New approach in management of vitreo-retinal interface disorders with ocriplasmine
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Published:
Mar 31, 2014
Keywords:
vitrea-retinal interence disorders, ocriplasmine, macular hole, vitreomacular traction syndrome
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Abstract
Symptomatic diseases of vitreo-retinal interface can result in traction and macular hole. Standard treatment for these disorders is pars plana vitrectomy. Ocriplasmine is a proteolytic enzyme that can cause resolution of the symptoms and replace surgical procedure in selected cases.
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Oficjalska J. New approach in management of vitreo-retinal interface disorders with ocriplasmine. Ophthatherapy [Internet]. 2014Mar.31 [cited 2024Nov.22];1(1):21-5. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/667
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References
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2. Gandorfer A. Objective of pharmacologic vitreolysis. Dev Ophthalmol. 2009; 44: 1-6.
3. Aerts F, Noppen B, Fonteyn . et al. Mechanism of inactivation of ocriplasmin in porcine vitreous. Biophys Chem. 2012; 165-166: 30-8.
4. Duker JS, Kaiser PK, Binder S et al. The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 2013; 120(12): 2611-9.
5. Stalmans P, Benz MS, Gandorfer A et al; MIVI-TRUST Study Group. Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med. 2012; 367(7): 606-15.
6. Geck U, Pustolla N, Baraki H et al. Posterior vitreous detachment following intravitreal drug injection. Graefes Arch Clin Exp Ophthalmol. 2013; 251(7): 1691-5.
7. Wong SC, Capone A Jr. Microplasmin (ocriplasmin) in pediatric vitreoretinal surgery: update and review. Retina. 2013; 33(2): 339-48.