Scleritis in systemic diseases Review article
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Abstract
This paper discusses scleritis in the course of systemic autoimmune diseases such as rheumatoid arthritis, nodular arteritis and granulomatosis with vasculitis. In addition, treatment suggestions based on the available literature are presented. Patients with scleritis resulting from an underlying disease should be twardiagnosed as soon as possible and given appropriate and effective treatment. Untreated or poorly treated scleritis or underlying disease can lead to severe damage to ocular tissues, loss of vision and eventually even blindness. A meticulous medical history, detailed ophthalmic examination and a series of targeted investigations as part of a multidisciplinary approach to detect any systemic disease are important in the management of scleritis. Rheumatoid arthritis remains the most common systemic rheumatic disease and the most common systemic condition associated with scleritis.
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References
2. Vergouwen DPC, Rothova A, Berge JCT et al. Current insights in the pathogenesis of scleritis. Exp Eye Res. 2020; 197: 108078.
3. Czaplicka E. Objawy okulistyczne w przebiegu chorób reumatycznych. In: Wielka Interna. Reumatologia. Wyd. II. Puszczewicz M (ed.). Medical Tribune Polska, Warszawa 2016.
4. Abdel-Aty A, Gupta A, Del Priore L et al. Management of noninfectious scleritis. Ther Adv Ophthalmol. 2022; 14: 25158414211070879.
5. Promelle V, Goeb V, Gueudry J. Rheumatoid Arthritis Associated Episcleritis and Scleritis: An Update on Treatment Perspectives. J Clin Med. 2021; 10(10): 2118. http://doi.org/10.3390/jcm10102118.
6. Filipowicz-Sosnowska A. VII; D; 1. Reumatoidalne zapalenie stawów. In: Interna Szczeklika 2020. Gajewski P (ed.). Medycyna Praktyczna, Kraków 2020: 2030-45.
7. Islam MA, Khandker SS, Kotyla PJ et al. Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review. Front Immunol. 2020; 11: 1477. http://doi.org/10.3389/fimmu.2020.01477.
8. Silpa-archa S, Lee JJ, Foster CS. Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol. 2016; 100(1): 135-41. http://doi.org/10.1136/bjophthalmol-2015-306629.
9. Heron E, Gutzwiller-Fontaine M, Bourcier T. Scleritis and episcleritis: diagnosis and treatment. Rev Med Interne. 2014; 35: 577-85. http://doi.org/10.1016/j.revmed.2014.02.004.
10. Moin KA, Yeakle MM, Parrill AM et al. Ocular and orbital manifestations of granulomatosis with polyangiitis: a systematic review of published cases. Rom J Ophthalmol. 2023; 67(3): 214-21. http://doi.org/10.22336/rjo.2023.38.
11. Cleary JO, Sivarasan N, Burd C et al. Head and neck manifestations of granulomatosis with polyangiitis. Br J Radiol. 2021; 94(1119): 20200914. http://doi.org/10.1259/bjr.20200914.
12. Říhová E, Svozílková P, Brichová M et al. Ocular Manifestations of Granulomatosis with Polyangiitis. Oční projevy granulomatózy s polyangiitidou. Cesk Slov Oftalmol. 2019; 74(5): 167-74. http://doi.org/10.31348/2018/5/1.
13. Musiał J, Szczeklik A, Sznajd J. VII; D; 10.2.1.2. Ziarniniakowatość z zapaleniem naczyń. In: Interna Szczeklika 2020. Gajewski P. (ed.). Wydawnictwo Medycyna Praktyczna, Kraków 2020: 2085-88.
14. Lee AB, Charoenkijkajorn C, Stoutin J et al. Neuro-ophthalmic manifestations of Polyarteritis Nodosa. Eyewiki .
15. Akova YA, Jabbur NS, Foster CS. Ocular presentation of polyarteritis nodosa. Clinical course and management with steroid and cytotoxic therapy. Ophthalmology. 1993; 100(12): 1775-81. http://doi.org/10.1016/s0161-6420(93)31405-3.
16. Vazquez-Romo KA, Rodriguez-Hernandez A, Paczka JA et al. Optic Neuropathy Secondary to Polyarteritis Nodosa, Case Report, and Diagnostic Challenges. Front Neurol. 2017; 8: 490. http://doi.org/10.3389/fneur.2017.00490.
17. Eleftheriou D, Melo M, Marks SD et al. Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford). 2009; 48(8): 978-86. http://doi.org/10.1093/rheumatology/kep148.
18. Lagina A, Ramphul K. Scleritis. In: StatPearls. StatPearls Publishing, Treasure Island (FL) 2023.
19. Dutta Majumder P, Agrawal R, McCluskey P et al. Current Approach for the Diagnosis and Management of Noninfective Scleritis. Asia Pac J Ophthalmol (Phila). 2020; 10(2): 212-23. http://doi.org/10.1097/APO.0000000000000341.
20. Murthy SI, Sabhapandit S, Balamurugan S et al. Scleritis: Differentiating infectious from non-infectious entities. Indian J Ophthalmol. 2020; 68(9): 1818-28. http://doi.org/10.4103/ijo.IJO_2032_20.