Terapia komórkowa w schorzeniach zwyrodnieniowych siatkówki – nadzieje i zagrożenia Artykuł przeglądowy
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Opublikowane:
mar 31, 2020
Słowa kluczowe:
terapia komórkowa, komórki macierzyste, zwyrodnienie barwnikowe siatkówki
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Abstrakt
Obecnie brakuje skutecznego leczenia przyczynowego wielu chorób degeneracyjnych siatkówki. Za poprawę morfologii i funkcji degenerującej siatkówki odpowiadają czynniki neurotroficzne wydzielane przez aplikowane komórki, które wykazują dodatkowo wpływ immunomodulujący i redukują odpowiedź zapalną uszkodzonej tkanki. Najlepsze efekty uzyskuje się w początkowym stadium zaawansowania choroby. Pomimo obiecujących wstępnych wyników terapia komórkowa wymaga dalszych badań oceniających jej skuteczność i długoterminowe bezpieczeństwo. Ponadto powinna być prowadzona tylko w ramach bezpłatnych badań klinicznych w certyfikowanych ośrodkach naukowo-badawczych po uzyskaniu świadomej zgody pacjenta na leczenie.
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Machalińska A. Terapia komórkowa w schorzeniach zwyrodnieniowych siatkówki – nadzieje i zagrożenia. Ophthatherapy [Internet]. 31 marzec 2020 [cytowane 22 listopad 2024];7(1):30-5. Dostępne na: https://journalsmededu.pl/index.php/ophthatherapy/article/view/972
Numer
Dział
Terapie zachowawcze
Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne – Bez utworów zależnych 4.0 Międzynarodowe.
Copyright: © Medical Education sp. z o.o. License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
Bibliografia
1. Mandai M, Watanabe A, Kurimoto Y et al. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017; 376(11): 1038-46.
2. Machalińska A, Karczewicz D, Machaliński B. Stem cells – new perspectives in the treatment of retinal disorders. Klin Oczna. 2006; 108(10-12): 471-4.
3. Machalińska A, Baumert B, Kuprjanowicz L et al. Potential application of adult stem cells in retinal repair – challenge for regenerative medicine. Curr Eye Res. 2009; 34(9): 748-60.
4. Machalińska A, Zuba-Surma EK. Stem cells in adult retina – current state of research, future therapeutic prospects. Klin Oczna. 2009; 111(7-9): 253-7.
5. Machalińska A, Kłos P, Baumert B et al. Stem cells are mobilized from the bone marrow into the peripheral circulation in response to retinal pigment epithelium damage – a pathophysiological attempt to induce endogenousregeneration. Curr Eye Res. 2011; 36(7): 663-72.
6. Machalińska A, Lubiński W, Penkala K et al. Functional improvement of injured retina following the adjuvant stem cell-based therapy. Preliminary report. Klin Oczna. 2011; 113(4-6): 117-21.
7. Machalińska A, Kawa M, Pius-Sadowska E et al. Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injectedintravitreally in a mouse model of acute retinal injury. Invest Ophthalmol Vis Sci. 2013; 54(13): 8292-305.
8. Sobieniecki A, Machalińska A, Rogińska D et al. Slow retinal degeneration in a mouse model: morphological and functional aspects. Pomeranian J Life Sci. 2015; 61(1): 81-9.
9. Machalińska A, Rogińska D, Pius-Sadowska E et al. Neuroprotective and antiapoptotic activity of lineage-negative bone marrow cells after intravitrealinjection in a mouse model of acute retinal injury. Stem Cells Int. 2015; 2015: 620364.
10. Paczkowska E, Kaczyńska K, Pius-Sadowska E et al. Humoral activity of cord blood-derived stem/progenitor cells: implications for stem cell-based adjuvant therapy of neurodegenerative disorders. PLoS One. 2013; 8: e83833.
11. Lejkowska R, Kawa MP, Pius-Sadowska E et al. Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered MesenchymalStromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice. Int J Mol Sci. 2019; 20(3): 777.
12. Kerschensteiner M. Neuroprotective approaches in the animal model. Drug Res (Stuttg). 2013; 63(suppl 1): S7.
13. Wenzel A, Grimm C, Samardzija M et al. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005; 24(2): 275-306.
14. Siqueira RC, Messias A, Gurgel VP et al. Improvement of ischaemic macular oedema after intravitreal injection of autologous bone marrow-derived haematopoietic stem cells. Acta Ophthalmol. 2015; 93(2): e174-6.
15. Siqueira RC, Messias A, Voltarelli JC et al. Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation. Bone Marrow Transplant. 2013; 48(4): 612-3.
16. Park SS, Bauer G, Abedi M et al. Intravitreal autologous bone marrow cd34+ cell therapy for ischemic and degenerative retinal disorders: Preliminary phase 1 clinical trial findings. Investig Ophthalmol Vis Sci. 2015; 56(1): 81-9.
17. Cotrim CC, Toscano L, Messias A et al. Intravitreal use of bone marrow mononuclear fraction containing CD34+stem cells in patients with atrophic age-related macular degeneration. Clin Ophthalmol. 2017; 11: 931-8.
18. Weiss JN, Levy S. Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of Retinitis Pigmentosa. Stem Cell Investig. 2018; 5: 18.
19. Weiss JN, Levy S. Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow derived stem cells in the treatment of Usher syndrome. Stem Cell Investig. 2019; 6: 31.
20. Kim JY, You YS, Kim SH et al. Epiretinal Membrane Formation After Intravitreal Autologous Stem Cell Implantation in a Retinitis Pigmentosa Patient. Retin Cases Brief Rep. 2017; 11(3): 227-31.
21. Boudreault K, Justus S, Lee W et al. Complication of Autologous Stem Cell Transplantation in Retinitis Pigmentosa. JAMA Ophthalmol. 2016; 134(6): 711-2.
22. Kuriyan AE, Albini TA, Townsend JH et al. Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD. N Engl J Med. 2017; 376(11): 1047-53.
23. Souied E, Pulido J, Staurenghi G. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017; 377(8): 792.
2. Machalińska A, Karczewicz D, Machaliński B. Stem cells – new perspectives in the treatment of retinal disorders. Klin Oczna. 2006; 108(10-12): 471-4.
3. Machalińska A, Baumert B, Kuprjanowicz L et al. Potential application of adult stem cells in retinal repair – challenge for regenerative medicine. Curr Eye Res. 2009; 34(9): 748-60.
4. Machalińska A, Zuba-Surma EK. Stem cells in adult retina – current state of research, future therapeutic prospects. Klin Oczna. 2009; 111(7-9): 253-7.
5. Machalińska A, Kłos P, Baumert B et al. Stem cells are mobilized from the bone marrow into the peripheral circulation in response to retinal pigment epithelium damage – a pathophysiological attempt to induce endogenousregeneration. Curr Eye Res. 2011; 36(7): 663-72.
6. Machalińska A, Lubiński W, Penkala K et al. Functional improvement of injured retina following the adjuvant stem cell-based therapy. Preliminary report. Klin Oczna. 2011; 113(4-6): 117-21.
7. Machalińska A, Kawa M, Pius-Sadowska E et al. Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injectedintravitreally in a mouse model of acute retinal injury. Invest Ophthalmol Vis Sci. 2013; 54(13): 8292-305.
8. Sobieniecki A, Machalińska A, Rogińska D et al. Slow retinal degeneration in a mouse model: morphological and functional aspects. Pomeranian J Life Sci. 2015; 61(1): 81-9.
9. Machalińska A, Rogińska D, Pius-Sadowska E et al. Neuroprotective and antiapoptotic activity of lineage-negative bone marrow cells after intravitrealinjection in a mouse model of acute retinal injury. Stem Cells Int. 2015; 2015: 620364.
10. Paczkowska E, Kaczyńska K, Pius-Sadowska E et al. Humoral activity of cord blood-derived stem/progenitor cells: implications for stem cell-based adjuvant therapy of neurodegenerative disorders. PLoS One. 2013; 8: e83833.
11. Lejkowska R, Kawa MP, Pius-Sadowska E et al. Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered MesenchymalStromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice. Int J Mol Sci. 2019; 20(3): 777.
12. Kerschensteiner M. Neuroprotective approaches in the animal model. Drug Res (Stuttg). 2013; 63(suppl 1): S7.
13. Wenzel A, Grimm C, Samardzija M et al. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005; 24(2): 275-306.
14. Siqueira RC, Messias A, Gurgel VP et al. Improvement of ischaemic macular oedema after intravitreal injection of autologous bone marrow-derived haematopoietic stem cells. Acta Ophthalmol. 2015; 93(2): e174-6.
15. Siqueira RC, Messias A, Voltarelli JC et al. Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation. Bone Marrow Transplant. 2013; 48(4): 612-3.
16. Park SS, Bauer G, Abedi M et al. Intravitreal autologous bone marrow cd34+ cell therapy for ischemic and degenerative retinal disorders: Preliminary phase 1 clinical trial findings. Investig Ophthalmol Vis Sci. 2015; 56(1): 81-9.
17. Cotrim CC, Toscano L, Messias A et al. Intravitreal use of bone marrow mononuclear fraction containing CD34+stem cells in patients with atrophic age-related macular degeneration. Clin Ophthalmol. 2017; 11: 931-8.
18. Weiss JN, Levy S. Stem Cell Ophthalmology Treatment Study: bone marrow derived stem cells in the treatment of Retinitis Pigmentosa. Stem Cell Investig. 2018; 5: 18.
19. Weiss JN, Levy S. Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow derived stem cells in the treatment of Usher syndrome. Stem Cell Investig. 2019; 6: 31.
20. Kim JY, You YS, Kim SH et al. Epiretinal Membrane Formation After Intravitreal Autologous Stem Cell Implantation in a Retinitis Pigmentosa Patient. Retin Cases Brief Rep. 2017; 11(3): 227-31.
21. Boudreault K, Justus S, Lee W et al. Complication of Autologous Stem Cell Transplantation in Retinitis Pigmentosa. JAMA Ophthalmol. 2016; 134(6): 711-2.
22. Kuriyan AE, Albini TA, Townsend JH et al. Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD. N Engl J Med. 2017; 376(11): 1047-53.
23. Souied E, Pulido J, Staurenghi G. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017; 377(8): 792.