Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale Original article

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Published: Feb 14, 2021
DOI: https://doi.org/10.24292/01.OR.420010221
Keywords:
ventricular tachycardia, ablation, radiosurgery, STAR, arrhythmia

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Marcin Miszczyk
III Department of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Tomasz Jadczyk
1. Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland. 2. Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic
Bartłomiej Tomasik
Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
Tomasz Latusek
Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Jacek Bednarek
Department of Electrocardiology, John Paul II Hospital, Cracow, Poland
Radosław Kurzelowski
Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
Krzysztof Gołba
1. Department of Electrocardiology, Upper-Silesian Heart Center, Katowice, Poland. 2. Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland
Wojciech Wojakowski
Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
Krystian Wita
First Department of Cardiology, Medical University of Silesia, Katowice, Poland
Łukasz Dolla
Department of Radiotherapy Planning, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Aleksandra Grządziel
Department of Radiotherapy Planning, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
Sławomir Blamek
Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland

Abstract

Patients with ventricular tachycardia are usually treated with antiarrhythmic drugs and ablation if the arrhythmia substrate is available for invasive treatment. Despite high efficiency of this treatment there is a significant group of patients who do not benefit from available treatment methods, either because they cannot be applied or do not allow for durable control of the disease. For that reason a novel treatment method, STereotactic Arrhythmia Radioablation (STAR) has been proposed and its safety and efficiency is extensively studied throughout the world. The method is based on irradiation of the arrhythmia substrate identified with electrophysiological examination with high-precision image-guided radiosurgical methods usually used for ablation of malignant tumors. Here we present the protocol of the first Polish study on STAR in patients with intractable ventricular tachycardia (STARVT, NCT04642963), designed to test the safety of the method. Secondary endpoints include measures of the treatment efficiency.

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How to Cite
1.
Miszczyk M, Jadczyk T, Tomasik B, Latusek T, Bednarek J, Kurzelowski R, Gołba K, Wojakowski W, Wita K, Dolla Łukasz, Grządziel A, Blamek S. Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale. OncoReview [Internet]. 2021Feb.14 [cited 2024Dec.23];10(4(40):123-9. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/1147
Issue
Vol 10 No 4(40) (2020)
Section
CARDIO-ONCOLOGY
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

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