Could beta-blockers protect against progression of atherosclerosis? Review article
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Published:
Mar 31, 2008
Keywords:
beta-blockers, prevention, progression of atherosclerosis
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Abstract
Atherosclerosis is the most common cause of cardiovascular diseases. So far it has not been discovered how to slow down or to stop this process. In the light of current knowledge the authors try to explain the antiatherosclerotic effects of beta-blockers.
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Kuch , M., Światowiec , A., & Braksator , W. (2008). Could beta-blockers protect against progression of atherosclerosis?. Cardiology in Practice, 2(1), 30-37. Retrieved from https://journalsmededu.pl/index.php/kwp/article/view/1696
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References
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2. Gottlieb S.S., McCarter R.J., Vogel R.A. et al.: Effect of beta-blockade on mortality among high-risk and low risk patients after myocardial infarction. N.Engl.J.Med.1998, 339: 489-497.
3. López-Sendón J., Swedberg K., McMurray J. et al.: Expert consensus document on beta-adrenergic receptor blockers. Eur. Heart J. 2004, 25: 1341-62.
4. Gheorghiade M., Goldstein S.: Beta-blockers in the post-myocardial infarction patients. Circulation 2002, 106: 394-398.
5. Norwegian Timolol Trial Study Group: Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N. Engl. J. Med. 1981, 304: 801-807.
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9. ISIS-1 Collaborative Group: Randomized trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction. Lancet 1986, 2: 57-66.
10. Roberts R., Rogers W.J., Mueller H.S. et al.: Immediate versus differed beta blockade following thrombolytic therapy in patients with acute myocardial infraction. Results of the Thrombolysis in Myocardial Infarction (TIMI IIB). Circulation 1991, 83: 422-437.
11. Yusuf S., Lessen J., Pet J. et al.: Primary and secondary prevention of myocardial infarction and strokes: an update of randomly allocated controlled trials. J.Hypertens. 1993, 11(supl.4): S61-S73.
12. Freemantle N., Cleland J., Young P. et al.: Beta-blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 1999, 26: 1730-1737.
13. Beta-Blocker Pooling Project Research Group: Subgroup findings from randomized trials in post-myocardial infarction patients. Eur. Heart J. 1988, 9: 8-16.
14. Yusuf S., Wittes J., Friedman L.: Overview of results of randomized trials in heart disease: unstable angina, heart failure, primary prevention with aspirin and risk factors modification. JAMA 1988, 260: 2259-2263.
15. Bertrand M.E., Simoons M.L., Fox K.A. et al., Task Force on the Management of Acute Coronary Syndromes of the European Society of Cardiology: Management of acute coronary syndromes in patients presenting without persistent ST- segment elevation. Eur. Heart J. 2002, 23: 1809-1840.
16. Bristow M.R., Port J.D., Kelly R.A.: Treatment of heart failure: pharmacologic methods. W: Heart Disease: A Textbook of Cardiovascular Medicine, sixth edition. Braunwald E., Zippes D.P., Libby P. (red.). W.B. Saunders Company, Philadelphia 2001: 562-599.
17. Waagstein F.: Beta-blockers in congestive heart failure: the evolution of a new treatment concept-mechanism of action and clinical implications. J. Clin. Basic Cardiol. 2002, 5: 215-223.
18. Tamargo J.L., Delpon E.: Optimisation of β-blockers pharmacology. J. Cardiovasc. Pharmacol. 1990, 16(supl.5): S8-S10.
19. Frishman W.H.: Carvedilol. N. Engl. J. Med. 1998, 339: 1759-1765.
20. Rauls R.A., Tan Y., Knuepfer M.M.: Central beta-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress. Brain Res. 2005, 1048: 98-107.
21. Heidland U.E., Strauer B.E.: Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation 2001, 104: 1477-82.
22. Levy R.L., White P.D., Stroud W.D. et al.: Transient tachycardia: prognostic significance alone and in association with hypertension. J. Am. Med. Assoc.1945, 129: 585-588.
23. Jouven X., Desnos M., Guerot C., Ducimetiere P.: Predicting sudden death in population: the Paris Prospective Study I. Circulation 1999, 99: 1978-1983.
24. Greenland P., Daviglus M.L., Dyer A.R. et al.: Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality. Am. J. Epidemiol. 1999, 149: 853-862.
25. Palatini P., Casiglia S., Julius S., Pessina A.C.: Heart rate, a risk factor for cardiovascular mortality in elderly men. Arch. Int. Med. 1999, 159: 585-592.
26. Kaplan J.R., Manuck S.B.: Antiatherogenic effects of beta-adrenergic blocking agents: theoretical, experimental, and epidemiologic considerations. Am. Heart J.1994, 128: 1316-28.
27. ESC Committee for Practice Guidelines: Guidelines on the management of stable angina pectoris. Executive summary. The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. European Heart Journal 2006, 27: 1341-1381.
28. Pasterkamp G., Falk E., Woltman H., Borst C.: Techniques characterizing the coronary atherosclerotic plaque: influence on clinical decision making? J. Am. Coll. Cardiol. 2000, 36: 13-21.
29. Iglesias del Sol A., Bots M.L., Grobbee D.E. et al.: Carotid intima – media thickness at different sites: relation to incident myocardial infarction. The Rotterdam Study. Eur. Heart J. 2002, 23: 934-940.
30. Drechsler D., Kornacewicz-Jach Z.: Assessment of carotid arteries and pulse wave velocity in patients with three-vessel coronary artery disease. Kardiol. Pol. 2002, 57: 193-197.
31. Hedblad B., Wikstrand J., Janzon L. et al.: Low dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation 2001, 103: 1721-1726.
32. Wiklund O., Hulthe J., Wikstrand J. et al.: Effect of controlled release/extended release metoprolol on carotid intima-media thickness in patients with hypercholesterolemia: a 3-year randomized study. Stroke 2002, 33: 572-577.
33. Sipahi I., Tuzcu E.M., Wolski K.E. et al.: Beta-blockers and progression of coronary atherosclerosis: pooled analysis of 4 intravascular ultrasonography trials. Ann. Intern. Med. 2007, 147: 10-18.
34. Dunn C.J., Lea A.P., Wagstaff H.: Carvedilol: a reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs 1997, 54: 161-185.
35. Ohtsuka T., Hamada M., Saeki H. et al.: Serum levels of matrix metalloproteinases and tumor necrosis factor in patients with idiopathic dilated cardiomyopathy and effects of carvedilol on these levels. Am. J. Cardiol. 2002, 91: 1024-1027.
36. Rossig L., Haendeler J., Mallat Z. et al.: Congestive heart failure induces cell apoptosis: protective role of carvedilol. JACC 2000, 36: 2081-2089.
37. Gage J.R., Fonarow G., Hamilton M. et al.: Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation 2004, 11: 173-80.
38. Mayer B., Holmer S.R., Hengstenberg C. et al.: Functional improvement in heart failure patients treated with beta-blockers is associated with a decline of cytokine levels. Int. J. Cardiol. 2005, 103: 182-186.
39. Matsumura T., Tsushima K., Ohtaki E. et al.: Effects of carvedilol on plasma levels of interleukin-6 and tumor necrosis factor-alpha in nine patients with dilated cardiomyopathy. J. Cardiol. 2002, 39: 253-257.
40. Tsutamoto T., Wada A., Matsumoto T. et al.: Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. 2001, 37: 2086-92.
41. Yuan Z., Shioji K., Kihara Y. et al.: Cardioprotective effects of carvedilol on acute autoimmune myocarditis anti-inflammatory effects associated with antioxidant property. Am. J. Physiol. Heart Circ. Physiol. 2004, 286: H83-H90.
42. Prabhu S.D., Chandrasekar B., Murray D.R. et al.: Beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation 2000, 101: 2072-9. [Errata w: Circulation 2000, 102: 141].
43. Falciani M., Rinaldi B., D’Agostino B. et al.: Effects of nebivolol on human platelet aggregation. J. Cardiovasc. Pharmacol. 2001, 38: 922-929.
44. Vyssoulis G.P., Marinakis A.G., Aznaouridis K.A. et al.: The impact of third-generation beta-blocker antihypertensive treatment on endothelial function and the prothrombotic state: effects of smoking. Am. J. Hypertens. 2004, 17: 582-9.
45. Mallamaci F., Tripepi G., Maas R. et al.: Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease. J. Am. Soc. Nephrol. 2004, 15: 435-441.
46. Feuerstein G.Z., Ruffolo R.R. Jr.: Carvedilol, a novel vasodilating beta-blocker with the potential for cardiovascular organ protection. Eur. Heart J. 1996, 17(supl. B): 24-9.
47. Chłopicki S., Kozlovski V.I., Gryglewski R.J.J.: NO-dependent vasodilatation induced by nebivolol in coronary circulation is not mediated by beta-adrenoreceptors or by 5HT-1A receptors. Physiol. Pharmacol. 2002, 53: 615-624.
48. Mollnau H., Schulz E., Daiber A. et al.: Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. Arterioscler. Thromb. Vasc. Biol. 2003, 23: 615-621.
49. Ignarro L.J.: Experimental evidences of nitric oxide-dependent vasodilatatory activity of nebivolol, a third generation beta-blocker. Blood Pressure 2004, 13(S1): 3-17.
50. Cominacini L., Pasini A.F., Garbin U. et al.: Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. JACC 2003, 42: 1838-1844.
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