Ifosfamide-induced encephalopathy in a patient with metastatic fibrosarcoma Case report

Main Article Content

Łukasz Galus

Abstract

Ifosfamide is a cytostatic drug commonly used in chemotherapy. One of the common adverse effects resulting from the treatment with ifosfamide is encephalopathy. This paper describes a case study of a 64-year-old patient who suffered from a full-blown encephalopathy as a result of chemotherapy administered during the treatment of fibrosarcoma of the femur. It provides a hypothesis of the mechanism behind toxic effects of ifosfamide on the central nervous system and elaborates on a number of documented ways of preventing aforementioned complications.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Article Details

How to Cite
1.
Galus Łukasz. Ifosfamide-induced encephalopathy in a patient with metastatic fibrosarcoma. OncoReview [Internet]. 2016Oct.3 [cited 2024Apr.30];6(4(24):179-83. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/497
Section
Articles

References

1. Lohr L. Ifosfamide neurotoxicity and potential treatment with methylene blue. HemOnc Today 2008; 9(7): 15.
2. Pelgrims J, De Vos F, Van den Brande J et al. Methyline blue in the treatment and prevention of ifosfamide induced encephalopathy: raport of 12 cases and review of literature. Br J Cancer 2000; 82(2): 291-294.
3. Curtin JP, Koonings PP, Gutierrez M et al. Ifosfamide-induced neurotoxicity. Gynecol Oncol 1991; 42(3): 192-193.
4. DiMaggio JR, Brown R, Baile WF et al. Hallucinations and ifosfamide-induced neurotoxicity. Cancer 1994; 73(5): 1509-1514.
5. Küpfer A, Aeschlimann C, Cerny T. Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy. Eur J Clin Pharmacol 1996; 50(4): 249-252.
6. Kurowski V, Cerny T, Küpfer A et al. Metabolism and pharmacokinetics of oral and intravenous ifosfamide. J Cancer Res Clin Oncol 1991; 117(supl. 4): S148-S153.
7. Aeschlimann C, Küpfer A, Schefer H et al. Comparative pharmacokinetics of oral and intravenous ifosfamide/mesna/methylene blue therapy. Drug Metab Dispos 1998; 26(9): 883-890.
8. Malhotra A, Poiesz BJ, Burgdorf AW et al. Ifosfamide Induced Neurotoxicity Secondary to Concomitant Aprepitant Use. Adv Pharmacoepidem Drug Safety 2012; 1: 3 http://dpi.org/10.4172/2167-1052.1000114.
9. Kaijser GP, Beijnen JH, Bult A et al. Ifosfamide metabolism and pharmacokinetics (review). Anticancer Res 1994; 14: 517-531.
10. Sweiss K, Beri R, Shord SS. Encephalopathy after high-dose Ifosfamide: a retrospective cohort study and review of the literature. Drug Saf 2008; 31(11): 989-996.
11. Lo Y, Shen LJ, Chen WH et al. Risk factors of ifosfamide-related encephalopathy in adult patient with cancer: A retrospective analysis. J Formos Med Assoc 2015; 115(9): 744-751. http://dx.doi.org/10.1016/j.jfma.2015.07.016.
12. Szabatura A, Cirrone F, Harris C et al. An assessment of risk factors associated with ifosfamide-induced encephalopathy in large academic cancer center. J Oncol Pharm Pract 2015; 21(3): 188-193.
13. Küpfer A, Aeschlimann C, Wermuth B et al. Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue. Lancet 1994; 343(8900): 763-764.
14. Koschuth A, Spath-Schwalbe E, Possinger K. Methylenblau bei Ifosfamid-induzirerter Enzephalopathie. Dtsch Med Wochenschr 1996; 121: 1210.
15. Imtiaz S, Muzaffar N. Ifosfamide neurotoxicty in young female with remarkable response to Thiamine. J Pak Med Assoc 2010; 60(10): 867-869.
16. Buesa JM, Garcia-Teijido P, Losa R et al. Treatment of ifosfamide encephalopathy with intravenous thiamin. Clin Cancer Res 2003; 9(12): 4636-4637.