10 reasons, why it is worth to take vitamin D Review article
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Abstract
Vitamin D is a group of fat-soluble vitamins. The best known function of vitamin D is influence on intestinal calcium and phosphorus absorption. Together with PTH and calcitonin vitamin D regulates bone metabolism and maintains constant serum calcium concentration. Vitamin D was discovered more than 100 years ago, however only in 30s of the last century rickets was associated with its deficiency. Research from the second half of the 20th century have shown that vitamin D is actually a prohormone, which only after connection to specific receptor (VDR) and transformation, manifests its activity. In recent years there has been a huge increase in interest in pleiotropic action of vitamin D. The important role of vitamin D deficiency as a risk factor, not only of rickets and osteomalacia, but also of cardiovascular diseases, autoimmunology, infections, cancer, diabetes and depression have been suggested in numerous studies. In the light of these studies vitamin D supplementation seems reasonable, especially in the autumn-winter period.
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