The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies Review article

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Published: Jul 18, 2023
DOI: https://doi.org/10.24292/01.OR.132170723
Keywords:
E2F2, E2F, cancer, transcription factor, oncology, p53, p21

Main Article Content

Julia Domańska
National Medical Institute of the Ministry of Interior and Administration in Warsaw, 02-507 Warsaw, Poland
https://orcid.org/0000-0002-4768-3561
Kamil Poboży
Students’ Scientific Organization of Cancer Cell Biology, Department of Propedeutics of Oncology, Medical University of Warsaw
https://orcid.org/0000-0003-1260-1738
Paweł Domański
Ciechanów Hospital Poland
Marta Fudalej
Department of Propedeutics of Oncology, Medical University of Warsaw
https://orcid.org/0000-0001-8665-2875
Andrzej Deptała
Department of Propedeutics of Oncology, Medical University of Warsaw
https://orcid.org/0000-0003-2640-2043
Anna Badowska-Kozakiewicz
Department of Propedeutics of Oncology, Medical University of Warsaw
https://orcid.org/0000-0002-4640-1606

Abstract

Introduction and objective. E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2.


State of knowledge. Numerous studies have demonstrated a role for E2F2 in various signaling pathways. Certain components of these pathways may serve as potential targets for oncological therapy. E2F2 has been shown to be associated with neoplasms of various locations and histological types (breast, colon, gastric, laryngeal, liver, lung, ovarian, pancreatic, and prostate cancers).


Conclusions. Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments. 

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How to Cite
1.
Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. OncoReview [Internet]. 2023Jul.18 [cited 2024Dec.22];13(2(50):58-6. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/2736
Issue
Vol 13 No 2(50) (2023)
Section
PERSONALIZED ONCOLOGY
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

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