The role of nebivolol in men with hypertension and erectile dysfunction – experience of Ostróda center Case report

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Published: Jul 11, 2018
Keywords:
nebivolol, arterial hypertension, erectile dysfunction

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Radosław Grabysa
Oddział Chorób Wewnętrznych o Profilu Kardiologicznym, Centrum Zdrowia Medica S.A.

Abstract

Nebivolol is a highly cardioselective β-blocker of the 3rd generation with vasodilating properties. Its unique characteristics include, among others, increasing the production of nitric oxide in the vascular endothelium, which minimizes the risk of sexual dysfunction observing during therapy with classical β-blockers. This paper presents clinical cases illustrating the place of nebivolol in the treatment of arterial hypertension and comorbidities among men with erectile dysfunction.

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How to Cite
Grabysa , R. (2018). The role of nebivolol in men with hypertension and erectile dysfunction – experience of Ostróda center. Cardiology in Practice, 12(2), 3-10. Retrieved from https://journalsmededu.pl/index.php/kwp/article/view/1213
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Vol 12 No 2 (2018)
Section
Articles
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References

1. Braunwald E.: Cardiovascular pharmacology: a look back and a glimpse into the future. Eur. Heart J. Cardiovasc. Pharmacother. 2015; 1: 7-9.
2. Tykarski A., Narkiewicz K., Gaciong Z. et al.: Zasady postępowania w nadciśnieniu tętniczym – 2015 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze w Praktyce 2015; 1: 1–70.
3. Klocek M., Rajzer M., Kawecka-Jaszcz K.: Występowanie zaburzeń wzwodu u mężczyzn z pierwotnym nadciśnieniem tętniczym. Nadciśnienie Tętnicze 2003; 7: 181-189.
4. Ko D.T., Hebert P.R., Coffey C.S. et al.: Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 2002; 288: 351-357.
5. Filipiak K.J., Puchalski B.: Wpływ leków na sprawność seksualną. Interakcje leków w praktyce terapii dysfunkcji seksualnej. W: Kardioseksuologia. Medical Education, Warszawa 2011.
6. Silvestri A., Galetta P., Cerquetani E. et al.: Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. Eur. Heart J. 2003; 24: 198-1932.
7. Münzel T., Gori T.: Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J. Am. Coll. Cardiol. 2009; 54: 1491-1499.
8. Van Nueten L., De Cree J.: Nebivolol: comparison of the effects of dl-nebivolol, d-nebivolol, l-nebivolol, atenolol, and placebo on exercise-induced increases in heart rate and systolic blood pressure. Cardiovasc. Drugs Ther. 1998; 12(4): 339-344.
9. Sorrentino S.A., Doerries C., Manes C. et al.: Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional beta1-blockade. J. Am. Coll. Cardiol. 2011; 57(5): 601-611.
10. Studinger P., Tabak A.G., Chen C.H. et al.: The effect of low-dose carvedilol, nebivolol, and metoprolol on central arterial pressure and its determinants: a randomized clinical trial. J. Clin. Hypertens. 2013; 15(12): 910-917.
11. Toblli J.E., DiGennaro F., Giani J.F. et al.: Nebivolol: impact on cardiac and endothelial function and clinical utility. Vasc. Health Risk Manag. 2012; 8: 151-160.
12. Birenbaum A., Tesse A., Loyer X. et al.: Involvement of beta-3-adrenoreceptor in altered beta-adrenergic response in senescent heart: role of nitric oxide synthase 1-derived nitric oxide. Anaesthesiology 2008; 109(6): 1045-1053.
13. Brixius K., Middeke M., Lichtenthal A. et al.: Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clin. Exp. Pharmacol. Physiol. 2007; 34: 327-331.
14. Doumas M., Tsakiris A., Douma S. et al.: Beneficial effects of switching from beta-blockers to nebivolol on the erectile function in hypertensive patients. Asian J. Androl. 2006; 8: 177-182.
15. Boydak B., Nalbantgil S., Fici F. et al.: A Randomised Comparison of the Effects of Nebivolol and Atenolol with and without Chlorthalidone on the Sexual Function of Hypertensive Men. Clin. Drug Investig. 2005; 25: 409-416.