Vitamin D3 in SARS-CoV-2 infection Review article
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Published:
May 27, 2020
Keywords:
COVID-19, SARS-CoV-2, vitamin D3, supplementation
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Abstract
COVID-19 pandemic and vitamin D3 deficiency are connected. Both are responsible for civilization diseases. Thanks to its immunotherapeutic and anti-inflammatory properties vitamin D3 could be taken into consideration for prophylaxis and treatment of coronavirus infection.
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Samoliński , B., Krzych-Fałta , E., Wojas , O., & Samoliński , K. (2020). Vitamin D3 in SARS-CoV-2 infection. Alergoprofil, 16(2), 16-20. https://doi.org/10.24292/01.AP.162270520
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THERAPY
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
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6. Dickie LJ, Church LD, Coulthard LR et al. Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology. 2010; 49: 1466-71.
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8. Gorman S, Judge MA, Hart PH. Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells. Immunology. 2010; 131: 415-25.
9. Shalita-Chesner M, Koren R, Mekori YA et al. 1,25-Dihydroxyvitamin D3 enhances degranulation of mast cells. Mol Cell Endocrinol. 1998; 142: 49-55.
10. Gorman S, Tan DH, Lambert MJ et al. Vitamin D3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease. Pediatr Allergy Immunol. 2012; 23: 83-7.
11. Hansdottir S, Monick MM, Lovan N et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappa B-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010; 184: 965-74.
12. Białek-Gosk K. Wpływ witaminy D na przebieg chorób układu oddechowego. Terapia. 2015; reprint: 8-14.
13. Majak P, Kuna P. Rola witaminy D3 w leczeniu astmy w świetle najnowszych danych. Terapia. 2015; reprint: 15-17.
14. Cebey-López M, Pardo-Seco J, Gómez-Carballa A et al. GENDRES network Vitamin D Role in Hospitalized Children with Lower Tract Acute Respiratory Infections. J Pediatr Gastroenterol Nutr. 2015; 9.
15. Ponnarmeni S, Kumar Angurana S, Singhi S et al. Vitamin D deficiency in critically ill children with sepsis. Paediatr Int Child Health. 2016; 36(1): 15-21. http://doi/10.1179/2046905515Y0000000042.
16. Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiology. 2015; 15: 84.
17. Martineau AR, Hanifa Y, Witt KD et al. Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax. 2015; 70(10): 953-60.
18. Monlezun DJ, Bittner EA, Kenneth B et al. Vitamin D Status and Acute Respiratory Infection: Cross Sectional Results from the United States National Health and Nutrition Examination Survey, 2001-2006. Nutrients. 2015; 7: 1933-44.
19. Ayesha NK, Karim SL, Amber UL et al. Association of Vitamin D Status and Acute Rhinosinusitis, Results from the United States National Health and Nutrition Examination Survey 2001-2006. Medicine. 94(40): e1447.
20. Bergman P, Norlin AC, Hansen S et al. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo controlled trial BMC Res Notes 2015; 8: 391. http://doi.org/10.1186/s13104-015-1378-3.
21. Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect. 2007; 135: 1095-6.
22. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010; 91: 1255-60.
23. Hoffmann M, Kleine-Weber H, Schroeder S et al. SARSCoV- 2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-80. http://doi.org/10.1016/j.cell.2020.02.052.
24. Conti P, Ronconi G, Caraffa A et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020; 34(2): 1. http://doi.org/10.23812/CONTI-E .
25. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. 2011; 86: 217-37.
26. Xu J, Yang J, Chen J et al. Vitamin D alleviates lipopolysaccharide- induced acute lung injury via regulation of the renin- angiotensin system. Mol Med Rep. 2017; 16: 7432-8.
27. Rehan VK, Torday JS, Peleg S et al. 1Alpha,25-dihydroxy- 3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Mol Genet Metab. 2002; 76: 46-56.
28. Han JE, Jones JL, Tangpricha V et al. High-dose vitamin D administration in ventilated intensive care unit patients: a pilot double blind randomized controlled trial. J Clin Transl Endocrinol. 2016; 4: 59-65.
29. Smith EM, Jones JL, Han JE et al. High-dose vitamin D3 administration is associated with increases in hemoglobin concentrations in mechanically ventilated critically Ill adults: a pilot double-blind, randomized, placebo-controlled trial. JPEN J Parenter Enter Nutr. 2018; 42: 87-94.
30. Rusińska A, Płudowski P, Walczak M et al. Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland – Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies – 2018 Update. Front Endocrinol. 2018; 9:246. http://doi.org/10.3389/fendo.2018.00246.
31. Grant BW, Lahore H, McDonnell S et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020; 12: 988. http://doi.org/10.3390/nu12040988.
2. Hidalgo AA, Trump DL, Johnson CS. Glucocorticoid regulation of the vitamin D receptor. J Steroid Biochem Mol Biol. 2010; 121(1-2): 372-5.
3. Nagalski A, Kiersztan A. Fizjologia i molekularny mechanizm działania glikokortrykoidów. Post Hig Med Dośw. 2010; 64: 133-45.
4. Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol. 2011; 347: 97-105.
5. Chishimba L, Thickett DR, Stockley RA et al. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax. 2010; 65: 456-62.
6. Dickie LJ, Church LD, Coulthard LR et al. Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology. 2010; 49: 1466-71.
7. Matheu V, Back O, Mondoc E et al. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol. 2003; 112: 585-92.
8. Gorman S, Judge MA, Hart PH. Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells. Immunology. 2010; 131: 415-25.
9. Shalita-Chesner M, Koren R, Mekori YA et al. 1,25-Dihydroxyvitamin D3 enhances degranulation of mast cells. Mol Cell Endocrinol. 1998; 142: 49-55.
10. Gorman S, Tan DH, Lambert MJ et al. Vitamin D3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease. Pediatr Allergy Immunol. 2012; 23: 83-7.
11. Hansdottir S, Monick MM, Lovan N et al. Vitamin D decreases respiratory syncytial virus induction of NF-kappa B-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol. 2010; 184: 965-74.
12. Białek-Gosk K. Wpływ witaminy D na przebieg chorób układu oddechowego. Terapia. 2015; reprint: 8-14.
13. Majak P, Kuna P. Rola witaminy D3 w leczeniu astmy w świetle najnowszych danych. Terapia. 2015; reprint: 15-17.
14. Cebey-López M, Pardo-Seco J, Gómez-Carballa A et al. GENDRES network Vitamin D Role in Hospitalized Children with Lower Tract Acute Respiratory Infections. J Pediatr Gastroenterol Nutr. 2015; 9.
15. Ponnarmeni S, Kumar Angurana S, Singhi S et al. Vitamin D deficiency in critically ill children with sepsis. Paediatr Int Child Health. 2016; 36(1): 15-21. http://doi/10.1179/2046905515Y0000000042.
16. Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiology. 2015; 15: 84.
17. Martineau AR, Hanifa Y, Witt KD et al. Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax. 2015; 70(10): 953-60.
18. Monlezun DJ, Bittner EA, Kenneth B et al. Vitamin D Status and Acute Respiratory Infection: Cross Sectional Results from the United States National Health and Nutrition Examination Survey, 2001-2006. Nutrients. 2015; 7: 1933-44.
19. Ayesha NK, Karim SL, Amber UL et al. Association of Vitamin D Status and Acute Rhinosinusitis, Results from the United States National Health and Nutrition Examination Survey 2001-2006. Medicine. 94(40): e1447.
20. Bergman P, Norlin AC, Hansen S et al. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo controlled trial BMC Res Notes 2015; 8: 391. http://doi.org/10.1186/s13104-015-1378-3.
21. Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect. 2007; 135: 1095-6.
22. Urashima M, Segawa T, Okazaki M et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010; 91: 1255-60.
23. Hoffmann M, Kleine-Weber H, Schroeder S et al. SARSCoV- 2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-80. http://doi.org/10.1016/j.cell.2020.02.052.
24. Conti P, Ronconi G, Caraffa A et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020; 34(2): 1. http://doi.org/10.23812/CONTI-E .
25. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. 2011; 86: 217-37.
26. Xu J, Yang J, Chen J et al. Vitamin D alleviates lipopolysaccharide- induced acute lung injury via regulation of the renin- angiotensin system. Mol Med Rep. 2017; 16: 7432-8.
27. Rehan VK, Torday JS, Peleg S et al. 1Alpha,25-dihydroxy- 3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Mol Genet Metab. 2002; 76: 46-56.
28. Han JE, Jones JL, Tangpricha V et al. High-dose vitamin D administration in ventilated intensive care unit patients: a pilot double blind randomized controlled trial. J Clin Transl Endocrinol. 2016; 4: 59-65.
29. Smith EM, Jones JL, Han JE et al. High-dose vitamin D3 administration is associated with increases in hemoglobin concentrations in mechanically ventilated critically Ill adults: a pilot double-blind, randomized, placebo-controlled trial. JPEN J Parenter Enter Nutr. 2018; 42: 87-94.
30. Rusińska A, Płudowski P, Walczak M et al. Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland – Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies – 2018 Update. Front Endocrinol. 2018; 9:246. http://doi.org/10.3389/fendo.2018.00246.
31. Grant BW, Lahore H, McDonnell S et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020; 12: 988. http://doi.org/10.3390/nu12040988.