An unusual presentation of corneal intraepithelial neoplasia Case report

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Paula Marticorena-Álvarez
Guadalupe Garrido Ceca
Diego Asensio Celdrán Vivancos


Introduction: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion.
Clinical case: An 80-year-old woman with an elevated, avascular, well-demarcated grey corneal plaque. After epitheliectomy and alcohol, the excised lesion was identified as a high-grade epithelial neoplasia. Treatment was topical interferon α-2b for 1 month without recurrences.
Conclusions: A well-defined greyish corneal opacity should always raise suspicion of an intraepithelial neoplasia. In the present case, epitheliectomy and topical recombinant interferon proved successful.

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Marticorena-Álvarez P, Garrido Ceca G, Celdrán Vivancos DA. An unusual presentation of corneal intraepithelial neoplasia. Ophthatherapy [Internet]. 2020Dec.23 [cited 2021Mar.5];7(4):302-4. Available from:
Conservative treatment


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