Troxerutin in the treatment of eye diseases – a proven substance rediscovered Review article
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Abstract
Troxerutin is a well and for a long time known substance, it is a semi-synthetic bioflavonoid derived from rutin. Original substance is supplied from flowers of Styphnolobium japonicum tree.
The author discusses actual medical effects of troxerutin, including antioxidant, anti-inflammatory, antithrombosis and protecting endothelium of small vessels.
Being water-soluble, it can be used as ophthalmic drops in treatment of subconjunctival haemorrhage, vitreous haemorrhage and early stages of diabetic retinopathy.
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References
2. He H, Bai Y, Zhao Z et al. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L. J Ethnopharmacol. 2016; 187: 160-82.
3. Zamanian M, Bezmandegan G, Sureda A et al. The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review. Curr Neuropharmacol. 2021; 19: 97-110.
4. Fahmideh F, Marchesi N, Campagnoli LIM et al. Effect of troxerutin in counteracting hyperglycemia-induced VEGF upregulation in endothelial cells: a new option to target early stages of diabetic retinopathy? Front Pharmacol. 2022; 13: 951833.
5. Ahmadi Z. Mohammadinejad R, Roomiani S et al. Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View. J Pharmacopuncture. 2021; 24: 1-13.
6. Qadiri A, Bavil FM, Hamidian GR et al. Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. Avicenna J Phytomed. 2019; 9: 374-85.
7. Aziz Z, Tang WL, Chong NJ et al. A systematic reviev of the efficacy and tolerability of hydroxyethylorutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015; 40: 177-85.
8. Nonikashvili Z, Jūratė Gerbutavičienė R. Ginkgo biloba, troxerutin and heptaminol chlorhydrate combined treatment for the management of venous insufficiency and hemorrhoidal crises. Eur Rev Med Pharmacol Sci. 2022; 26: 5200-9.
9. Tash NG, Cimen FK, Karakurt Y et al. Protective effects of Rutin against methanol induced acute toxic neuropathy: an experimental study. Int J Ophthalmol. 2018; 11: 780-5.
10. Celik A, Ersoy OF, Ozkan N et al. Comparison of effects of troxerutin and heparinoid on flap necrosis. J Plast Reconstr Aesthet Surg. 2010; 63: 875-83.
11. Glacet-Bernard A, Coscas G, Chabanel A et al. A Randomized, Double-Masked study of the Treatment od Retinal Vein Occlusin With Troxerutin. AJO. 1994; 118: 421-9.
12. Kaul A, Short WD, Wang X et al. Hyaluronidases in Human Diseases. Int J Mol Sci. 2021; 22: 3204.
13. Wang C, Pang Y. Nano-based eye drop: Topical and noninvasive therapy for ocular diseases. Adv Drug Deliv Rev. 2023; 194: 114721.