Clinical evaluation of the effect of topical bevacizumab on morphology and function of filtering bleb with failure symptoms Original reaserch study

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Anna Kuna
Tomasz Żarnowski


Objectives: Evaluation of bevacizumab drops in patients undergoing trabeculectomy in order to inhibit postoperative wound healing.
Material and methods: A total of 53 patients treated surgically for glaucoma. The anti-glaucoma procedures with the creation of a filtering bleb were performed. The patients developed early postoperative bleb insufficiency qualifying them for the use of bevacizumab drops. Thirty were completely statistically analyzed; intraocular pressure and slit lamp examinations were performed and the bleb was assessed according to the MBGS. Additionally, photographs of the filtering blebs were made, which were used for bleb morphological analysis.
Results: Total success, after 6 months, without using anti-glaucoma drugs (intraocular pressure < 18 mmHg and a decrease in baseline intraocular pressure by 30%) was observed in 18 patients (60%). Partial success, after 6 months, without using anti-glaucoma drugs (decrease in baseline intraocular pressure by 30%) was achieved in 19 patients (63.3%).
Conclusions: Bevacizumab is an effective and safe adjunctive therapy with topical steroids for the treatment of early postoperative filtering bleb insufficiency as it reduces innervation on the bleb surface. Evaluation of the mean surface of bleb vessels on photographs, using ImageJ (Wayne Rasband), correlates with MBGS evaluation of filtering blebs.


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Kuna A, Żarnowski T. Clinical evaluation of the effect of topical bevacizumab on morphology and function of filtering bleb with failure symptoms. Ophthatherapy [Internet]. 2020Sep.30 [cited 2021Jul.25];7(3):203-12. Available from:
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