Gene polymorphisms related to an increased incidence of arterial hypertension in a cohort of Polish patients with obstructive sleep apnea syndrome (OSAS) Original article

Article Sidebar

Requires Subscription PDF


Published: Dec 31, 2018
Keywords:
obstructive sleep apnoea, arterial hypertension, genetic factors

Main Article Content

Piotr Bielicki
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland
Robert Pływaczewski
II Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases Warsaw, Poland
Kamil Brzóska
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
Piotr Sobieraj
Department of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Poland
Małgorzata Barnaś
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland
Marta Kumor
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland
Luiza Jonczak
II Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases Warsaw, Poland
Tomasz M. Stępkowski
Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland
Aleksandra Piechuta
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland
Ryszarda Chazan
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland
Paweł Śliwiński
II Department of Respiratory Medicine, Institute for Tuberculosis and Lung Diseases Warsaw, Poland
Marcin Kruszewski
1. Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, Poland. 2. Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland

Abstract

Introduction: Obstructive sleep apnoea (OSA) in an independent risk factor for arterial hypertension development. Both OSA and arterial hypertension frequently coexist, thus common genetic background can be suspected.


Material and methods: We enrolled 600 participants with diagnosis of OSA in all stages of severity from 2 tertiary care outpatient clinics in Warsaw, Poland. All patients undergone polysomnography and were evaluated for the diagnosis of hypertension. Gene polymorphisms for genes encoding ALOX5AP, SREBF2, ADRA2A, APOA5 and TCF7L2 were analyzed in blood samples. Chisquare and Mann-Whitney tests were used for comparisons.


Results: Data of 449 (74.8%) men and 151 (25.2%) women were analyzed. Arterial hypertension was diagnosed in 427 (71.2%) participants. In the hypertensive patients with OSA median age was 59 (53–64) years, BMI 32.8 (28.9– 37.3) kg/m2, AHI 39 (24–60)/hour. Among tested genes only TCF7L2 polymorphism ([C/T] rs7903146) was linked to increased incidence of arterial hypertension.


Conclusions: Results of our analysis suggest potential relationship of TCF7L2 polymorphism ([C/T] rs7903146) and development of hypertension in patients with OSA, although further studies regarding impact of genetic in comparison with traditional risk factor for hypertension are needed.

Downloads

Download data is not yet available.

Article Details

How to Cite
Bielicki , P., Pływaczewski , R., Brzóska , K., Sobieraj , P., Barnaś , M., Kumor , M., Jonczak , L., Stępkowski , T. M., Piechuta , A., Chazan , R., Śliwiński , P., & Kruszewski , M. (2018). Gene polymorphisms related to an increased incidence of arterial hypertension in a cohort of Polish patients with obstructive sleep apnea syndrome (OSAS) . Cardiology in Practice, 12(3-4), 21-27. Retrieved from https://journalsmededu.pl/index.php/kwp/article/view/1208
Issue
Vol 12 No 3-4 (2018)
Section
Medical evidence in cardiology
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

References

1. Pływaczewski R, Bednarek M, Jończak L et al. Sleep disordered breathing in middle-aged and older Polish urban population. J Sleep Res 2008; 17: 73-81.
2. Phillips B. Sleep-disordered breathing and cardiovascular disease. Sleep Med Rev 2005; 9: 131-140.
3. Robinson GV, Stradling JR, Davies RJ. Sleep. 6: obstructive sleep apnoea/hypopnoea syndrome and hypertension. Thorax 2004; 59: 1089-1094.
4. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet 2002; 359 (9302): 204-210.
5. Riha RL, Brander P, Vennelle M et al. Tumor necrosis factor-alpha (-308) gene polymorphism in obstructive sleep apnoea-hypopnoea syndrome. Eur Respir J 2005; 26: 673-678.
6. Bhushan B, Guleria R, Misra A et al. TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea. Respir Med 2009; 103: 386-392.
7. Bayazit YA, Yilmaz M, Erdal E et al. Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol 2009; 266: 449-454.
8. Lavie L, Lotan R, Hochberg I et al. Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome. Sleep 2003; 26: 592-595.
9. Liu HG, Liu K, Zhou YN et al. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. Chin Med J 2009; 122: 1369-1374.
10. Lõhmussaar E, Gschwendtner A, Mueller JC et al. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 2005; 36: 731-736.
11. Fan YM, Karhunen PJ, Levula M et al. Expression of sterol regulatory element-binding transcription factor (SREBF)2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death. Thromb J 2008; 6: 17. http:/doi.org/10.1186/1477-9560-6-17.
12. Lima JJ, Feng H, Duckworth L et al. Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metabolism 2007; 56(6): 757-765.
13. Laurila PP, Naukkarinen J, Kristiansson K et al. Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis. Arterioscler Thromb Vasc Biol 2010; 30: 346-352.
14. Lyssenko V, Lupi R, Marchetti P et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007; 117(8): 2155-2163.
15. Iber C, Ancoli-Israel S, Chesson AL, Jr, Quan SF. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. American Academy of Sleep Medicine 2007.
16. Haas DC, Foster GL, Nieto FJ et al. Age-dependent associations between sleep – disordered breathing and hypertension. Circulation 2005; 111: 614-621.
17. Planes C, Leroy M, Fayet G et al. Exacerbation of sleep-apnea related nocturnal blood pressure fluctuations in hypertensive subjects. Eur Respir J 2002; 20: 151-157.
18. Rahmouni K, Correia ML, Haynes WG et al. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2004; 45: 9-14.
19. Grant SF. Understanding the elusive mechanism of action of TCF7L2 in metabolism. Diabetes 2012; 61(11): 2657-2658.