The cardiac safety during treatment with sunitinib and sorafenib, multikinase angiogenesis inhibitors Review article
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Published:
Jun 29, 2012
Keywords:
angiogenesis inhibitors, cardiotoxcity, heart failure, arterial and venous thromboembolic events
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Abstract
Cardiotoxicity of multikinase angiogenesis inhibitors, sunitinib and sorafenib, is most often myocardial systolic dysfunction or arterial and venous thromboembolic events. Essential risk factor seems to be iatrogenic arterial hypertension, which is a typical (“class effect”) vascular complication and a predictive factor of the anticancer efficiency. A biochemical and molecular aspect is associated with cardiomyocytes damage and endothelial dysfunction. Specific primary cardioprotective options are still unknown. It was shown the real risk of cardiotoxicity of multikinase angiogenesis inhibitors, sunitinib and sorafenib, in relation to the risk of cardiotoxicity of bevacizumab, the monoclonal antibody anti-VEGF.
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Szmit S. The cardiac safety during treatment with sunitinib and sorafenib, multikinase angiogenesis inhibitors. OncoReview [Internet]. 2012Jun.29 [cited 2024Nov.23];2(2(6):134-42. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/307
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
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4. Yancik R., Wesley M.N., Ries L.A. et al.: Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA 2001; 285: 885-892.
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6. Mulrooney D.A., Yeazel M.W., Kawashima T. et al.: Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009; b4606: 339.
7. Yeh E.T., Bickford C.L.: Cardiovascular complications of cancer therapy: incidence, pathogenesis,diagnosis, and management. J. Am. Coll. Cardiol. 2009; 53: 2231-2247.
8. Maitland M.L., Bakris G.L., Black H.R. et al.: Cardiovascular Toxicities Panel, Convened by the Angiogenesis Task Force of the National Cancer Institute Investigational Drug Steering Committee. Initial Assessment, Surveillance, and Management of Blood Pressure in Patients Receiving Vascular Endothelial Growth Factor Signaling Pathway Inhibitors. J. Natl. Cancer Inst. 2010; 102: 596-604.
9. Chu T.F., Rupnick M.A., Kerkela R., Dallabrida S.M., Zurakowski D., Nguyen L. et al.: Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007; 370: 2011-2019.
10. Will Y., Dykens J.A., Nadanaciva S., Hirakawa B., Jamieson J., Marroquin L.D. et al.: Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells. Toxicol. Sci. 2008; 106: 153-161.
11. Gupta R., Maitland M.L.: Sunitinib, hypertension, and heart failure: a model for kinase inhibitor-mediated cardiotoxicity. Curr. Hypertens. Rep. 2011; 13(6): 430-5.
12. Launay-Vacher V., Deray G.: Hypertension and proteinuria: a class-effect of antiangiogenic therapies. Anticancer Drugs 2009 Jan; 20(1): 81-2.
13. Sica D.A.: Angiogenesis inhibitors and hypertension: an emerging issue. J. Clin. Oncol. 2006; 24: 1329-31.
14. Rini B.I., Cohen D.P., Lu D.R., Chen I., Hariharan S., Gore M.E., Figlin R.A., Baum M.S., Motzer R.J.: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J. Natl. Cancer Inst. 2011 May 4; 103(9): 763-73.
15. Jain L., Sissung T.M., Danesi R. et al.: Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib. J. Exp. Clin. Cancer Res. 2010 Jul 14; 29: 95.
16. Ravaud A., Sire M.: Arterial hypertension and clinical benefit of sunitinib, sorafenib and bevacizumab in first and second-line treatment of metastatic renal cell cancer. Ann. Oncol. 2009; 20(5): 966-7.
17. Szmit S., Langiewicz P., Zołnierek J., Nurzyński P., Zaborowska M., Filipiak K.J., Opolski G., Szczylik C.: Hypertension as a predictive factor for survival outcomes in patients with metastatic renal cell carcinoma treated with sunitinib after progression on cytokines. Kidney Blood Press. Res. 2012; 35(1): 18-25.
18. Rutkowski P., Bylina E., Switaj T. et al.: An analysis of arterial hypertension and mutational status as predictive factors for results of sunitinib (SU) therapy in gastrointestinal stromal tumors (GIST). ASCO Meeting Abstracts 2011; 29(15 Suppl): 10017.
19. Szmit S., Zaborowska M., Waśko-Grabowska A., Zołnierek J., Nurzyński P., Filipiak K.J., Opolski G., Szczylik C.: Cardiovascular Comorbidities for Prediction of Progression-Free Survival in Patients with Metastatic Renal Cell Carcinoma Treated with Sorafenib. Kidney Blood Press. Res. 2012 Jun 6; 35(6): 468-476.
20. Force T., Krause D.S., Van Etten R.A.: Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat. Rev. Cancer 2007; 7: 332-344.
21. Izumiya Y., Shiojima I., Sato K., Sawyer D.B., Colucci W.S., Walsh K.: Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension 2006; 47: 887-893.
22. Kamba T., Tam B.Y., Hashizume H., Haskell A., Sennino B., Mancuso M.R. et al.: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am. J. Physiol. Heart Circ. Physiol. 2006; 290: H560-H576.
23. Chintalgattu V., Ai D., Langley R.R. et al.: Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to loadinduced stress. J. Clin. Invest. 2010; 120: 472-484.
24. Kerkela R., Woulfe K.C., Durand J.B. et al.: Sunitinib-induced cardiotoxicity is mediated by offtarget inhibition of AMP-activated protein kinase. Clin. Transl. Sci. 2009; 2: 15-25.
25. Kappers M.H., van Esch J.H., Sleijfer S., Danser A.H., van den Meiracker A.H.: Cardiovascular and renal toxicity during angiogenesis inhibition: clinical and mechanistic aspects. J. Hypertens. 2009 Dec; 27(12): 2297-309.
26. Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Rixe O. et al.: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 2007; 356: 115-124.
27. Motzer R.J., Michaelson M.D., Redman B.G., Hudes G.R., Wilding G., Figlin R.A. et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2006; 24: 16-24.
28. Demetri G.D., van Oosterom A.T., Garrett C.R., Blackstein M.E., Shah M.H., Verweij J. et al.: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomized controlled trial. Lancet 2006; 368: 1329-1338.
29. Khakoo A.Y., Kassiotis C.M., Tannir N., Plana J.C., Halushka M., Bickford C. et al.: Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer 2008; 112: 2500-2508.
30. Schmidinger M., Zielinski C.C., Vogl U.M., Bojic A., Bojic M., Schukro C. et al.: Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2008; 26: 5204-5212.
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