How do we treat and where do we go in AMD treatment

Main Article Content

Anna Święch-­Zubilewicz
Joanna Dolar-Szczasny
Jerzy Mackiewicz

Abstract

The number of patients with age­related macular degeneration in population over 50 increases constantly, however the exact etiology of that pathology is still not well known. Previously used wet AMD treatment methods such as radiotherapy, laser therapy or photodynamic therapy were not successful. Now the gold standard for wet AMD treatment is the use of intravitreally administered anti­VEGF antagonists such as ranibizumab, aflibercept or off­label bevacizumab. However these medications are directed against the symptoms and not the cause of described pathology. Probable multifactorial etiology of AMD needs further improvement in therapy of that disease. New immunomodulators, neuroprotectors, antioxidants as well as gene therapy is currently under investigations to improve AMD treatment

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Święch-­Zubilewicz A, Dolar-Szczasny J, Mackiewicz J. How do we treat and where do we go in AMD treatment. Ophthatherapy [Internet]. 2014Mar.31 [cited 2024Nov.22];1(1):4-10. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/662
Section
Articles

References

1. Aiello LP, Northrup JN, Keyt BA et al. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch Ophthalmol. 1995; 113(12): 1538-44.
2. Aird WC. Endothelial cell heterogeneity. Crit Care Med. 2003; 31: 221-30.
3. Arnold JJ, Blinder KJ, Bressler NM et al. Treatment of age-related macular degeneration with Photodynamic Therapy Study Group. Acute severe visual acuity decrease after photodynamic therapy with verterporfiryn: case report from randomized clinical trials-TAP and VIP report. Am J Ophthalmol. 2004; 137: 683-96.
4. Bressler NM. Early detection and treatment of neovascular age-related macular degeneration. J Am Board Pract. 2002; 15(2): 142-52.
5. Ciulla TA, Danis RP, Harris A. Age-related macular degeneration: A review of experimental treatments. Surv Ophthalmol. 1998; 43(2): 134-46.
6. Das A, Mc Guire PG. Retinal and choroidal angiogenesis: Pathophysiology and strategies for inhibition. Prog Retin Eye Res. 2003; 22(6): 721-48.
7. Ferrara N, Gerber HP, LeCouter J. The biology of vascular endothelial growth factor. Endocr Rev. 2003; 18(1): 4-25.
8. Fine SL, Berger JW, Maguire MG et al. Age-related macular degeneration and blindness due to neovascular maculopathy. N Engl J Med. 2000; 342(7): 483-92.
9. Gilies MC, Simpson JM, Luo W et al. A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration; one year results. Arch Ophthalmol. 2003; 121: 667-73.
10. Grossniklaus HE, Green WR. Choroidal neovascularisation. Am J Ophthalmol. 2004; 137: 496-503.
11. Hubschman JP, Reddy S, Schwartz SD. Age-related macular degeneration: experimental and emerging treatments. Clin Ophthalmol. 2009; 3: 167-74.
12. Hue J, Spee C, Kase S et al. Recombinant human VEGF 165 b inhibits experimental choroidal neovascularisation. IOVS. 2010; 51(8): 4282-8.
13. Jager RD, Aiello LP, Patel CS et al. Risks of intravitreus injection: a comprehensive review. Retina. 2004; 24: 676-98.
14. Liu M, Regillo CD. A review of treatments for macular degeneration: a synopsis of currently approved treatments and ongoing clinical trials. Curr Opin Ophthalmol. 2004; 15: 221-6.
15. Papadopoulos N, Martin J, Ruan Q et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012: 15(2): 171-85.
16. Patel S. Combination therapy for age-related macular degeneration. Retina. 2009; 29(6): 45-8.
17. Schmidt-Erfurth U, Kaiser PK, Korobelnik JF. Intravitreal aflibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies. Ophthalmology. 2014; 121(1): 193-201.
18. Serini S, Piccioni E, Calviello G. Dietary n-3 PUFA vascular targeting and the prevention of tumor growth and age-related macular degeneration. Curr Med Chem. 2009; 16(34): 4511-26.
19. Weber BH, Charbel Issa P, Pauly D et al. The role of the complement system in age-related macular degeneration. Dtsch Arztebl Int. 2014; 11(8): 133-8.