Corneal higher order aberrations in beta-thalassemia major Original research study
Article Sidebar
Main Article Content
Abstract
Purpose: This study aimed at evaluating the corneal higher order aberrations in beta-thalassemia major cases and comparing it to the healthy individuals.
Material and methods: It was a comparative cross-sectional study conducted on 56 beta-thalassemia major cases and 64 healthy controls from December 2023 to June 2024. All the participants received a standard ophthalmological examination subsequently followed by measurement of corneal higher order aberrations using Corneal Topography Galilei G5.
Results: The mean age of the cases and controls was comparable (P = 0.190). All the corneal higher order aberrations were significantly different among cases and controls (P <0.05), except for total coma, horizontal come, and spherical aberrations (P >0.05). Only fifth order aberrations were weakly positively correlated to thalassemia duration (r = 0.28, P = 0.033). The fourth order and spherical aberrations were weakly negatively correlated to hemoglobin levels (P = 0.029, P = 0.012 respectively). The fifth and sixth order aberrations were significantly different among the patients undergoing monotherapy and combined therapy (P = 0.006, P = 0.022 respectively).
Conclusions: Corneal higher order aberrations are greater in beta-thalassemia major cases potentially due to disease and its treatment-related factors. The findings of the study focuses the need for regular ocular monitoring in these patients to lessen potential visual disturbances and improve ocular health.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright: © Medical Education sp. z o.o. License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
2. Salman A, Ghabra M, Darwish TR et al. Corneal higher-order aberration changes after accelerated cross-linking for keratoconus. BMC Ophthalmol. 2022; 22(1): 225.
3. Salman A, Kailani O, Ghabra M et al. Corneal higher order aberrations by Sirius topography and their relation to different refractive errors. BMC Ophthalmol. 2023; 23(1): 104.
4. Kiuchi G, Hiraoka T, Ueno Y et al. Influence of refractive status and age on corneal higher-order aberration. Vision Res. 2021; 181: 32-7.
5. Li J, Xue C, Zhang Y et al. Diagnostic value of corneal higher-order aberrations in keratoconic eyes. Int Ophthalmol. 2023; 43(4): 1195-206.
6. Kandel S, Chaudhary M, Mishra SK et al. Evaluation of corneal topography, pachymetry and higher order aberrations for detecting subclinical keratoconus. Ophthalmic Physiol Opt J Br Coll Ophthalmic Opt Optom. 2022; 42(3): 594-608.
7. Wallerstein A, Gauvin M, Mimouni M et al. Keratoconus Features on Corneal Higher-Order Aberration Ablation Maps: Proof-of-Concept of a New Diagnostic Modality. Clin Ophthalmol Auckl NZ. 2021; 15: 623-33.
8. Erdinest N, London N, Landau D et al. Higher order aberrations in keratoconus . Int Ophthalmol. 2024; 44(1): 1-16.
9. Bolac R, Yildiz E, Balci S. Anterior Corneal High-order Aberrations in Fuchs’ Endothelial Corneal Dystrophy Classified by Scheimpflug Tomography. Optom Vis Sci. 2023; 100(2): 151.
10. Ning R, Huang X, Jin Y et al. Corneal Higher-Order Aberrations Measurements: Precision of SD-OCT/Placido Topography and Comparison with a Scheimpflug/Placido Topography in Eyes After Small-Incision Lenticule Extraction. Ophthalmol Ther. 2023; 12(3): 1595-610.
11. Zhou S, Chen X, Ortega-Usobiaga J et al. Characteristics and influencing factors of corneal higher-order aberrations in patients with cataract. BMC Ophthalmol. 2023; 23(1): 313.
12. Wu T, Wang Y, Li Y et al. The impact of corneal higher-order aberrations on dynamic visual acuity post cataract surgery. Front Neurosci. 2024; 18: 1321423.
13. Ortiz-Toquero S, Fernandez I, Martin R. Classification of Keratoconus Based on Anterior Corneal High-order Aberrations: A Cross-validation Study. Optom Vis Sci. 2020; 97(3): 169.
14. Koh S, Inoue R, Maeno S et al. Characteristics of Higher-Order Aberrations in Different Stages of Keratoconus. Eye Contact Lens. 2022; 48(6): 256.
15. Kohnen T, Mahmoud K, Bühren J. Comparison of Corneal Higher-Order Aberrations Induced by Myopic and Hyperopic LASIK. Ophthalmology. 2005; 112(10): 1692.e1-1692.e11.
16. Rudolph M, Laaser K, Bachmann BO et al. Corneal Higher-Order Aberrations after Descemet’s Membrane Endothelial Keratoplasty. Ophthalmology. 2012; 119(3): 528-35.
17. Shimizu E, Yamaguchi T, Yagi-Yaguchi Y et al. Corneal Higher-Order Aberrations in Infectious Keratitis. Am J Ophthalmol. 2017; 175: 148-58.
18. Yagi-Yaguchi Y, Yamaguchi T, Okuyama Y et al. Corneal Higher Order Aberrations in Granular, Lattice and Macular Corneal Dystrophies. PLOS ONE. 2016; 11(8): e0161075.
19. Bruzzese A, Martino EA, Mendicino F et al. Iron chelation therapy. Eur J Haematol. 2023; 110(5): 490-7.
20. Aksoy A, Aslan L, Aslankurt M et al. Retinal fiber layer thickness in children with thalessemia major and iron deficiency anemia. Semin Ophthalmol. 2014; 29(1): 22-6.
21. Haghpanah S, Zekavat OR, Safaei S et al. Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia. BMC Ophthalmol. 2022; 22: 279.
22. Uzun F, Karaca EE, Yıldız Yerlikaya G et al. Retinal nerve fiber layer thickness in children with β-thalassemia major. Saudi J Ophthalmol Off J Saudi Ophthalmol Soc. 2017; 31(4): 224-8.
23. Acer S, Balcı YI, Pekel G, Ongun TT et al. Retinal nerve fiber layer thickness and retinal vessel calibers in children with thalassemia minor. SAGE Open Med. 2016; 4: 2050312116661683.