Co dla kardiologa oznacza badanie EMPA-REG Outcome? Artykuł przeglądowy
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Opublikowane:
gru 31, 2020
Słowa kluczowe:
empagliflozyna, gliflozyny, inhibitory SGLT2, cukrzyca typu 2, śmiertelność całkowita
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Abstrakt
Większość obecnie stosowanych w cukrzycy leków wpływa jedynie na zmniejszenie ryzyka powikłań makronaczyniowych. Efekt ten w niewielkim stopniu przekłada się na zmniejszenie śmiertelności całkowitej. W pracy opisano empagliflozynę – pierwszy lek, który zmniejsza śmiertelność całkowitą u chorych na cukrzycę z wysokim ryzykiem sercowo-naczyniowym.
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Jak cytować
Gaciong , Z., & Dzida , G. (2020). Co dla kardiologa oznacza badanie EMPA-REG Outcome? . Medycyna Faktów , 13(4(49), 399-402. https://doi.org/10.24292/01.MF.0420.3
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Artykuły
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Bibliografia
1. Gæde P, Oellgaard J, Carstensen B et al. Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial. Diabetologia. 2016; 59: 2298-307.
2. Zinman B, Wanner C, Lachin JM et al. EMPA-REG OUTCOME Investigators: Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes N Engl J Med. 2015; 373: 2117-28.
3. Wanner C, Inzucchi SE, Lachin JM et al. EMPA-REG OUTCOME Investigators: Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes N Engl J Med. 2016; 375: 323-34.
4. Verma S, Mazer CD, Al-Omran M et al. Cardiovascular Outcomes and Safety of Empagliflozin in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: A Subanalysis of EMPA-REG OUTCOME. Circulation. 2018; 137: 405-7.
5. Wanner C, Lachin JM, Inzucchi SE et al. EMPA-REG OUTCOME Investigators: Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease. Circulation. 2018; 137: 119-29.
6. Verma S, Mazer CD, Fitchett D et al. Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial. Diabetologia. 2018; 61: 1712-23.
7. Standards of Medical Care in Diabetes. Diabetes Care 2019; 42(suppl 1): S1-S2.
8. Zalecenia kliniczne dotyczące postępowania u chorych na cukrzycę 2019. Stanowisko Polskiego Towarzystwa Diabetologicznego.
9. Abdul-Ghani M, Del Prato S, Chilton R et al. SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care. 2016; 39: 717-25.
10. Mora-Fernández C, Domínguez-Pimentel V, de Fuentes MM. Diabetic kidney disease: from physiology to therapeutics. J Physiol. 2014; 592: 3997-4012.
11. Toth-Manikowski S, Atta MG. Diabetic kidney disease: pathophysiology and therapeutic targets. J Diabetes Res. 2015; 2015: 697010.
12. Corriere M, Rooparinesingh N, Kalyani RR. Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden. Curr Diab Rep. 2013; 13: 805-13.
13. Dieter BP, Alicic RZ, Meek RL. Novel therapies for diabetic kidney disease: storied past and forward paths. Diabetes Spectr. 2015; 28: 167-74.
14. Altemtam N, Russell J, El Nahas M. A study of the natural history of diabetic kidney disease (DKD). Nephrol Dial Transplant. 2012; 27: 1847-54.
2. Zinman B, Wanner C, Lachin JM et al. EMPA-REG OUTCOME Investigators: Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes N Engl J Med. 2015; 373: 2117-28.
3. Wanner C, Inzucchi SE, Lachin JM et al. EMPA-REG OUTCOME Investigators: Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes N Engl J Med. 2016; 375: 323-34.
4. Verma S, Mazer CD, Al-Omran M et al. Cardiovascular Outcomes and Safety of Empagliflozin in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: A Subanalysis of EMPA-REG OUTCOME. Circulation. 2018; 137: 405-7.
5. Wanner C, Lachin JM, Inzucchi SE et al. EMPA-REG OUTCOME Investigators: Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease. Circulation. 2018; 137: 119-29.
6. Verma S, Mazer CD, Fitchett D et al. Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial. Diabetologia. 2018; 61: 1712-23.
7. Standards of Medical Care in Diabetes. Diabetes Care 2019; 42(suppl 1): S1-S2.
8. Zalecenia kliniczne dotyczące postępowania u chorych na cukrzycę 2019. Stanowisko Polskiego Towarzystwa Diabetologicznego.
9. Abdul-Ghani M, Del Prato S, Chilton R et al. SGLT2 inhibitors and cardiovascular risk: lessons learned from the EMPA-REG OUTCOME study. Diabetes Care. 2016; 39: 717-25.
10. Mora-Fernández C, Domínguez-Pimentel V, de Fuentes MM. Diabetic kidney disease: from physiology to therapeutics. J Physiol. 2014; 592: 3997-4012.
11. Toth-Manikowski S, Atta MG. Diabetic kidney disease: pathophysiology and therapeutic targets. J Diabetes Res. 2015; 2015: 697010.
12. Corriere M, Rooparinesingh N, Kalyani RR. Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden. Curr Diab Rep. 2013; 13: 805-13.
13. Dieter BP, Alicic RZ, Meek RL. Novel therapies for diabetic kidney disease: storied past and forward paths. Diabetes Spectr. 2015; 28: 167-74.
14. Altemtam N, Russell J, El Nahas M. A study of the natural history of diabetic kidney disease (DKD). Nephrol Dial Transplant. 2012; 27: 1847-54.