Witamina C w codziennej praktyce lekarskiej – fakty i mity Artykuł przeglądowy
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Opublikowane:
gru 31, 2019
Słowa kluczowe:
witamina C, infekcja, przeziębienie, DNA
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Abstrakt
Leki i suplementy diety dostępne bez recepty stosowane są nie tylko w samoleczeniu na podstawie doświadczenia życiowego i reklam medialnych, ale również zalecane przez lekarzy w codziennej praktyce. W XXI w. oprócz książkowej wiedzy i doświadczenia klinicznego lekarze dostali do ręki potężne narzędzie sankcjonujące podejmowanie takich, a nie innych decyzji – Evidence Based Medicine. W niniejszym opracowaniu chcielibyśmy się przyjrzeć, jak w świetle medycyny opartej na faktach wygląda pozycja stosowanych od lat w różnych wskazaniach preparatów witaminy C.
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Jak cytować
Wójcik, W., & Śliż , D. (2019). Witamina C w codziennej praktyce lekarskiej – fakty i mity. Medycyna Faktów , 12(4(45), 307-314. https://doi.org/10.24292/01.MF.0419.1
Numer
Dział
Artykuły
Copyright © by Medical Education. All rights reserved.
Bibliografia
1. Bender D.A.: Nutritional Biochemistry of the Vitamins. Cambridge University Press, Cambridge 2003.
2. Jameson J.L., Fauci A.S., Kasper D.L. et al.: Harrison’s Principles of Internal Medicine. 20th ed. McGraw Hill Education, New York 2018.
3. Svirbely J.L., Szent-Györgyi A.: The chemical nature of vitamin C. Biochem. J. 1932; 26(3): 865-870.
4. Norum K.R., Grav H.J.: Axel Holst and Theodor Frolich – pioneers in the combat of scurvy. Tidsskr. Nor. Laegeforen. 2002; 122(17): 1686-1687.
5. Ritzel G.: Kritische Beurteilung des Vitamins C als Prophylacticum und Therapeuticum der Erkältungskrankheiten. Helv. Med. Acta 1961; 28: 63-68.
6. Pauling L.: Ascorbic acid and the common cold. Am. J. Clin. Nutr. 1971; 24: 1294-1299.
7. Chalmers T.C.: Effects of ascorbic acid on the common cold. An evaluation of the evidence. Am. J. Med. 1975; 58: 532-536.
8. Dykes M.H.M., Meier P.: Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity. JAMA 1975; 231: 1073-1079.
9. Karlowski T.R., Chalmers T.C., Frenkel L.D. et al.: Ascorbic acid for the common cold. A prophylactic and therapeutic trial. JAMA 1975; 231: 1038-1042.
10. Hemilä H.: Vitamin C supplementation and the common cold – was Linus Pauling right or wrong? Int. J. Vit. Nutr. Res. 1997; 67: 329-335.
11. Hemilä H., Chalker E.: Vitamin C for Preventing and Treating the Common Cold. Cochrane Database Syst. Rev. 2013; (1): CD000980.
12. De la Fuente M., Ferrandez M.D., Burgos M.S. et al.: Immune function in aged women is improved by ingestion of vitamins C and E. Can. J. Physiol. Pharmacol. 1998; 76: 373-380.
13. Bozonet S.M., Carr A.C., Pullar J.M., Vissers M.C.M.: Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients 2015; 7: 2574-2588.
14. Carr A.C., Maggini S.: Vitamin C and Immune Function. Nutrients 2017; 9(11). pii: E1211.
15. Sies H.: Total Antioxidant Capacity: Appraisal of a Concept. J. Nutr. 2007; 137(6): 1493-1495.
16. Sezikli M., Cetinkaya Z.A., Güzelbulut F. et al.: Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity. Clin. Res. Hepatol. Gastroenterol. 2011; 35: 745-749.
17. Dey S., Bishayi B.: Killing of s. aureus in murine peritoneal macrophages by ascorbic acid along with antibiotics chloramphenicol or ofloxacin: Correlation with inflammation. Microb. Pathog. 2017 Published online 2017 Dec 20.
18. Giladi A.M., Dossett L.A., Fleming S.B. et al.: High-dose antioxidant administration is associated with a reduction in post-injury complications in critically ill trauma patients. Injury 2011; 42: 78-82.
19. Collier B.R., Giladi A., Dossett L.A. et al.: Impact of high-dose antioxidants on outcomes in acutely injured patients. J. Parenter. Enteral. Nutr. 2008; 32(4): 384-388.
20. Duthie S.J., Ma A., Ross M.A., Collins A.R.: Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 1996; 56: 1291-1295.
21. Tao S.M., Zhou F., Schoepf U.J. et al.: The effect of prophylactic oral vitamin C use on DNA double-strand breaks after abdominal contrast-enhanced CT: A preliminary study. Eur. J. Radiol. 2019; 117: 69-74.
22. Błasiak J., Kowalik J.: Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate. Acta Biochim. Pol. 2001; 48(1): 233-240.
23. Das Roy L., Giri S., Singh S., Giri A.: Effects of radiation and vitamin C treatment on metronidazole genotoxicity in mice. Mutat. Res. 2013; 753: 65-71.
24. Bo Y., Lu Y., Zhao Y. et al.: Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. Int. J. Cancer 2016; 138(8): 1843-1850.
25. Hoang B.V., Lee J., Choi I.J. et al.: Effect of dietary vitamin C on gastric cancer risk in the Korean population. World J. Gastroenterol. 2016; 22(27): 6257-6267.
26. Zhang Z.W., Abdullahi M., Farthing M.J.: Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori. Gut. 2002; 50(2): 165-169.
27. Tannenbaum S.R.: Preventive action of vitamin C on nitrosamine formation. Int. J. Vitam. Nutr. Res. Suppl. 1989; 30: 109-113.
28. Guz J., Oliński R.: The role of vitamin C in epigenetic regulation. Postepy Hig. Med. Dosw. Online 2017; 71: 747-760.
29. Shenoy N., Bhagat T.D., Cheville J. et al.: Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma. J. Clin. Invest. 2019; 130: 1612-1625.
30. Gerecke C., Schumacher F., Edlich A. et al.: Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget 2018; 9: 32822-32840.
31. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission. EFSA Journal 2009; 7(9): 1226.
32. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy-yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8(10): 1815.
33. Waśkiewicz A.: Jakość żywienia i poziom wiedzy zdrowotnej u młodych dorosłych Polaków – badanie WOBASZ. Probl. Hig. Epidemiol. 2010; 91(2): 233-237.
34. Schleicher R.L., Carroll M.D., Ford E.S., Lacher DA.: Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am. J. Clin. Nutr. 2009; 90(5): 1252-1263.
35. Masadeh M.M., Alzoubi K.H., Al-Azzam S.I. et al.: Ciprofloxacin-Induced Antibacterial Activity Is Atteneuated by Pretreatment with Antioxidant Agents. Pathogens 2016; 5(1): 28. DOI: 10.3390/pathogens5010028.
36. Hemilä H.: Vitamin C and Infections. Nutrients 2017; 9: 339.
37. Vasudevan S., Hirsch I.B.: Interference of intravenous vitamin C with blood glucose testing. Diabetes Care 2014; 37(5): e93-94.
38. Sharma E., Resta C., Park P.: A Case of Factitious Hyperglycemia in a Patient on Intravenous Ascorbic Acid. Case Rep. Endocrinol. 2018; 2018: 7063137.
39. Ashor A.W., Werner A.D., Lara J. et al.: Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials. Eur. J. Clin. Nutr. 2017; 71(12): 1371-1380.
40. Curhan G., Willett W., Rimm E., Stampfer M.: A prospective study of the intake of vitamin C and vitamin B6 and the risk of kidney stones in men. J. Urol. 1996; 155: 1847-1851.
41. Curhan G.C., Willett W.C., Speizer F.E., Stampfer M.J.: Intake of vitamins B6 and C and the risk of kidney stones in women. J. Am. Soc. Nephrol. 1999; 10: 840-845.
2. Jameson J.L., Fauci A.S., Kasper D.L. et al.: Harrison’s Principles of Internal Medicine. 20th ed. McGraw Hill Education, New York 2018.
3. Svirbely J.L., Szent-Györgyi A.: The chemical nature of vitamin C. Biochem. J. 1932; 26(3): 865-870.
4. Norum K.R., Grav H.J.: Axel Holst and Theodor Frolich – pioneers in the combat of scurvy. Tidsskr. Nor. Laegeforen. 2002; 122(17): 1686-1687.
5. Ritzel G.: Kritische Beurteilung des Vitamins C als Prophylacticum und Therapeuticum der Erkältungskrankheiten. Helv. Med. Acta 1961; 28: 63-68.
6. Pauling L.: Ascorbic acid and the common cold. Am. J. Clin. Nutr. 1971; 24: 1294-1299.
7. Chalmers T.C.: Effects of ascorbic acid on the common cold. An evaluation of the evidence. Am. J. Med. 1975; 58: 532-536.
8. Dykes M.H.M., Meier P.: Ascorbic acid and the common cold. Evaluation of its efficacy and toxicity. JAMA 1975; 231: 1073-1079.
9. Karlowski T.R., Chalmers T.C., Frenkel L.D. et al.: Ascorbic acid for the common cold. A prophylactic and therapeutic trial. JAMA 1975; 231: 1038-1042.
10. Hemilä H.: Vitamin C supplementation and the common cold – was Linus Pauling right or wrong? Int. J. Vit. Nutr. Res. 1997; 67: 329-335.
11. Hemilä H., Chalker E.: Vitamin C for Preventing and Treating the Common Cold. Cochrane Database Syst. Rev. 2013; (1): CD000980.
12. De la Fuente M., Ferrandez M.D., Burgos M.S. et al.: Immune function in aged women is improved by ingestion of vitamins C and E. Can. J. Physiol. Pharmacol. 1998; 76: 373-380.
13. Bozonet S.M., Carr A.C., Pullar J.M., Vissers M.C.M.: Enhanced human neutrophil vitamin C status, chemotaxis and oxidant generation following dietary supplementation with vitamin C-rich SunGold kiwifruit. Nutrients 2015; 7: 2574-2588.
14. Carr A.C., Maggini S.: Vitamin C and Immune Function. Nutrients 2017; 9(11). pii: E1211.
15. Sies H.: Total Antioxidant Capacity: Appraisal of a Concept. J. Nutr. 2007; 137(6): 1493-1495.
16. Sezikli M., Cetinkaya Z.A., Güzelbulut F. et al.: Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity. Clin. Res. Hepatol. Gastroenterol. 2011; 35: 745-749.
17. Dey S., Bishayi B.: Killing of s. aureus in murine peritoneal macrophages by ascorbic acid along with antibiotics chloramphenicol or ofloxacin: Correlation with inflammation. Microb. Pathog. 2017 Published online 2017 Dec 20.
18. Giladi A.M., Dossett L.A., Fleming S.B. et al.: High-dose antioxidant administration is associated with a reduction in post-injury complications in critically ill trauma patients. Injury 2011; 42: 78-82.
19. Collier B.R., Giladi A., Dossett L.A. et al.: Impact of high-dose antioxidants on outcomes in acutely injured patients. J. Parenter. Enteral. Nutr. 2008; 32(4): 384-388.
20. Duthie S.J., Ma A., Ross M.A., Collins A.R.: Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 1996; 56: 1291-1295.
21. Tao S.M., Zhou F., Schoepf U.J. et al.: The effect of prophylactic oral vitamin C use on DNA double-strand breaks after abdominal contrast-enhanced CT: A preliminary study. Eur. J. Radiol. 2019; 117: 69-74.
22. Błasiak J., Kowalik J.: Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate. Acta Biochim. Pol. 2001; 48(1): 233-240.
23. Das Roy L., Giri S., Singh S., Giri A.: Effects of radiation and vitamin C treatment on metronidazole genotoxicity in mice. Mutat. Res. 2013; 753: 65-71.
24. Bo Y., Lu Y., Zhao Y. et al.: Association between dietary vitamin C intake and risk of esophageal cancer: A dose-response meta-analysis. Int. J. Cancer 2016; 138(8): 1843-1850.
25. Hoang B.V., Lee J., Choi I.J. et al.: Effect of dietary vitamin C on gastric cancer risk in the Korean population. World J. Gastroenterol. 2016; 22(27): 6257-6267.
26. Zhang Z.W., Abdullahi M., Farthing M.J.: Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori. Gut. 2002; 50(2): 165-169.
27. Tannenbaum S.R.: Preventive action of vitamin C on nitrosamine formation. Int. J. Vitam. Nutr. Res. Suppl. 1989; 30: 109-113.
28. Guz J., Oliński R.: The role of vitamin C in epigenetic regulation. Postepy Hig. Med. Dosw. Online 2017; 71: 747-760.
29. Shenoy N., Bhagat T.D., Cheville J. et al.: Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma. J. Clin. Invest. 2019; 130: 1612-1625.
30. Gerecke C., Schumacher F., Edlich A. et al.: Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget 2018; 9: 32822-32840.
31. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non-haem iron absorption (ID 132, 147), energy-yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission. EFSA Journal 2009; 7(9): 1226.
32. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy-yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8(10): 1815.
33. Waśkiewicz A.: Jakość żywienia i poziom wiedzy zdrowotnej u młodych dorosłych Polaków – badanie WOBASZ. Probl. Hig. Epidemiol. 2010; 91(2): 233-237.
34. Schleicher R.L., Carroll M.D., Ford E.S., Lacher DA.: Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am. J. Clin. Nutr. 2009; 90(5): 1252-1263.
35. Masadeh M.M., Alzoubi K.H., Al-Azzam S.I. et al.: Ciprofloxacin-Induced Antibacterial Activity Is Atteneuated by Pretreatment with Antioxidant Agents. Pathogens 2016; 5(1): 28. DOI: 10.3390/pathogens5010028.
36. Hemilä H.: Vitamin C and Infections. Nutrients 2017; 9: 339.
37. Vasudevan S., Hirsch I.B.: Interference of intravenous vitamin C with blood glucose testing. Diabetes Care 2014; 37(5): e93-94.
38. Sharma E., Resta C., Park P.: A Case of Factitious Hyperglycemia in a Patient on Intravenous Ascorbic Acid. Case Rep. Endocrinol. 2018; 2018: 7063137.
39. Ashor A.W., Werner A.D., Lara J. et al.: Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials. Eur. J. Clin. Nutr. 2017; 71(12): 1371-1380.
40. Curhan G., Willett W., Rimm E., Stampfer M.: A prospective study of the intake of vitamin C and vitamin B6 and the risk of kidney stones in men. J. Urol. 1996; 155: 1847-1851.
41. Curhan G.C., Willett W.C., Speizer F.E., Stampfer M.J.: Intake of vitamins B6 and C and the risk of kidney stones in women. J. Am. Soc. Nephrol. 1999; 10: 840-845.