Conjunctival Provocation Test (CPT) – useful tool in diagnostic not only of eye allergic diseases
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Published:
Mar 31, 2008
Keywords:
allergen, conjunctival provocation test
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Abstract
Authors on the ground literature review have tried to sum up knowledge on usefulness of conjunctival provocation test with an allergen. They have shown that it may be useful among other things as: the diagnostic tool, evaluation method of immunotherapy effectiveness, model to investigation of allergic inflammation, the tool to identification of causing factor in different allergic diseases, also professional ones.
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Świebocka , E., Lipiec , A., & Siergiejko , Z. (2008). Conjunctival Provocation Test (CPT) – useful tool in diagnostic not only of eye allergic diseases. Alergoprofil, 4(1), 27-31. Retrieved from https://journalsmededu.pl/index.php/alergoprofil/article/view/46
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
1. Malmberg C.H., Holopainen E.E., Stenius-Aarniala B.S.: Relationship between nasal and conjuncitival test in patients with allergic rhinitis. Clin. Allergy 1978, 8(4): 397-402.
2. Pastorello E.A., Codecasa L.R., Pravettoni V., Qualizza R., Incorvaia C., Ispano M., Stcchi L., Guidoboni A., Zanussi C.: Clinical reliability of diagnostic tests in allergic rhinoconjunctivitis. Boll Ist Sieroter Milan 1988, 67(5 6): 377-385.
3. Mortemousque B., Fauquert J.L., Chiambaretta F., Demoly P., Helleboid L., Creuzot-Garcher C., Bremond-Gignac D.: Conjunctival provocation test: recommendations. J. Fr. Ophtalmol. 2006, 29(7): 837-846.
4. Świebocka E., Siergiejko Z.: Spojówkowy test prowokacyjny z alergenem (CPT) – czy możliwa jest standaryzacja metody? Alergoprofil 2007, 3(4): 7-11.
5. Moller C., Elsayed S.: Seasonal variation of the conjunctival provocation test, and specific IgE in children with birch pollen allergy. Int. Arch. Allergy Appl. Immunol. 1990, 92(3): 306-308.
6. Riechelmann H., Epple B., Groper G.: Comparison of conjunctival and nasal provocation test in allergic rhinitis to house dust mite. Intern. Arch. Allergy Immunol. 2003, 130: 51-59.
7. Leonardi A., Fregona I.A., Gimondi M., Daniotti E., Carniel G., Secchi A.G.: Correlation between conjunctival provocation test (CPT) and systemic allergometric tests in allergic conjunctivitis. Eye 1990, 4 (Pt5): 760-764.
8. Leonardi A., Battista M.C., Gismondi M., Fregona I.A., Secchi A.G.: Antigen sensitivity evaluated by tear-specific and serumspecific IgE, skin test, and conjunctival and nasal provocation test in patients with ocular allergic disease. Eye 1993, 7(Pt 3): 461-464.
9. Akiyama K., Yui Y., Shida T., Miyamoto T.: Relationship between the results of skin, conjunctival and bronchial test and RAST with Candida albicans in patients with asthma. Clin. Allergy 1981, 11(4): 343-351.
10. Stenius-Aarniala B.S.M., Malmberg C.H.O., Holopainen E.E.A.: Relationship between the results of bronchial, nasal and conjuctival provocation tests in patients with asthma. Clin. Exp. Allergy 1978, 8(4): 403-409.
11. Garcia-Ortega P., Costa B., Richart C.: Evaluation of the conjunctival provocation test in allergy diagnosis. Clin. Exp. Allergy 1989, 19(5): 529-532.
12. Garcia Robaina J.C., Sanchez Machin I., Fernandez-Caldas E., Iraola Calvo V., Vazquez Moncholi C., Bonnet Morreno C., de la Torre Morin F.: Skin tests and conjunctival and bronchial challenges with extracts of Blomia tropicalis and Dermatohagoides pteronyssinus in patients with allergic asthma and/or rhinoconjunctivitis. Int. Arch. Allergy Immunol. 2003: 131(3): 182-188.
13. Jutel M., Jaeger L., Suck R., Meyer H., Math D., Fiebig H., Cromwell O.: Allergen-specific immunotherapy with recombinant grass pollen allergens. J. Allergy Clin. Immunol. 2005, 116 (3): 608-613.
14. Valovirta E., Jacobsen L., Ljorring C., Koivikko A., Savolainen J.: Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy 2006, 61(10): 1177-1183.
15. Winther L., Malling H.J., Mosbech H.: Allergen-specific immunotherapy in birch- and grass-pollen allergic rhinitis. II. Side-effects. Allergy 2000, 55(9): 827-835.
16. Niggemann B., Jacobsen L., Dreborg S., Ferdousi H.A., Halken S., Host A., Koivikko A., Koller D., Norberg L.A., Urbanek R., Valovirta E., Wahn U., Möller C., VA PAT Investigator Group: Five-year follow-up on the PAT study: specific immunotherapy and long term prevention of asthma in children. Allergy 2006, 61(7): 855-859.
17. Varney V.A., Gaga M., Frew A.J., Aber V.R., Kay A.B., Durham S.R.: Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. BMJ 1991, 302(6771): 265-269.
18. Tabar A.I., Anda M., Bonifazi F., Bilo M.B., Leynadier F., Fuchs T., Ring J., Galvain S., Andre C.: Specific immunotherapy with standardized latex extract versus placebo in latex – allergic patients. Int. Arch. Allergy Immunol. 2006, 141(4): 369-376.
19. Schulz B.L.: Pharmacology of ocular allergy. Curr. Opin. Allergy Clin. Immunol. 2006, 6(5): 383-389.
20. Friedlaender M.H.: Conjunctival provocation testing: overview of recent clinic trials in ocular allergy. Curr. Opin. Allergy Clin. Immunol. 2002, 2(5): 413-417.
21. Leonardi A.: In vivo diagnostic measurements of ocular inflammation. Curr. Opin. Allergy Clin. Immunol. 2005, 5(5): 464-472.
22. Mita H., Sakuma Y., Shida T., Akiyama K.: Release of chemical mediators in the conjuctival lavage fuids after eye provocation with allergen or compound 48/80. Arerugi 1994, 43(7): 800-808.
23. Bonini S., Bonini S., Vecchione A., Naim D.M., Allansmith M.R., Balsano F.: Inflammmatory changes in conjunctival scrapings after allergen provocation in humans. J. Allergy Clin. Immonol. 1988, 82(3 Pt 1): 141-142.
24. Bonini S., Bonini S., Berruto A., Tomassini M., Carlesimo S., Bucci M.G., Balsano F.: Conjunctival provocation test as a model for the study of allergy and inflammation in humans. Int. Arch. Allergy Appl. Immunol. 1989, 88(1-2): 144-148.
25. Bonini S., Schiavone M., Bonini S., Magrini L., Lischetti P., Lambiase A., Bucci M.G.: Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis. Ophthalmology 1997, 104(5): 849-853.
26. Lanier B.Q., Abelson M.B., Berger W.E., Granet D.B., D’Arienzo P.A., Spangler D.L., Kägi M.K.: Comparison of the efficacy of combined fluticasone propionate and olopatadine versus combined fluticasone propionate and fexofenadine for the treatment of allergic rhinoconjunctivitis induced by conjunctival allergen challenge. Clin. Ther. 2002, 24(7): 1161-1174.
27. Crampton H.J.: Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial. Clin. Ther. 2003, 25(7): 1975-1987.
28. Leonardi A., Abelson M.B.: Double-masked, randomized, placebo-controlled clinical study of the mast cell-stabilizing effects of treatment with olopatadine in the conjunctival allergen challenge model in humans. Clin. Ther. 2003, 25(10): 2539-2552.
29. Laukkanen A., Ruoppi P., Makinen-Kiljunen S.: Deer ked-induced occupational allergic rhinoconcjunctivitis. Ann. Allergy Asthma Immunol. 2005, 94(5): 604-608.
30. Carballada F., Sanchez R., Carballas C., Lombardero M., Boquete M.: Occupational respiratory allergy to roe deer. Ann. Allergy Asthma Immunol. 2006, 97(5): 707-710.
31. Brito F., Mur P., Bartolome B., Gomez E., Galindo P.A., Borja J., Alonso A.: Rhinoconjunctivitis and asthma caused by corn plant (Dracena fragans). Ann. Allergy Asthma Immunol. 2007, 98(3): 290-293.
32. Brito F., Martinez A., Palascios R.: Rhinoconjunctivitis and asthma caused by vine pollen: A case report. J. Allergy Clin. Immunol. 1999, 103: 262-266.
33. Kibby T., Akl M.: Prevalence of latex sensitization in a hospital employee population. Ann. Allergy Asthma Immunol. 1997, 78: 41-44.
34. Garcia-Medina J.J., Garcia-Medina M., Zanon-Moreno V.C., Scalerandi G., Pinazo-Duran M.D.: Concjunctival provocation test for the diagnosis of ocular hypersensivity to chlorambutanol. Cornea 2007, 26(1): 94-97.
35. El-Qutob Lopez D., Morales Rubio C., Cervera Aznar R., Pelaez Hernandez A.: Allergic reaction after ingestion or orange blossom pollen. J. Investig. Allergol. Clin. Immunol. 2006, 16(2): 140-141.
36. Lluch-Bernal M., Sastre J., Fernandez-Caldas E., Maranon F., Cuesta-Herranz J., de las Heras M., Quirce S., Novablos A.: Conjunctival provocation tests in the diagnosis of Anisakis simplex hypersensitivity. J. Investig. Allergol. Clin. Immunol. 2002, 12(1): 21-24.
37. Rutkowski R., Rutkowski K., Moniuszko T., Tarasiuk W.: Allergic anisakiasis. Polish J. Environ. Stud. 2006, 16(1A): 63-67.
2. Pastorello E.A., Codecasa L.R., Pravettoni V., Qualizza R., Incorvaia C., Ispano M., Stcchi L., Guidoboni A., Zanussi C.: Clinical reliability of diagnostic tests in allergic rhinoconjunctivitis. Boll Ist Sieroter Milan 1988, 67(5 6): 377-385.
3. Mortemousque B., Fauquert J.L., Chiambaretta F., Demoly P., Helleboid L., Creuzot-Garcher C., Bremond-Gignac D.: Conjunctival provocation test: recommendations. J. Fr. Ophtalmol. 2006, 29(7): 837-846.
4. Świebocka E., Siergiejko Z.: Spojówkowy test prowokacyjny z alergenem (CPT) – czy możliwa jest standaryzacja metody? Alergoprofil 2007, 3(4): 7-11.
5. Moller C., Elsayed S.: Seasonal variation of the conjunctival provocation test, and specific IgE in children with birch pollen allergy. Int. Arch. Allergy Appl. Immunol. 1990, 92(3): 306-308.
6. Riechelmann H., Epple B., Groper G.: Comparison of conjunctival and nasal provocation test in allergic rhinitis to house dust mite. Intern. Arch. Allergy Immunol. 2003, 130: 51-59.
7. Leonardi A., Fregona I.A., Gimondi M., Daniotti E., Carniel G., Secchi A.G.: Correlation between conjunctival provocation test (CPT) and systemic allergometric tests in allergic conjunctivitis. Eye 1990, 4 (Pt5): 760-764.
8. Leonardi A., Battista M.C., Gismondi M., Fregona I.A., Secchi A.G.: Antigen sensitivity evaluated by tear-specific and serumspecific IgE, skin test, and conjunctival and nasal provocation test in patients with ocular allergic disease. Eye 1993, 7(Pt 3): 461-464.
9. Akiyama K., Yui Y., Shida T., Miyamoto T.: Relationship between the results of skin, conjunctival and bronchial test and RAST with Candida albicans in patients with asthma. Clin. Allergy 1981, 11(4): 343-351.
10. Stenius-Aarniala B.S.M., Malmberg C.H.O., Holopainen E.E.A.: Relationship between the results of bronchial, nasal and conjuctival provocation tests in patients with asthma. Clin. Exp. Allergy 1978, 8(4): 403-409.
11. Garcia-Ortega P., Costa B., Richart C.: Evaluation of the conjunctival provocation test in allergy diagnosis. Clin. Exp. Allergy 1989, 19(5): 529-532.
12. Garcia Robaina J.C., Sanchez Machin I., Fernandez-Caldas E., Iraola Calvo V., Vazquez Moncholi C., Bonnet Morreno C., de la Torre Morin F.: Skin tests and conjunctival and bronchial challenges with extracts of Blomia tropicalis and Dermatohagoides pteronyssinus in patients with allergic asthma and/or rhinoconjunctivitis. Int. Arch. Allergy Immunol. 2003: 131(3): 182-188.
13. Jutel M., Jaeger L., Suck R., Meyer H., Math D., Fiebig H., Cromwell O.: Allergen-specific immunotherapy with recombinant grass pollen allergens. J. Allergy Clin. Immunol. 2005, 116 (3): 608-613.
14. Valovirta E., Jacobsen L., Ljorring C., Koivikko A., Savolainen J.: Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy 2006, 61(10): 1177-1183.
15. Winther L., Malling H.J., Mosbech H.: Allergen-specific immunotherapy in birch- and grass-pollen allergic rhinitis. II. Side-effects. Allergy 2000, 55(9): 827-835.
16. Niggemann B., Jacobsen L., Dreborg S., Ferdousi H.A., Halken S., Host A., Koivikko A., Koller D., Norberg L.A., Urbanek R., Valovirta E., Wahn U., Möller C., VA PAT Investigator Group: Five-year follow-up on the PAT study: specific immunotherapy and long term prevention of asthma in children. Allergy 2006, 61(7): 855-859.
17. Varney V.A., Gaga M., Frew A.J., Aber V.R., Kay A.B., Durham S.R.: Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. BMJ 1991, 302(6771): 265-269.
18. Tabar A.I., Anda M., Bonifazi F., Bilo M.B., Leynadier F., Fuchs T., Ring J., Galvain S., Andre C.: Specific immunotherapy with standardized latex extract versus placebo in latex – allergic patients. Int. Arch. Allergy Immunol. 2006, 141(4): 369-376.
19. Schulz B.L.: Pharmacology of ocular allergy. Curr. Opin. Allergy Clin. Immunol. 2006, 6(5): 383-389.
20. Friedlaender M.H.: Conjunctival provocation testing: overview of recent clinic trials in ocular allergy. Curr. Opin. Allergy Clin. Immunol. 2002, 2(5): 413-417.
21. Leonardi A.: In vivo diagnostic measurements of ocular inflammation. Curr. Opin. Allergy Clin. Immunol. 2005, 5(5): 464-472.
22. Mita H., Sakuma Y., Shida T., Akiyama K.: Release of chemical mediators in the conjuctival lavage fuids after eye provocation with allergen or compound 48/80. Arerugi 1994, 43(7): 800-808.
23. Bonini S., Bonini S., Vecchione A., Naim D.M., Allansmith M.R., Balsano F.: Inflammmatory changes in conjunctival scrapings after allergen provocation in humans. J. Allergy Clin. Immonol. 1988, 82(3 Pt 1): 141-142.
24. Bonini S., Bonini S., Berruto A., Tomassini M., Carlesimo S., Bucci M.G., Balsano F.: Conjunctival provocation test as a model for the study of allergy and inflammation in humans. Int. Arch. Allergy Appl. Immunol. 1989, 88(1-2): 144-148.
25. Bonini S., Schiavone M., Bonini S., Magrini L., Lischetti P., Lambiase A., Bucci M.G.: Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis. Ophthalmology 1997, 104(5): 849-853.
26. Lanier B.Q., Abelson M.B., Berger W.E., Granet D.B., D’Arienzo P.A., Spangler D.L., Kägi M.K.: Comparison of the efficacy of combined fluticasone propionate and olopatadine versus combined fluticasone propionate and fexofenadine for the treatment of allergic rhinoconjunctivitis induced by conjunctival allergen challenge. Clin. Ther. 2002, 24(7): 1161-1174.
27. Crampton H.J.: Comparison of ketotifen fumarate ophthalmic solution alone, desloratadine alone, and their combination for inhibition of the signs and symptoms of seasonal allergic rhinoconjunctivitis in the conjunctival allergen challenge model: a double-masked, placebo- and active-controlled trial. Clin. Ther. 2003, 25(7): 1975-1987.
28. Leonardi A., Abelson M.B.: Double-masked, randomized, placebo-controlled clinical study of the mast cell-stabilizing effects of treatment with olopatadine in the conjunctival allergen challenge model in humans. Clin. Ther. 2003, 25(10): 2539-2552.
29. Laukkanen A., Ruoppi P., Makinen-Kiljunen S.: Deer ked-induced occupational allergic rhinoconcjunctivitis. Ann. Allergy Asthma Immunol. 2005, 94(5): 604-608.
30. Carballada F., Sanchez R., Carballas C., Lombardero M., Boquete M.: Occupational respiratory allergy to roe deer. Ann. Allergy Asthma Immunol. 2006, 97(5): 707-710.
31. Brito F., Mur P., Bartolome B., Gomez E., Galindo P.A., Borja J., Alonso A.: Rhinoconjunctivitis and asthma caused by corn plant (Dracena fragans). Ann. Allergy Asthma Immunol. 2007, 98(3): 290-293.
32. Brito F., Martinez A., Palascios R.: Rhinoconjunctivitis and asthma caused by vine pollen: A case report. J. Allergy Clin. Immunol. 1999, 103: 262-266.
33. Kibby T., Akl M.: Prevalence of latex sensitization in a hospital employee population. Ann. Allergy Asthma Immunol. 1997, 78: 41-44.
34. Garcia-Medina J.J., Garcia-Medina M., Zanon-Moreno V.C., Scalerandi G., Pinazo-Duran M.D.: Concjunctival provocation test for the diagnosis of ocular hypersensivity to chlorambutanol. Cornea 2007, 26(1): 94-97.
35. El-Qutob Lopez D., Morales Rubio C., Cervera Aznar R., Pelaez Hernandez A.: Allergic reaction after ingestion or orange blossom pollen. J. Investig. Allergol. Clin. Immunol. 2006, 16(2): 140-141.
36. Lluch-Bernal M., Sastre J., Fernandez-Caldas E., Maranon F., Cuesta-Herranz J., de las Heras M., Quirce S., Novablos A.: Conjunctival provocation tests in the diagnosis of Anisakis simplex hypersensitivity. J. Investig. Allergol. Clin. Immunol. 2002, 12(1): 21-24.
37. Rutkowski R., Rutkowski K., Moniuszko T., Tarasiuk W.: Allergic anisakiasis. Polish J. Environ. Stud. 2006, 16(1A): 63-67.