Perspectives of clinical applications of RENEXUS® implants in macular telangiectasia type 2 Review article

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Agnieszka Nowosielska


The intraocular RENEXUS® implant, manufactured by Neurotech Pharmaceuticals, represents a new-generation ophthalmic product with regard to its active chemical substance and mode of the intraocular delivery system. The active compound of the implant, ciliary neurotrophic factor (CNTF), is produced by human retinal pigment epithelium cells that are encapsulated within the device. Ciliary neurotrophic factor has protective effects on retinal cells that help delay their degeneration in chronic retinal degenerative disorders and cases of prolonged ischemia. RENEXUS® implants may be useful for the treatment of macular telangiectasia type 2, retinitis pigmentosa, glaucoma, neuropathy, anterior ischemic neuropathy, and age-related macular degeneration. The active time of CNTF secretion after implantation is approximately 5 years.

Intraocular RENEXUS® implants were evaluated in a Phase II clinical trial and have now been tested in a double-blind placebo-controlled clinical trial of macular telangiectasia type 2.

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Nowosielska A. Perspectives of clinical applications of RENEXUS® implants in macular telangiectasia type 2. Ophthatherapy [Internet]. 2020Jun.30 [cited 2020Oct.21];7(2):142-7. Available from:
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