Adalimumab therapy of noninfectious uveitis Review article

Main Article Content

Julia Kręcicka
Anna Turno-Kręcicka
Marta Misiuk-Hojło


Noninfectious uveitis is known for its chronic and cumulative nature. It is often associated with diagnostic and therapeutic difficulties. It causes significant vision loss in young patients, making them incapable of maintaining an active work life. Diagnosis and treatment require cooperation between different specialists and are based on multiple blood tests and other diagnostic tests. This article presents medical indications and the safety and efficacy of adalimumab, a tumor necrosis factor inhibitor and the first biological drug used in ophthalmology. Adalimumab is an important therapeutic option for the treatment of intermediate, posterior, and pan-uveitis, enabling patients to obtain and maintain long-term disease control during simultaneous corticosteroid/immunomodulatory therapy or without it.

Article Details

How to Cite
Kręcicka J, Turno-Kręcicka A, Misiuk-Hojło M. Adalimumab therapy of noninfectious uveitis. Ophthatherapy [Internet]. 2020Jun.30 [cited 2020Oct.21];7(2):90-5. Available from:
Conservative treatment


1. LaMattina KC, Goldstein DA. Adalimumab for the treatment of uveitis, Expert Rev Clin Immunol. 2017; 13(3): 181-8.
2. Sippy BD, Hofman FM, Wright AD et al. Soluble tumor necrosis factor receptors are present in human vitreous and shed by retinal pigment epithelial cells. Exp Eye Res. 1996; 63(3): 311-7.
3. Jaffe GJ, Dick AD, Brézin AP et al. Adalimumab in patients with active noninfectious uveitis. N Engl J Med. 2016; 375(10): 932-43.
4. Rudwaleit M, Rodevand E, Holck P et al. Adalimumab effectively reduces the rate of anterior uveitis flares in patients with active ankylosing spondylitis: results of a prospective open-label study. Ann Rheum Dis. 2009; 68(5): 696-701.
5. Van Denderen JC, Visman IM, Nurmohamed MT et al. Adalimumab significantly reduces the recurrence rate of anterior uveitis in patients with ankylosing spondylitis. J Rheumatol. 2014; 41(9): 1843-8.
6. Kim M, Won JY, Choi SY et al. Anti-TNF-α Treatment for HLA-B27-Positive Ankylosing Spondylitis-Related Uveitis. Am J Ophthal. 2016; 170: 32-40.
7. Bawazeer A, Raffa LH, Nizamuddin SH. Clinical experience with adalimumab in the treatment of ocular Behçet disease. Ocul Immunol Inflamm. 2010; 18(3): 226-32.
8. Fabiani C, Vitale A, Emmi G et al. Efficacy and safety of adalimumab in Behçet’s disease-related uveitis: a multicenter retrospective observational study. Clin Rheumatol. 2017; 36(1): 183-9.
9. Steeples LR, Spry P, Lee RWJ et al. Adalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy. International Ophthalmology. 2018; 38(3): 1357-62.
10. Hiyama T, Harada Y, Kiuchi Y. Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab. Am J Ophthalmol Case Rep. 2019; 14: 1-4.
11. Erckens RJ, Mostard RL, Wijnen PA et al. Adalimumab successful in sarcoidosis patients with refractory chronic non-infectious uveitis. Graefes Arch Clin Exp Ophthalmol. 2012; 250(5): 713-20.
12. Castiblanco C, Meese H, Foster CS. Treatment of pediatric uveitis with adalimumab: the MERSI experience. J Aapos. 2016; 20(2): 145-7.
13. Nguyen QD, Merrill PT, Jaffe GJ et al. Adalimumab for prevention of uveitic flare in patients with active non-infectious uveitis controlled by cortiocosteroids (VISUAL II): a multicenter, double-masked, randomized, placebo-controlled phase 3 trial. Lancet. 2016; 388: 1183-92.
14. Suhler EB, Adán A, Brézin AP et al. Safety and efficacy of adalimumab in patients with noninfectious uveitis in an ongoing open-label study: VISUAL III. Ophthalmology. 2018; 125: 1075-87.
15. Vallet H, Seve P, Biard L et al. Infliximab versus adalimumab in the treatment of refractory inflammatory uveitis: a multicenter study from the French uveitis network. Arthritis Rheumatol. 2016; 68: 1522-30.
16. Fabiani C, Vitale A, Rigante D et al. Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients. Clin Rheumatol. 2019; 38: 407-15.
17. Rosenbaum JT, Bodaghi B, Couto C et al. New observations and emerging ideas in diagnosis and management of non-infectious uveitis: A review. Semin Arthritis Rheum. 2019; 49(3): 438-45.
18. Załącznik B.105. Leczenie zapalenia błony naczyniowej oka (ZBN) – część pośrednia, odcinek tylny lub cała błona naczyniowa (ICD-10 H 20.0, H 30.0).

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.