MicroRNA in the pathogenesis of glaucoma Review article

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Karolina Gasińska
Ewa Kosior-Jarecka
Tomasz Żarnowski


MicroRNAs are short ribonucleic acid molecules that regulate gene expression. The involvement of various types of microRNAs in the pathogenesis of glaucoma has been proved. Most of them affect trabecular meshwork in the anterior chamber angle, causing excessive deposition of extracellular matrix and blockage of the aqueous humor outflow. MicroRNAs affect the contractility of the trabecular meshwork cells, decreasing its permeability and increasing intraocular pressure. They participate in the regulation of apoptosis of trabecular meshwork cells and retinal ganglion cells. MicroRNAs may be potential biomarkers for glaucoma and, in the future, a target for gene therapy.

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Gasińska K, Kosior-Jarecka E, Żarnowski T. MicroRNA in the pathogenesis of glaucoma. Ophthatherapy [Internet]. 2020Dec.9 [cited 2021Mar.5];7(4):277-86. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/1108


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