Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer. Original article

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Rafał Oraczewski
Malgorzata Czerniawska-Meler
Martyna Korzeniewicz
Grzegorz Kade
Zygmunt Kozielec
Maciej Michalak
Magdalena Król
Adam Zdaniukiewicz
Lubomir Bodnar


The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.


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Oraczewski R, Czerniawska-Meler M, Korzeniewicz M, Kade G, Kozielec Z, Michalak M, Król M, Zdaniukiewicz A, Bodnar L. Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer. OncoReview [Internet]. 2022Sep.8 [cited 2022Oct.4];12(2(46):25-4. Available from:


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