Allergy to insulin – a significant clinical problem?
Article Sidebar
Main Article Content
Abstract
Insulin has an important role in the treatment of diabetic patients. The problem of allergy to insulin is not a phenomenon commonly observed. The introduction of new formulations of insulin analogue reduced the incidence of allergic reactions. However, the diagnosis of allergy to insulin in people with type 1 diabetes therapeutic is a real challenge. The paper presents the current state of knowledge about the diagnosis and treatment of allergy to insulin, and presents practical algorithms and differential diagnosis in cases of suspected allergy to insulin.
Downloads
Article Details
Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
2. Cukrzyca. Kompendium. Sieradzki J. (red.). Via Medica, Gdańsk 2009.
3. Wielka Interna. Diabetologia. Moczulski D. (red.). Medical Tribune Polska, Warszawa 2010.
4. Nowe trendy w diabetologii 2012/2013. Czupryniak L. (red.). Termedia, Poznań 2012.
5. Tatoń J., Czech A.: Insulinoterapia cukrzycy oparta na patofizjologii – EBM. Termedia, Poznań 2010.
6. Heinzerling L., Raile K., Rochlitz H. et al.: Insulin allergy: clinical manifestations and management strategies. Allergy 2008, 63: 148-155.
7. Hasselmann C., Pecquet C., Bismuth E. et al.: Continuous subcutaneous insulin infusion allows tolerance induction and diabetes treatment in a type 1 diabetic child with insulin allergy. Diabetes Metab. 2013, 39(2): 174-7.
8. Bliss M.: Chwały wystarczy dla wszystkich. Biblioteka Diabetologii Polskiej. Łódź 2003.
9. Ghazavi M.K., Johnston G.A.: Insulin alergy. Clin. Dermatol. 2011, 29(3): 300-5.
10. [online: http://www.medicines.org.uk/emc/medicine/] .
11. Raap U., Liekenbrocker T., Kapp A. et al.: Delayed-type of hypersensitivity to protamine as a complication of insulin therapy. Contact Dermatitis 2005, 53: 57-58.
12. Goldfine A.B., Kahn C.R.: Insulin allergy and insulin resistance. Curr. Ther. Endocrinol. Metab. 1994, 5: 461-464.
13. Jaeger C., Eckhard M., Brendel M.D. et al.: Diagnostic algorithm and management of immune-mediated complications associated with subcutaneous insulin therapy. Exp. Clin. Endocrinol. Diabetes 2004, 112: 416-421.
14. Jacquier J., Chik C.L., Senior A.: A practical, clinical approach to the assessment and management of suspected insulin allergy. Diabet. Med. 2013, 30: 977-985.
15. Roest M.B., Shaw S., Orron D.I.: Insulin-injection-site reactions associated with type 1 latex allergy. N. Engl. J. Med. 2003, 348: 265-266.
16. Lathela J.T., Knip M., Paul R. et al.: Severe antibody-mediated human insulin resistance: successful treatment with the insulin analog lispro. A case report. Diabetes Care 1997, 20: 71-73.
17. Grammer L.C.: Immunologic reactions to high-molecularweight therapeutic agents. Patterson‘s Allergic Diseases. Baltimore 2009: 304-306.
18. Bodtger U., Wittrup M.: A rational clinical approach to suspected insulin allergy: status after five years and 22 cases. Diabet. Med. 2005, 22(1): 102-6.
19. Mateu V., Franco A., Perez E. et al.: Omalizumab for drug allergy. J. Allergy Clin. Immunol. 2007: 120: 1471-1472.
20. Leonet J., Malaise J., Goffin E. et al.: Solitary pancreas transplantation for life-threatening allergy to human insulin. Transpl. Int. 2006, 19: 474-477.
21. Leonet J., Malaise J., Squifflet J.P.: Refractory insulin allergy: pancreas transplantation or immunosupresive therapy alone? Transpl. Int. 2010, 23: e39-40.