Latanoprost drops without added detergent in the treatment of glaucoma Commentary
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Abstract
Chronic nature of both the disease and its therapy forces ophthalmologists to choose the treatment with the lowest potential for adverse reactions, which may be caused by the active substance, excipient or preservative. Detergents used in ophthalmic drops include a derivative of macrogolglycerol hydroxystearate-40 (MGHS-40), which in in vitro tests showed pro-inflammatory and cytotoxic properties towards corneal epithelial cells, and this effect increased with increasing concentration and time. The analyzed observational study showed that latanoprost without MGHS-40 effectively reduces intraocular pressure, and the factors encouraging ophthalmologists to choose this preparation were good local tolerance and a simple composition (without detergents, preservatives and antioxidants), improving compliance. In the observational study, 82.3% received latanoprost without MGHS-40, and almost 60% started antiglaucoma treatment with this preparation.
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