Ebastine in the treatment of allergic diseases Review article
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Abstract
Allergic diseases are among the most common chronic diseases in children, adolescents and young adults. The key mediator released in the acute phase of an allergic reaction is histamine. Histamine induces the typical symptoms of allergic rhinitis (nasal itching, sneezing), conjunctivitis (itching, burning, sand under the eyelids) and urticaria (wheal, erythema, itching of the skin). The main symptomatic drugs used in the management of allergic diseases include antihistamines – H1 receptor blockers. Ebastine belongs to the modern, highly selective, second-generation antihistamines. Registered in the doses of 10 mg and 20 mg in the treatment of allergic rhinitis and conjunctivitis in children from 12 years of age and adults, and in the dose of 10 mg in the treatment of urticaria in adults. Ebastine has been shown to be highly effective in reducing the severity of the symptoms of seasonal and perennial allergic rhinitis in a number of clinical trials, including a clear effect of the drug on nasal blockage. Likewise, ebastine showed good efficacy and an optimal safety profile in the treatment of urticaria. Ebastine has been found to have a favourable risk to benefit ratio with regard to sedation and has no clinically significant adverse effect on cognition or psychomotor performance. Ebastine represents a valuable tool in the pharmacotherapy of allergic diseases in our daily clinical practice.
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