Improvement of the therapeutic effect in age-related macular degeneration after switching therapy from aflibercept to ranibizumab

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Published: Jun 30, 2017
DOI: https://doi.org/10.24292/01.ot.300617.03
Keywords:
age-related macular degeration, aflibercept, ranizbizumab

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Anna Hyjek-Ryś
Wojewódzki Szpital Okulistyczny w Krakowie
Maciej Kozak
Wojewódzki Szpital Okulistyczny w Krakowie
Ilona Pawlicka
Wojewódzki Szpital Okulistyczny w Krakowie
Grażyna Miklaszewska
Wojewódzki Szpital Okulistyczny w Krakowie

Abstract

The aim of the study: To evaluate anatomic and functional effects as well as the individual susceptibility to ranibizumab therapy in the absence of beneficial effects of aflibercept treatment in age-related macular degeneration.


Material and Method: Ten patients, unsuccessfully treated with intravitreal aflibercept injections, were qualified for the ranibizumab injection program in AMD treatment. Ineffective treatment was understood as an increase in macular edema, and the resultant increase in central retinal thickness, and increased leakage in fluorescein angiography with an accompanying decrease in visual acuity and progression of changes on the Amsler grid. Following the treatment with ranibizumab injections, the above mentioned parameters were subject to further control.


Results: Three patients experienced a reduction in central retinal thickness, edema and leakage area in fluorescein angiography, accompanied by reduced metamorphosis on the Amsler grid and stabilization or improvement of the best corrected visual acuity.


Conclusion: The conversion of aflibercept therapy to ranibizumab therapy may be valuable for patients with no effective treatment with aflibercept. The problem requires further follow-up and assessment. Final conclusions might help design better methods for individual patient selection.

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How to Cite
1.
Hyjek-Ryś A, Kozak M, Pawlicka I, Miklaszewska G. Improvement of the therapeutic effect in age-related macular degeneration after switching therapy from aflibercept to ranibizumab. Ophthatherapy [Internet]. 2017Jun.30 [cited 2024Nov.22];4(2):85-1. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/563
Issue
Vol 4 No 2 (2017)
Section
Articles
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