The use of nonsteroidal anti-inflammatory drugs in the treatment of macular edema in eyes after pars plana vitrectomy with silicon oil endotamponade – a case series report

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Izabella Karska-Basta
Bożena Romanowska-Dixon
Agnieszka Kubicka-Trząska

Abstract

The aim of the study: To evaluate the influence of ophthalmic suspension of nepafenac on the central retina edema.


Material and method: Three patients treated with a topical nonsteroidal anti- inflammatory drug nepafenac 0.1% ophthalmic suspension for the reduction of postoperative macular edema associated with pars plana vitrectomy with silicon oil endotamponade. In all patients macular morphology was assessed using optical coherence tomography and best corrected visual acuity with Snellen charts.


Results: Improvement of macular morphology and central retinal thickness reduction were observed in all patients. Best corrected visual acuity remained unchanged during the follow-up period.


Conclusion: Based on our observations we suggest that the involvement of the vitreous body in the distribution of ophthalmic suspension of a topical nonsteroidal anti-inflammatory drug within the posterior segment of the eye does not seem to be significant.

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1.
Karska-Basta I, Romanowska-Dixon B, Kubicka-Trząska A. The use of nonsteroidal anti-inflammatory drugs in the treatment of macular edema in eyes after pars plana vitrectomy with silicon oil endotamponade – a case series report. Ophthatherapy [Internet]. 2016Sep.30 [cited 2024May3];3(3):172-7. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/607
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References

1. Lane SS, Modi SS, Lehmann RP et al. Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg. 2007; 33: 53-8.
2. Hariprasad SM, Callanan D, Gainery S et al. Cystoid and diabetic macular edema treated with nepafenac 0.1%. J Ocul Pharmacol Ther. 2007; 23: 585-90.
3. Singh R, Alpern L, Jaffe GJ et al. Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. Clin Ophthalmol. 2012; 6: 1259-69.
4. Wolf EJ, Braunstein A, Shih C et al. Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac. J Cataract Refract Surg. 2007; 33: 1546-9.
5. Walters T, Raizman M, Ernest P et al. In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J Cataract Refract Surg. 2007; 33: 1539-45.
6. Gamache A, Graff G, Brady MT et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000; 24: 357-70.
7. Flach AJ. Cyclo-oxygenase inhibitors in ophthalmology. Surv Ophthalmol. 1992; 36: 259-84.
8. Smyth EM, Fitzgerald GA. The eicosanoids: prostaglandins, thromboxanes, leukotrienes & related compounds. In: Katzung B. (ed). Basic and Clinical Pharmacology. McGraw Hill, New York 2007: 293-308.
9. Kapin MA, Yanni JM, Brady MT et al. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Inflammation. 2003; 27: 281-91.
10. Ke TL, Graff G, Spellman JM et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation. 2000; 24: 371-84.
11. Kulkarni PS, Srinivasan BD. Cyclooxygenase and lipoxygenase pathways in anterior uvea and conjunctiva. Prog Clin Biol Res. 1989; 312: 39-52.
12. Radi ZA, Render JA. The pathophysiologic role of cyclooxygenases in the eye. J Ocul Pharmacol Ther. 2008; 24: 141-51.
13. Lindstrom R, Kim T. Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. Curr Med Res Opin. 2006; 22: 397-404.
14. Bucolo C, Marrazzo G, Platania CBM et al. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. J Pharm Pharmacol. 2014; 66: 954-60.
15. Koevary SB. Pharmacokinetics of topical ocular drug delivery: potential uses for the treatment of diseases of the posterior segment and beyond. Curr Drug Metab. 2003; 4: 213-22.
16. Maurice DM, Mishima S. Ocular pharmacokinetics. In: Sears ML (ed). Pharmacology of the Eye: Handbook of Experimental Pharmacology. Springer-Verlag, Berlin 1986: 19-116.
17. Maurice DM. Drug delivery to the posterior segment from drops. Surv Ophthamol. 2002; 47: 41-52.
18. Hughes PM, Olejnik O, Chang-Lin JE et al. Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev. 2005; 57: 2010-32.
19. Chastain JE, Sanders ME, Curtis MA et al. Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye. Exp Eye Res. 2016; 145: 58-67.
20. Nardi M, Lobo C, Bereczki A et al. Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery Clin Ophthalmol. 2007; 1: 527-33.
21. Modi SS, Lehmann RP, Walters TR et al. Once-daily nepafenac ophthalmic suspension 0.3% to prevent and treat ocular inflammation and pain after cataract surgery: phase 3 study. J Cataract Refract Surg. 2014; 40: 203-11.