Intravitreal ranibizumab injections as a treatment of diabetic macular edema
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Published:
Dec 31, 2015
Keywords:
diabetic macular edema, anti-VEGF treatment, ranibizumab
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Abstract
Diabetic macular edema is a main cause of visual impairment in diabetic patients. Its pathogenesis seems to be multifactorial. Several therapeutic options have been accepted for the treatment of this disease. In this publication we present the newest results of efficacy of intravitreal ranibizumab therapy, as a one, that have revolutionised diabetic macular edema management.
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Prokopiuk A, Zubilewicz A, Latalska M, Mackiewicz J. Intravitreal ranibizumab injections as a treatment of diabetic macular edema. Ophthatherapy [Internet]. 2015Dec.31 [cited 2024Nov.22];2(4):272-6. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/653
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References
1. Mitchell P, Yin Wong T. Perspective management paradigms for diabetic macular edema. Am J Ophthalmol. 2014; 157(3): 505-13.
2. Zasady postępowania w cukrzycowym obrzęku plamki. Wytyczne Polskiego Towarzystwa Okulistycznego 2014.
3. Rotsos TG, Moschos MM. Cystoid macular edema. Journal of Clinical Ophthalmology. 2008; 2(4): 919-30.
4. Bhagat N, Grigorian RA, Tutela A et al. Diabetic macular edema: pathogenesis and treatment. Survey of Ophthalmology. 2009; 54(1): 1-32.
5. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. EDTRS report number 1. Arch Ophthalmol. 1985; 103(12): 1796-806.
6. Schmidt-Erfurth U, Lang GE, Holz FG et al.; RESTORE Extension Study Group. Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study. Ophthalmology. 2014; 121(5): 1045-53.
7. Zhang Y, Yao Z, Kaila N et al. Pharmacokinetics of Ranibizumab after Intravitreal Administration in Patients with Retinal Vein Occlusion or Diabetic Macular Edema. Ophthalmology. 2014; 121(11): 2237-46.
8. Elman MJ, Bressler NM, Qin H et al. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2011; 118(4): 609-14.
9. Nguyen QD, Brown DM, Marcus DM et al; on behalf of the RISE and RIDE Research Group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012; 119(4): 789-801.
10. Brown DM, Nguyen QD, Marcus DM et al; on behalf of the RIDE and RISE Research Group. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology. 2013; 120(10): 2013-22.
11. Nguyen QD, Shah SM, Khwaja AA et al.; READ-2 Study Group. Two-year outcomes of the ranibizumab for edema of the mAcula in Diabetes (READ-2) study. Ophthalmology. 2010; 117(11): 2146-51.
12. Massin P, Bandello F, Garweg JG et al. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care. 2010; 33(11): 2399-405.
13. Mitchell P, Bandello F, Schmidt-Erfurth U et al; on behalf of the RESTORE Study Group. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology. 2011; 118: 615-25.
14. Domalpally A, Ip MS, Ehrlich JS. Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: findings from the RIDE and RISE phase III clinical trials. Ophthalmology. 2015; 122(4): 779-86.
15. Boyer DS, Nguyen QD, Brown DM et al. RIDE and RISE Research Group Outcomes with As-Needed Ranibizumab after Initial Monthly Therapy: Long-Term Outcomes of the Phase III RIDE and RISE Trials. Ophthalmology. 2015 Oct 6. pii: S0161-6420(15)00783-6.
16. Pearce I, Banerjee S, Burton BJ et al.; RELIGHT Study Group. Ranibizumab 0.5 mg for Diabetic Macular Edema with Bimonthly Monitoring after a Phase of Initial Treatment: 18-Month, Multicenter, Phase IIIB RELIGHT Study. Ophthalmology. 2015; 122(9): 1811-9.
17. Sadiq MA, Soliman MK, Sarwar S et al; READ-3 Study Group. Effect of Vitreomacular Adhesion on Treatment Outcomes in the Ranibizumab for Edema of the Macula in Diabetes (READ-3) Study. Ophthalmology. 2015 Oct 28. pii: S0161 6420(15)01110-0 [epub ahead of print].
18. Ishibashi T, Li X, Koh A et al.; REVEAL Study Group. The REVEAL Study: Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema. Ophthalmology. 2015; 122(7): 1402-15.
2. Zasady postępowania w cukrzycowym obrzęku plamki. Wytyczne Polskiego Towarzystwa Okulistycznego 2014.
3. Rotsos TG, Moschos MM. Cystoid macular edema. Journal of Clinical Ophthalmology. 2008; 2(4): 919-30.
4. Bhagat N, Grigorian RA, Tutela A et al. Diabetic macular edema: pathogenesis and treatment. Survey of Ophthalmology. 2009; 54(1): 1-32.
5. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. EDTRS report number 1. Arch Ophthalmol. 1985; 103(12): 1796-806.
6. Schmidt-Erfurth U, Lang GE, Holz FG et al.; RESTORE Extension Study Group. Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study. Ophthalmology. 2014; 121(5): 1045-53.
7. Zhang Y, Yao Z, Kaila N et al. Pharmacokinetics of Ranibizumab after Intravitreal Administration in Patients with Retinal Vein Occlusion or Diabetic Macular Edema. Ophthalmology. 2014; 121(11): 2237-46.
8. Elman MJ, Bressler NM, Qin H et al. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2011; 118(4): 609-14.
9. Nguyen QD, Brown DM, Marcus DM et al; on behalf of the RISE and RIDE Research Group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology. 2012; 119(4): 789-801.
10. Brown DM, Nguyen QD, Marcus DM et al; on behalf of the RIDE and RISE Research Group. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology. 2013; 120(10): 2013-22.
11. Nguyen QD, Shah SM, Khwaja AA et al.; READ-2 Study Group. Two-year outcomes of the ranibizumab for edema of the mAcula in Diabetes (READ-2) study. Ophthalmology. 2010; 117(11): 2146-51.
12. Massin P, Bandello F, Garweg JG et al. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care. 2010; 33(11): 2399-405.
13. Mitchell P, Bandello F, Schmidt-Erfurth U et al; on behalf of the RESTORE Study Group. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology. 2011; 118: 615-25.
14. Domalpally A, Ip MS, Ehrlich JS. Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: findings from the RIDE and RISE phase III clinical trials. Ophthalmology. 2015; 122(4): 779-86.
15. Boyer DS, Nguyen QD, Brown DM et al. RIDE and RISE Research Group Outcomes with As-Needed Ranibizumab after Initial Monthly Therapy: Long-Term Outcomes of the Phase III RIDE and RISE Trials. Ophthalmology. 2015 Oct 6. pii: S0161-6420(15)00783-6.
16. Pearce I, Banerjee S, Burton BJ et al.; RELIGHT Study Group. Ranibizumab 0.5 mg for Diabetic Macular Edema with Bimonthly Monitoring after a Phase of Initial Treatment: 18-Month, Multicenter, Phase IIIB RELIGHT Study. Ophthalmology. 2015; 122(9): 1811-9.
17. Sadiq MA, Soliman MK, Sarwar S et al; READ-3 Study Group. Effect of Vitreomacular Adhesion on Treatment Outcomes in the Ranibizumab for Edema of the Macula in Diabetes (READ-3) Study. Ophthalmology. 2015 Oct 28. pii: S0161 6420(15)01110-0 [epub ahead of print].
18. Ishibashi T, Li X, Koh A et al.; REVEAL Study Group. The REVEAL Study: Ranibizumab Monotherapy or Combined with Laser versus Laser Monotherapy in Asian Patients with Diabetic Macular Edema. Ophthalmology. 2015; 122(7): 1402-15.