Fungal keratitis
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Abstract
Fungal keratitis is a rare cause of corneal infection in moderate climate. The most frequent fungal pathogens are Aspergillus, then Fusarium and Penicillium. Fungi gain access into the corneal stroma through a defect in the epithelium, then multiply and cause tissue necrosis and an inflammatory reaction. The most important step in the initial management of suspected fungal keratitis before antifungal therapy is to obtain corneal material for laboratory investigations. The treatment is difficult, 30% of corneal fungal infections do not respond to pharmacological treatment and the corneal perforation can occur. A therapeutic full-thickness keratoplasty is essential in such situation. Surgery should be performed during the four weeks from first signs and symptoms of the disease.
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