The thyroid dysfunction during chronic amiodarone therapy – pathomechanism and therapeutic approach Review article

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Monika Józwowicz
Urszula Pogonowska
Marek Rosiak
Maria Kaźmierczuk
Dariusz A. Kosior

Abstract

Amiodarone is a III Class Vaughan Williams antiarrhythmic drug. It is used for treating atrial fibrillation, atrial flutter and ventricular tachycardia and for preventing recurrence of atrial fibrillation in patients with structural heart disease. Amiodarone has a high affinity for adipose tissue and consequently has long lasting pharmacological effects in chronic treatment. One amiodarone tablet contains much more iodine than the optimal daily intake, thus chronic treatment may results in thyroid function disorders. The mechanisms in which amiodarone influences thyroid function are complex and include inhibition of type 1deiodinase enzyme activity, blocking cardiac TRα1 receptor for triiodothyronine, iodine-induced excess thyroid hormone synthesis and release (type 1 amiodarone induced thyrotoxicosis), inhibiting iodide oxygenation resulting in decrease in hormones production causing amiodarone induced hypothyroidism, and finally direct cytotoxic activity resulting in type 2 amiodarone induced thyrotoxicosis. From clinical point of view amiodarone induced thyrotoxicosis is of much more importance than hypothyroidism and is a real therapeutic challenge. Treatment strategies include pharmacotherapy with thionamides, potassium perchlorate or steroids or radical treatment – thyroidectomy or radioiodine therapy. Prior treatment with amiodarone several laboratory tests should be performed. In order to monitor thyroid function and identify treatment complications in form of thyrotoxicosis of hypothyroidism, regular thyroid function assessment is recommended up to 2 years after treatment discontinuation.

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Józwowicz , M., Pogonowska , U., Rosiak , M., Kaźmierczuk , M., & Kosior , D. A. (2013). The thyroid dysfunction during chronic amiodarone therapy – pathomechanism and therapeutic approach. Cardiology in Practice, 7(4), 21-26. Retrieved from https://journalsmededu.pl/index.php/kwp/article/view/1551
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