E. et al.: Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets. Curr. Med. Res. Opin. 1990; 12(2): 114-120.
35. Graziani G., Cazzulani P., Barbadoro E.: Toxicological and pharmacological properties of fenticonazole, a new topical antimycotic. Arzneimittelforschung 1981; 31: 2145-2151.
36. Veronese M., Barzaghi D., Bertoncini A., Zadro M.: The Salmonella mutagenicity assay on fenticonazole, a new antifungal imidazole derivative. Arzneimittelforschung 1981; 31: 2140-2142.
37. Novelli A., Periti E., Massi G.B., Masi R., Mazzei T., Periti P.: Systemic absorption of 3H-fenticonazole after vaginal administration of 1 gram in patients. J. Chemother. 1991; 3: 23-27.
38. Fernández-Alba J., Valle-Gay A., Dibildox M., Vargas J.A., González J., García M., López L.H.: Fentimex Mexican Study Group: Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J. Chemother. 2004; 16(2): 179-186.
39. Naud P., Matos J., Hammes L. et al.: Efficacy and tolerability of fenticonazol for bacterial vaginosis treatment: double-blind study, randomized, prospective, compared to placebo. Rev. Bras. Med. 2003; 60: 67-70.
40. Munoz Reyes J.R., Villanueva Reynoso C., Ramos C.J. et al.: Efficacy and tolerance of 200 mg of fenticonazole versus 400 mg of miconazole in the intravaginal treatment of mycotic vulvovaginitis. Ginecol. Obstet. Mex. 2002; 70: 59-65.
41. Scalambrino S., Colombo M., Pellegrino A. et al.: Efficacy and tolerability of intravaginal fenticonazole single therapeutic shot in low-recurrent vaginal trichomoniasis and candidiasis. Giorn. Ital. Mal. Inf. 1996; 2: 37-40.
42. Gorlero F., Macchiavello S., Pellegatta L. et al.: Evaluation of the efficacy and tolerability of two different dosages of fenticonazole vaginal ovules (600 mg and 1000 mg) in patients with vaginal trichomoniasis: a controlled, double-blind, randomized clinical trial versus placebo. Curr. Ther. Res. Clin. Exp. 1994; 55: 510-518.
43. Gorlero F., Bosco P., Barbieri M. et al.: Fenticonazole ovules in the treatment of vaginal Trichomonas infections: a double- blind randomized pilot clinical trial. Curr. Ther. Res. Clin. Exp. 1992; 51: 367-376.
44. Bukovsky I., Schneider D., Arieli S. et al.: Fenticonazole in the treatment of vaginal trichomoniasis and vaginal mixed infections. Adv. Ther. 1991; 8: 166-171.
45. Schneider D., Caspi E., Arieli S. et al.: Fenticonazole in the treatment of vaginal candidiasis. Adv. Ther. 1990; 7: 355-361.
46. Wiest W., Azzollini E., Ruffmann R.: Comparison of single administration with an ovule of 600 mg fenticonazole versus a 500 mg clotrimazole vaginal pessary in the treatment of vaginal candidiasis. J. Int. Med. Res .1989; 17: 369-372.
47. De Cecco L., Gorlero F., Marre Brunenghi M.C. et al.: Studio multicentrico sull’efficacia e tollerabilita del fenticonazolo nel trattamento delle vulvovaginiti da candida. Int. J. Drug. Ther. 1988; 5: 296-301.
48. Sartani A., Cordaro C.I., Panconesi E.: A multicenter trial with a new imidazole derivative, fenticonazole, in superficial fungal skin infections. Curr. Ther. Res. Clin. Exp. 1988; 43: 1194-1203.
49. Sartani A., Cordaro C., Adinolfi G. et al.: Short-term treatment of vaginal candidiasis: results of a multi-center study. Riv. Ost. Gin. Perin 1988; 3: 184-189.
50. Scienza G., Bulgheroni C., Confalonieri C.: Vaginiti recidivanti efficacia e tollerabilita della terapia locale con fenticonazolo. G. Ital. Ost. Gin. 1987; 9: 758-760.
51. Brewster E., Preti P.M., Ruffmann R., Studd J.: Effect of fenticonazole in vaginal candidiasis: a double-blind clinical trial versus clotrimazole. J. Int. Med. Res. 1986; 14: 306-310.