Metoprolol as a universal β-blocker: sample clinical scenarios Case reports

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Michał Grabysa
Agata Tomaszewska
Radosław Grabysa

Abstract

Metoprolol, a highly cardioselective beta-blocker without intrinsic sympathomimetic activity, continues to play an important role in current treatment guidelines for hypertension, chronic heart failure, and coronary artery disease. Experts pay special attention to its modern, slow-release pharmaceutical form in the form of succinate, thoroughly tested in a number of clinical trials. Metoprolol succinate can be used in a single daily dose which ensures high compliance. The paper presents typical clinical scenarios in which appropriately dosed metoprolol CR/XL should be used. It should be emphasized that metoprolol CR/XL has the most registration indications among all the original β-blockers.

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How to Cite
Grabysa , M., Tomaszewska , A., & Grabysa , R. (2020). Metoprolol as a universal β-blocker: sample clinical scenarios. Cardiology in Practice, 14(3-4), 26-33. Retrieved from https://journalsmededu.pl/index.php/kwp/article/view/1165
Section
Clinical pharmacology in practice

References

1. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018; 392(10159): 1736-88.
2. Braunwald E. Cardiovascular pharmacology: a look back and a glimpse into the future. Eur Heart J Cardiovasc. Pharmacother. 2015; 1: 7-9.
3. Dąbrowski R. Antagoniści układu adrenergicznego. In: Kardiologia. Podręcznik Polskiego Towarzystwa Kardiologicznego. Via Medica, Gdańsk 2019.
4. Williams B, Mancia G, Desormais I et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. J Hypertens. 2018; 36: 1953-2041.
5. Tykarski A, Filipiak KJ, Januszewicz A et al. Zasady postępowania w nadciśnieniu tętniczym – 2019 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze w Praktyce. 2019; 5(1): 1-86.
6. Ponikowski P, Voors A, Anker S et al. Wytyczne ESC dotyczące diagnostyki i leczenia ostrej i przewlekłej niewydolności serca w 2016 roku. Kardiol Pol. 2016; 74(10): 1037-147.
7. Montalescot G, Sechtem U, Achenbach S et al. Wytyczne ESC dotyczące postępowania w stabilnej chorobie wieńcowej w 2013 roku. Kardiol Pol. 2013; 71(suppl X): 243-318.
8. Charakterystyka produktu leczniczego Betaloc ZOK, 02.2017.
9. Hjalmarson A, Goldstein S, Fagerberg B et al. MERIT-HF Study Group: Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive Heart Failure (MER-IT-HF). JAMA. 2000; 283: 1295-130.
10. Fonarow GC, Abraham WT, Albert NM et al. Dosing of Beta-Blocker Therapy Before, During, and After Hospitalization for Heart Failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure). Am J Cardiol. 2008; 102: 1524-9.
11. Bhatt AS, DeVore AD, DeWald TA et al. Achieving a Maximally Tolerated b-Blocker Dose in Heart Failure Patients Is There Room for Improvement? J Am Coll Cardiol. 2017; 69(20): 2542-50.
12. Filipiak KJ, Opolski G. Działania niepożądane i środki ostrożności przy stosowaniu leków beta-adrenolitycznych – spojrzenie z perspektywy 2005 roku. Choroby Serca i Naczyń. 2005; 2(3): 157-16.
13. Wikstrand J, Wedel H, Castagno D et al. The large-scale placebo-controlled beta-blocker studies in systolic heart failure revisited: results from CIBIS-II, COPERNICUS and SENIORS-SHF compared with stratified subsets from MERIT-HF. J Intern Med. 2014; 275: 134-43.
14. Ruwald AC, Gislason GH, Vinther M et al. Importance of beta-blocker dose in prevention of ventricular tachyaarythmias, heart failure hospitalizations, and death in primary prevention implantable cardioverter-defibrillator recipients: a Danish nationwide cohort study. Europace. 2018; 20: f217-24.
15. Van Veldhuisen DJ, Aass H, El Allaf D et al. Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MER-IT-HF Study. Eur J Heart Fail. 2006; 8: 539-54.
16. Kühlkamp V, Schirdewan A, Stangl K et al. Use of metoprolol CR/XL to maintain sinus rhythm after conversion from persistent atrial fibrillation: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol. 2000; 36(1): 139-46.