Combined therapy of dry eye with hyaluronic acid
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Abstract
Aim of the study: presentation of benefits of a new lubricant formulation comprised of a dual polymer in the dry eye treatment.
Methods: review of literature on the impact on life and functional deficits in patients with dry eye disease. According to paper presented by Ketelson [14], there are special insights in pharmacodynamics of dual polymer lubrication drops.
Results: a demulcent solution of propylene glycol, polyethylene glycol, and the high-molecular weight polymer Hydroxypropyl guar (HPG) provides good viscoelastic properties, in optimal pH. Addition of sodium hyaluronate (HA) decreases the coefficient of friction, promotes lubrication and retention over ocular surface.
Conclusions: dual polymer HPG/HA formulation acts in potentially promoting desiccation protection, moisture retention, and improved surface lubricity on the ocular surface.
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Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
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