Preferential cyclooxygenase 2 inhibitors in postoperative pain treatment Review article

Main Article Content

Hanna Misiołek
Maja Copik

Abstract

Accurate postoperative pain management is crucial for successful modern surgery. The most commonly used currently is the concept of multimodal analgesia which means combining different kinds of anaesthetic techniques with various groups of analgesic drugs. To make postoperative pain management more efficient guidelines are developed. One of the groups of drugs listed in current polish postoperative pain management guidelines are nonsteroidal anti-inflammatory drugs (NSAIDS) containing also preferential cyclooxygenase 2 inhibitors (COX-2) like nimesulide and meloxicam. Those drugs are available in different oral formulations and because of their way of action can be used in many specific groups of patients suffering from postoperative pain both in hospitals and in ambulatory surgery.

Article Details

How to Cite
Misiołek, H., & Copik, M. (2015). Preferential cyclooxygenase 2 inhibitors in postoperative pain treatment. Medycyna Faktow (J EBM), 8(1(26), 79-84. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2328
Section
Articles

References

1. Misiołek H., Cettler M., Woroń J. et al.: The 2014 guidelines for post-operative pain management. Anaesth. Intens. Ther. 2014; 46: 221-244.
2. Rainsford K.D.: Nimesulide: actions and use Birkhaeuser Verlag. Basel-Boston-Berlin 2005.
3. Klimiuk A.P., Sierakowski S.: Zastosowanie nimesulidu w chorobach reumatycznych. Nowa Medycyna 2/2002.
4. Bianchi M., Broggini M.: Anti-hyperalgesic effects of nimesulide: studies in rats and humans. Int. J. Clin. Pract. supl. 2002; (128): 11-19.
5. Castellsague J., Pisa F., Rosole V. et al.: Risk of upper gastrointestinal complications in a cohort of users of nimesulide and other nonsteroidal antiinflammatory drugs in Friuli Venezia Giulia, Italy. Pharmacoepidemiol. Drug Saf. 2013; 22(4): 365-375.
6. Misiołek H., Copik M.: Meloksikam ODT: nowe podejście do starego problemu. Medycyna i Życie 2014; 3-4.
7. Asghar W., Jamali F.: The effect of COX-2-selective meloxicam on the myocardial, vascular and renal risks: a systematic review. Inflammopharmacology 2014; 17 [Epub ahead of print].
8. McGettigan P., Henry D.: Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med. 2011; 8(9).
9. Atkinson T.J., Fudin J., Jahn H.L. et al.: What’s new in NSAID pharmacotherapy: oral agents to injectables. Pain Med. 2013; 14(supl. 1): S11-7.
10. Villalba B.T., Ianiski F.R., Wilhelm E.A. et al.: Meloxicam-loaded nanocapsules have antinociceptive and antiedematogenic effects in acute models of nociception. Pain. Med. 2013; 14(supl. 1): S11-7.