Treating wet form of AMD – pros and cons
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Published:
Mar 31, 2016
Keywords:
AMD, VEGF inhibitors
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Abstract
Anti-VEGF treatment is a gold standard in exudative AMD. Three drugs are currently used: ranibizumab (Lucentis), aflibercept (Eylea) and off- -label bevacizumab (Avastin). Different treatment regimen are used: fixed scheduled treatment, pro re nata and treat and extend.
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Święch-Zubilewicz A, Dolar-Szczasny J. Treating wet form of AMD – pros and cons. Ophthatherapy [Internet]. 2016Mar.31 [cited 2024May3];3(1):32-6. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/590
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References
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2. CATT Research Group, Martin DF, Maguire MG, Ying GS et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011; 364(20): 189.
3. Gupta OP, Shienbaum G, Patel AH et al. A treat and extend regimen using ranibizumab for neovascular age related macular degeneration clinical and economic impact. Ophthalmology. 2010; 117: 2134-40.
4. Holz FG, Amoaku W, Donate J et al. Safety and Efficacy of a Flexible Dosing Regimen of Ranibizumab in Neovascular Age-Related Macular Degeneration: The SUSTAIN Study. Ophthalmology. 2011; 118: 663-71.
5. Klein R, Klein BE, Tomany SC et al. Ten-year incidence of age-related maculopathy and smoking and drinking: The Beaver Dam Eye Study. Am J Epidemiol. 2002; 156: 589-98.
6. Lalwani GA, Rosenfeld PJ, Fung AE et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO Study. Am J Ophthalmol. 2009; 148(1): 43-58.
7. Larsen M, Schmidt-Erfurth U, Lanzetta P et al. Verterporfin plus Ranibizumab for Choroidal Neovascularisation in Age-Related Macular Degeneration. Twelve-month MONT BLANC Study Results. Ophthalmology. 2012; 119(5): 992-1000.
8. Martin DF, Maguire MG, Fine SL et al. Ranibizumab and bevacizumab for treatment of neovascular age related macular degeneration: two-year results. Ophthalmology. 2012; 119: 1388-98.
9. Muether PS, Hermann MM, Viebahn U et al. Vascular endothelial growth factor in patients with exudative age related macular degeneration treated with ranibizumab. Ophthalmology. 2012; 119: 2082-6.
10. Pascolini JD, Mariott SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012; 96(5): 614-8.
11. Richard G, Monés J, Wolf S et al. Scheduled versus Pro Re Nata Dosing in the VIEW Trials. Ophthalmology. 2015; 122: 2497-503.
12. Rosenfeld PJ, Brown DM, Heier JS et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006; 355: 1419-31.
13. Schmidt-Erfurth U, Kaiser PK, Korobelnik JF et al. Intravitreal aflibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies. Ophthalmology. 2014; 121: 192-201.
14. Wong TI, Li X, Su X et al. The Number and Distribution of People with Age-Related Macular Degeneration Worldwide. ARVO. 2013: 220-00065.
15. Wykoff CC, Croft DE, Brown DM et al. Prospective Trial of Treat-and Extend versus Monthly Dosing for Neovascular Age-Related Macular Degeneration. Ophthalmology. 2015; 122: 2514-22.