The effect of caffeine contained in energy drink on selected parameters of central blood pressure Original article
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Abstract
Introduction: The popularity of energy drink consumption shows a steady upward trend among people around the world. Excessive intake of caffeine contained in food products is associated with an increase in the risk of cardiovascular issues. One of the potential pathomechanisms involved in this process is the effect of caffeine on the central blood pressure.
Purpose of work: The aim of the work was to evaluate the effects of caffeine contained in the popular energy drink on the heart rate and the central pressure values in young adults.
Material and methods: 20 healthy subjects aged 18–30 years old (9 men), who were randomised to the study, who had selected haemodynamic parameters before and after ingestion of 500 ml of an energy drink (NE) containing 150 mg of caffeine or 500 ml of an aromatic and non-caffeine beverage containing flavours (NN). Two studies with different drinks were carried out in each of the volunteers, and the allocation of fluid was made in the blinded and random manner. The study looked at systolic peripheral and central blood pressure (pSBP, cSBP), diastolic peripheral and central blood pressure (pDBP, cDBP), central pressure amplification factor (Aix), and heart rate (HR).
Results: Between 60 and 180 minutes of study time, higher values of pSBP and cSBP were found in the NE group as compared to NN group (123.9 ± 13.4 vs. 120.3 ± 13.8 mmHg, p < 0.001; 112.7 ± 10.9 vs. 109.8 ± 11.1, p = < 0.001) and pDBP and cDBP (79.3 ± 7.6 vs. 76.3 ± 7.7 mmHg, p < 0.001; 81.1 ± 7.8 vs. 77.8 ± 7.8 mmHg, p < 0.001). There were no differences in Aix values (15.6 ± 12.6 vs. 14.4 ± 11.2, p = 0.161), and heart rate (69.6 ± 10.7 vs. 70.9 ± 11.7/min, p = 0.05).
Conclusion: The negative effects of caffeine on the circulatory system may result from the increase in central pressure which more than the peripheral pressure increases the follow-up load of the left ventricle. However, there were no differences in the gain factor that better than the blood pressure values correlate with mortality in the different patient
groups.
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Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
2. Wright G.A., Baker D.D., Palmer M.J. et al.: Caffeine in floral nectar enhances a pollinator’s memory of reward. Science 2013; 339(6124): 1202-1204.
3. Fredholm B.B., Battig K., Holmen J. et al.: Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol. Rev. 1999; 51(1): 83-133.
4. Barone J.J., Roberts H.R.: Caffeine consumption. Food Chem. Toxicol. 1996; 34(1): 119-129.
5. Mitchell D.C., Hockenberry J., Teplansky R. et al.: Assessing dietary exposure to caffeine from beverages in the U.S. population using brand-specific versus category-specific caffeine values. Food Chem. Toxicol. 2015; 80: 247-252.
6. Cichocki M.: Napoje energetyzujące – współczesne zagrożenie zdrowotne dzieci i młodzieży. Prz. Lek. 2012; 69(10): 854-860.
7. Mitchell D.C., Knight C.A., Hockenberry J. et al.: Beverage caffeine intakes in the U.S. Food Chem. Toxicol. 2014; 63: 136-142.
8. Fulgoni V.L., Keast D.R., Lieberman H.R.: Trends in intake and sources of caffeine in the diets of US adults: 2001-2010. Am. J. Clin. Nutr. 2015; 101(5): 1081-1087.
9. Basrai M., Schweinlin A., Menzel J. et al.: Energy drinks induce acute cardiovascular and metabolic changes pointing to potential risks for young adults: a randomized controlled trial. J. Nutr. 2019; 149(3): 441-450.
10. Blanchard J., Sawers S.J.: The absolute bioavailability of caffeine in man. Eur. J. Clin. Pharmacol. 1983; 24: 93-98.
11. Cornish H.H., Christman A.A.: A study of the metabolism of theobromine, theophylline, and caffeine in man. J. Biol. Chem. 1957; 228: 315-323.
12. Barnes P.J.: Pulmonary pharmacology. Section on methylxanthines. In: Brunton L.L., Chabner B.A., Knollmann B.C. (ed): Goodman & Gilman’s The Pharmacological Basis of Therapeutics. McGraw-Hill, New York 2011.
13. Miles-Chan J.L., Charrière N., Grasser E.K. et al.: The blood pressure-elevating effect of Red Bull energy drink is mimicked by caffeine but through different hemodynamic pathways. Physiol. Rep. 2005; 3: e12290.
14. Berger A.J., Alford K.: Cardiac arrest in a young man following excess consumption of caffeinated “energy drinks“. Med. J. Aust. 2009; 190: 41-43.
15. Torbey E., Abi Rafeh N., Khoueiry G. et al.: Ginseng: a potential cause of long QT. J. Electrocardiol. 2011; 44: 357-358.
16. Jonjev Z.S., Bala G.: High-energy drinks may provoke aortic dissection. Coll. Antropol. 2013; 37: 227-229.
17. Rottlaender D., Motloch L.J., Reda S. et al.: Cardiac arrest due to long QT syndrome associated with excessive consumption of energy drinks. Int. J. Cardiol. 2012; 158: e51-52.
18. Kaoukis A., Panagopoulou V., Mojibian H.R. et al.: Reverse Takotsubo cardiomyopathy associated with the consumption of an energy drink. Circulation 2012; 125: 1584-1585.
19. Benjo A.M., Pineda A.M., Nascimento F.O. et al.: Left main coronary artery acute thrombosis related to energy drink intake. Circulation 2012; 125: 1447-1448.
20. Karatzis E., Papaioannou T.G., Aznaouridis K. et al.: Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure? Int. J. Cardiol. 2005; 98(3): 425-430.
21. McEniery C.M., Cockcroft J.R., Roman M.J. et al.: Central blood pressure: current evidence and clinical importance. Eur. Heart J. 2014; 35(26): 1719-1725.
22. Svatikova A., Covassin N., Somers K.: Cardiovascular response to energy drink consumption in healthy adults. Circulation 2014; 130: A18257.
23. Papaioannou T.G., Karatzi K., Karatzis E. et al.: Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressure. Am. J. Hypertens. 2005; 18(1): 129-136.
24. Basrai M., Schweinlin A., Menzel J. et al.: Energy drinks induce acute cardiovascular and metabolic changes pointing to potential risks for young adults: a randomized controlled trial. J. Nutr. 2019; 149(3): 441-450.
25. Waldron M., Patterson S.D., Tallent J.: The effect of oral taurine on resting blood pressure in humans: a meta-analysis. Curr. Hypertens. Rep. 2018; 20(9): 81.