The clinical significance of nitric oxide concentration in air exhaled through the nose in patients with seasonal allergic rhinitis
Article Sidebar
Main Article Content
Abstract
Abstract: Introduction: The consequence of still increasing phenomenon of atopic diseases is seasonal allergic rhinitis (SAR). Nasal nitric oxide measurement seems to be a useful method in diagnosis and monitoring of SAR.
Aim: The aim of the study was the evaluation of nitric oxide concentration (NO) in air exhaled through the nose in patients with seasonal allergic rhinitis in correlation with the assessment of life quality (questionnaire RQLQ – Rhiniconjuctivitis Quality of Life Questionnaire) in these patients.
Materials and methods: The study was conducted in 60 people divided into two groups. The test group consisted of 30 SAR patients with grass pollen allergy. The control group consisted of 30 healthy volunteers without allergic rhinitis, asthma or sinusitis. The measurement of exhaled NO was performed by specialized medical equipment – Medisoft Hypair 230. The assessment of quality of life was performed using the RQLQ questionnaire.
Results: Patients with SAR achieved relatively higher average measurement of the concentration of nitric oxide (1537.5) than the healthy participants (559.17). The results in each category performed questionnaire were also higher in test group than in the controls. This also applies to the overall result of the survey, which was significantly higher in subjects with SAR. There was no correlation (r < 0.2; p = 0.05) when compared nNO measurement results with the results obtained from the individual categories of the survey and its outcome overall.
Conclusions: 1. The concentration of nitric oxide in air exhaled through the nose was significantly higher in patients with seasonal allergic rhinitis during the pollen season than in healthy individuals. However, it did not correlate with the life quality in these patients. 2. Determination of nasal fraction of nitrogen oxide is a useful, non-invasive diagnostic method for evaluation of inflammation activity in seasonal allergic rhinitis.
Downloads
Article Details
Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
2. Świerczyńska-Machura D., Krakowiak A., Wiszniewska M. et al.: Diagnostyka astmy zawodowej: monitorowanie stężenia tlenku azotu w powietrzu wydechowym. Med. Pr. 2005, 56(6): 485-490.
3. Kłak A., Krzych-Fałta E., Samoliński B.: Rola tlenku azotu w stanie zapalnym dróg oddechowych. Alerg. Astma Immun. 2013, 18(2): 91-96.
4. Ziętkowski Z., Ziętkowska E., Bodzenta-Łukaszyk A.: Kliniczne znaczenie pomiarów tlenku azotu w powietrzu wydychanym w chorobach układu oddechowego. Alerg. Astma Immun. 2009, 14(4): 215-222.
5. Ziora D., Misiołek M.: Pomiar stężenia tlenku azotu w diagnostyce chorób dróg oddechowych. W: Krzeski A. (red.): Diagnostyka rynologiczna. Medycyna Praktyczna, Kraków 2009, 121-124.
6. Alving K., Weitzberg E., Lundberg J.M.: Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J. 1993, 6: 1368-1370.
7. Wodehouse T., Kharitonov S.A., Mackay I.S. et al.: Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur. Respir. J. 2003, 21: 43-47.
8. Dotsch J., Demirakca S., Terbrack H.G. et al.: Airway nitric oxide in asthmatic children and patients with cystic fibrosis. Eur. Respir. J. 1996, 9: 2537-2540.
9. Lundberg J.O., Nordvall S.L., Weitzberg E. et al.: Exhaled nitric oxide in paediatric asthma and fibrosis. Arch. Dis. Child 1996, 75: 323-326.
10. Olin A.C., Andersson M., Granung G.: Atopic subjects without respiratory symptoms have normal exhaled NO. Am. J. Respir. Crit. Care Med. 2001, 163: 46.
11. Gratziou C., Lignos M., Dassiou M.: Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Eur. Respir. J. 1999, 14: 897-901.
12. Henriksen A.H., Sue-Chu M., Lingaas H.T.: Exhales and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness. Eur. Respir. J. 1999, 13: 301-306.
13. Alexanderson C., Olin A., Dahlman-Hoglund A. et al.: Nasal nitric oxide in a random sample of adults and its relationship to sensitization, cat allergen, rhinitis and ambient nitric oxide. Am. J. Rhinol. Allergy 2012, 26(3): e99-e103.
14. Struben V.M.D., Wieringa M.H., Feenstra L. et al.: Nasal nitric oxide and nasal allergy. Allergy 2006, 61: 665-670.
15. Roberts G., Mylonopoulou M., Hurley C. et al.: Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clin. Exp. Allergy 2005, 35: 1295-1300.
16. Tworek D., Bocheńska-Marciniak M., Kupczyk M. et al.: Brak korelacji między stężeniem tlenku azotu w powietrzu wydychanym (eNO) a klinicznymi wskaźnikami nasilenia choroby i jakością życia w grupie chorych na lekką i umiarkowaną astmę oskrzelową. Pneumonol. Alergol. Pol. 2006, 74: 391-395.
17. Rapiejko P., Dżaman K., Modrzyński M. et al.: Badanie jakości życia pacjentów z alergicznym nieżytem nosa. Ann. Univ. Mariae Curie Sklodowska 2005, 60(16): 451-455.