Profile of the patient effectively treated with fixed-dose, triple-combination ternary preparation – hypertensiologist’s point of view Case report
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Abstract
An obese patient with poorly controlled hypertension was presented in article. Based on patients’ examinations and additional studies his cardiovascular risk was estimated. Fixed-dose, triple-combination drug was introduced in patients treatment, after earlier therapeutic modifications. Satisfactory blood pressure control has been achieved. Based on this case, a principles of hypotensive therapy were presented including benefits followed the use of fixed-dose combination drugs. The reasons of using of perindopril, amlodipine and indapamide were also discussed.
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References
2. Conlin P.R., Gerth W.C., Fox J. et al.: Persistence to antihypertensive drug classes throughout four years. Clin. Ther. 2001; 23: 1999-2010.
3. Dahlöf B., Sever P.S., Poulter N.R. et al.; ASCOT Investigators: Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet 2005; 366: 895-906.
4. Dezii CM.: A retrospective study of persistence with single pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Management Care 2000; 9: 2-6.
5. Hansson L., Zanchetti A., Carruthers S.G. et al.: Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial. Lancet 1998, 351: 1755-1762.
6. Jamerson K., Weber M.A., Bakris G.L. et al.; ACCOMPLISH Trial Investigators: Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N. Engl. J. Med. 2008; 359: 2417-2428.
7. Pall D., Szanto I., Szabo Z.: Triple combination therapy in hypertension: the antihypertensive efficacy of treatment with perindopril, amlodipine, and indapamide SR. Clin. Drug Investig. 2014; 34: 701-708.
8. Troth K.; PIANIST Investigators: Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hypertensive patients). Am. J. Cardiovasc. Drugs 2014; 14: 137-145.
9. Tykarski A., Narkiewicz K., Gaciong Z. et al.: Zasady postępowania w nadciśnieniu tętniczym – 2015 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze w Praktyce 2015; 1: 1-70.
10. Widecka K., Grodzicki T., Narkiewicz K. et al.: Zasady postępowania w nadciśnieniu tętniczym – 2011 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze 2011; 15: 55-82.
11. Wytyczne ESH/ESC dotyczące postępowania w nadciśnieniu tętniczym w 2013 roku. Nadciśnienie Tętnicze 2013; 17(2): 69-168.