Are there non-steroidal anti-inflammatory drugs safe for the heart? Practical implications from PRECISION Trial Review article
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Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) are associated with increased cardiovascular risk and significant differences between various molecules were suggested. The PRECISION trial was designed to compare safety of celecoxib with non-selective NSAIDs (naproxen and ibuprofen) in a group of subjects with high cardiovascular risk and rheumatoid arthritis or osteoarthritis. The PRECISION trial showed the noninferiority of moderate doses of celecoxib, as compared with naproxen or ibuprofen, with regard to the primary cardiovascular outcome. Celecoxib treatment also resulted in lower rates of gastrointestinal events than did either comparator drug and in lower rates of renal adverse events than did ibuprofen. The data from PRECISION trial did not confirm the notion on differences in cardiovascular safety of certain NSAIDs.
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