The impact of phosphates in eye drops on the ocular surface Review article

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Published: Jul 31, 2025
DOI: https://doi.org/10.24292/01.OT.230625
Keywords:
ocular surface, cornea, phosphate buffer, calcium phosphate deposits

Main Article Content

Dominika Wróbel-Dudzińska
Department of Diagnostic and Microsurgery of Glaucoma
https://orcid.org/0000-0002-1325-6692

Abstract

The ocular surface plays a key role in maintaining corneal transparency and protecting the visual organ from external factors. One of the threats to its integrity is the use of topical ophthalmic preparations containing phosphates, which – when the epithelium is damaged – can lead to the formation of calcium phosphate deposits and the development of band keratopathy. The aim of this article is to present the role of phosphates as excipients in eye drops, their mechanism of action, potential toxicity, and the risks associated with their long-term use. Special attention is given to the conditions that promote corneal calcification and the negative impact of phosphates on epithelial healing and regeneration processes. The article emphasizes the need to raise awareness among physicians and patients about the potential adverse effects of phosphates and the necessity for caution in their use, particularly in individuals with a compromised ocular surface.

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How to Cite
1.
Wróbel-Dudzińska D. The impact of phosphates in eye drops on the ocular surface. Ophthatherapy [Internet]. 2025Jul.31 [cited 2026Feb.22];12(2):136-40. Available from: https://journalsmededu.pl/index.php/ophthatherapy/article/view/3400
Issue
Vol 12 No 2 (2025)
Section
Conservative treatment

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