OphthaTherapy. Terapie w okulistyce https://journalsmededu.pl/index.php/ophthatherapy <p>"OphthaTherapy. Therapies in Ophthalmology" (abbr.: OphthaTherapy) is a peer-reviewed scientific quarterly publishing papers in: ophthalmology, ophthalmic surgery (including minimally invasive surgery and laser therapy), pharmacological treatment of eye diseases, including glaucoma, as well as work in the contactology. The journal is on the list of the Polish Ministry of Science and Higher Education. For publishing the article, the author receives 20 points.<br>We encourage you to submit: original papers, review articles, case reports, rapid communication, research letters, hypotheses, meeting proceedings, letter to the editor. We guarantee fast publication. There are no submission or processing charges.<br><br><strong><span lang="en-GB">e-ISSN: </span></strong><span lang="en-GB">2543-9987</span><span lang="en-GB">&nbsp;</span><strong><span lang="en-GB"> &nbsp; &nbsp; &nbsp;ISSN: 2353-7175 &nbsp; &nbsp; &nbsp; DOI: </span></strong><span lang="en-GB">10.24292/01.OT<br><br></span><strong><span lang="en-GB">Indexed in:&nbsp;</span></strong><span lang="en-GB">Polish Ministry of Science and Higher Education Journals Master List: 20 points&nbsp;<br></span><span lang="en-GB">&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Google Scholar<br></span>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Polish Scientific Journal Database</p> Medical Education sp. z o.o. en-US OphthaTherapy. Terapie w okulistyce 2353-7175 <p><strong>Copyright: © Medical Education sp. z o.o.</strong> License allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</p> <p><em>Address reprint requests to: Medical Education, Marcin Kuźma (<a href="mailto:marcin.kuzma@mededu.pl">marcin.kuzma@mededu.pl</a>)</em></p> Flaremetric evaluation of blood-aqueous barrier breakdown in diabetic patients after phacoemulsification and intraocular lenses with or without heparin-coated surface implantation https://journalsmededu.pl/index.php/ophthatherapy/article/view/1034 <p><strong>Background</strong>: This study compared the intensity of blood-aqueous barrier breakdown in diabetic patients after phacoemulsification with heparin surface-modified and non-modified intraocular lens (IOL) implantation.</p> <p><strong>Material and methods</strong>: In this prospective trial, 68 diabetic patients were enrolled and divided into two groups: 33 patients with heparin surface-modified IOL implants (group 1) and 35 patients with standard hydrophobic IOL implants (group 2). Blood-aqueous barrier breakdown was assessed using a Laser Flare Meter 1 day, 7 days, 14 days, 1 month, and 3 months postoperatively.</p> <p><strong>Results</strong>: On postoperative days 1 and 7, the mean flare value was significantly higher in group 2 compared with group 1. On day 14, the mean flare value in both groups was similar and then higher in group 2.</p> <p><strong>Conclusions</strong>: The implantation of foldable heparin-coated IOLs led to a lower intensity and faster recovery of blood-aqueous barrier breakdown postoperatively.</p> Anna Górnik Piotr Jurowski Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-05-23 2020-05-23 7 2 85 89 10.24292/01.OT.230520 Adalimumab therapy of noninfectious uveitis https://journalsmededu.pl/index.php/ophthatherapy/article/view/1035 <p>Noninfectious uveitis is known for its chronic and cumulative nature. It is often associated with diagnostic and therapeutic difficulties. It causes significant vision loss in young patients, making them incapable of maintaining an active work life. Diagnosis and treatment require cooperation between different specialists and are based on multiple blood tests and other diagnostic tests. This article presents medical indications and the safety and efficacy of adalimumab, a tumor necrosis factor inhibitor and the first biological drug used in ophthalmology. Adalimumab is an important therapeutic option for the treatment of intermediate, posterior, and pan-uveitis, enabling patients to obtain and maintain long-term disease control during simultaneous corticosteroid/immunomodulatory therapy or without it.</p> Julia Kręcicka Anna Turno-Kręcicka Marta Misiuk-Hojło Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 90 95 10.24292/01.OT.300620.1 Zoonoses in ophthalmology: Part III. Changes in the course of Lyme disease https://journalsmededu.pl/index.php/ophthatherapy/article/view/1036 <p>Borreliosis is a disease that was discovered in the 1970s, but its pathophysiological mechanisms and clinical course are not yet fully understood. The number of diagnosed Lyme disease cases in Poland has been increasing over the last decade. Poland has seen endemic Lyme disease, with one of the highest rates of infection in Europe. It is a zoonotic, vector-related disease that is transmitted by ticks that are infected with <em>Borrelia burgdorferi</em> spirochetes. One of the least known, poorly documented, and rarely recognized forms of Lyme disease is ocular borreliosis. Ocular alterations can occur in both the anterior and posterior segments of the eye, depending on the phase of the disease. In early stages when the tick bite is close to the eyeball, erythema-containing spirochetes can spread to the eyelids and conjunctiva of the eye <em>per continuum</em>. In the second phase when spirochetes spread throughout the whole body but have a predilection for nerve tissue, they occupy cranial nerves. This may also affect the optic nerve, less often oculomotor nerves and the retina. This phase of ocular borreliosis is associated with neuroborreliosis. In this stage, ocular borreliosis usually coexists with meningitis or encephalitis.</p> <p>In addition to the history and clinical picture of Lyme disease, accurate diagnoses based on commercially available serological tests are fundamentally important in Poland. This article describes three phases of Lyme disease. We explain the reasons for its clinical differences in the old and new worlds from an epidemiological perspective. The clinical picture, treatment, and prognosis of Lyme disease are discussed.</p> Piotr Borkowski Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 96 102 10.24292/01.OT.300620.2 Sleep apnea and dry eye: how sleep apnea affects the eye surface https://journalsmededu.pl/index.php/ophthatherapy/article/view/1037 <p><strong>Purpose</strong>: The purpose of this study was to determine the presence of dry eye disease and possible treatment options in patients with obstructive sleep apnea and continuous positive airway pressure.</p> <p><strong>Materials and methods</strong>: A total of 72 patients (midlife age) with obstructive sleep apnea and continuous positive airway pressure therapy underwent a comprehensive eye examination. Fluorescein staining of the anterior ocular surface and tear break-up test were performed. All of the patients who were diagnosed with dry eye disease received personalized therapy. One month later, re-examination was performed using the same methodology and clinical settings.</p> <p><strong>Results</strong>: On the first examination, 48 of 72 patients (66.67%) were diagnosed with dry eye disease. Floppy eyelid syndrome was reported in 26 patients (54.17%) with dry eye disease. The treatment of 40 patients included artificial tear supplements during the day in combination with high-viscosity topical gels before bedtime. In more severe cases (10.42% of all participants), the application of bandage contact lenses for 3 months was necessary. Because of excessive lid laxity, surgical reconstruction of the eyelids was performed in three patients (6.25%).</p> <p><strong>Conclusions</strong>: A multidisciplinary approach is essential for obstructive sleep apnea. Practitioners from different specialties must be well acquainted with risk factors, signs, and symptoms. The early detection of dry eye disease in patients with obstructive sleep apnea and appropriate treatments are important for improving the quality of life in this patient group.</p> Catherina M. Bommert Christina N. Grupcheva Mladena N. Radeva Dimitar I. Grupchev Maria R. Boyadzieva Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc/4.0/ 2020-06-30 2020-06-30 7 2 103 107 10.24292/01.OT.300620.3 Current and novel strategies for the treatment for active thyroid orbitopathy https://journalsmededu.pl/index.php/ophthatherapy/article/view/1038 <p>Graves’ ophthalmopathy is a consequence of an autoimmune orbital reaction that is caused by an antigen or antigens that are common to the thyroid and orbit. This review discusses the pathogenesis of thyroid orbitopathy, current treatment strategies, and new treatment options for both hyperthyroidism and the active phase of ophthalmopathy. The traditional strategy for treating Graves’ ophtalmopathy involves immunosuppressive therapy with steroids, orbital radiation therapy, and surgical decompression. New treatment options include the use of drugs that modulate specific cellular proteins that are involved in orbital autoimmune pathways. These include monoclonal antibodies, cytokine inhibitors, and selective immunosuppressants.</p> Joanna Wierzbowska Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 108 115 10.24292/01.OT.300620.4 High-frequency deep sclerotomy: a minimally invasive surgical option for the treatment of open-angle glaucoma https://journalsmededu.pl/index.php/ophthatherapy/article/view/1039 <p><strong>Purpose</strong>: To investigate the safety and efficacy of high-frequency deep sclerotomy combined with phacoemulsification in open-angle glaucoma patients with concomitant cataracts.</p> <p><strong>Materials and methods</strong>: Nine patients (mean age = 77 years) underwent combined high-frequency deep sclerotomy with phacoemulsification. The main outcome measures were intraocular pressure and the number of ocular hypotensive eyedrops. The results are presented as arithmetic means and standard deviations. The data were analyzed using Student’s <em>t</em>-test. Values of <em>p</em> &lt; 0.05 were considered statistically significant.</p> <p><strong>Results</strong>: Mean preoperative intraocular pressure was 23.56 ± 2.7 mmHg. After 6 months, the follow-up average intraocular pressure was 16.89 ± 1.54 mmHg. Four patients did not require any topical glaucoma medication until their last follow-up. Five patients were able to reduce the number of intraocular pressure-lowering medications. The number of glaucoma medications was 2.44 ± 0.53 and 0.67 ± 0.71 before and after surgery, respectively. No serious complications were observed during the surgical procedure itself or in the postoperative period, with the exception of mild intraoperative hyphema.</p> <p><strong>Conclusion</strong>: Intraocular pressure after surgery was significantly lower than at baseline. A substantial proportion of patients was able to discontinue or reduce intraocular pressure-lowering medications. High-frequency deep sclerotomy combined with cataract surgery is a safe and effective minimally invasive procedure for the treatment of open-angle glaucoma.</p> Piotr Jurowski Monika Chwiałkowska-Karam Łukasz Konopka Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 116 121 10.24292/01.OT.300620.5 The use of laser therapy in retinal diseases: Part I. Laser therapy methods https://journalsmededu.pl/index.php/ophthatherapy/article/view/1040 <p>Retinal diseases account for the vast majority of ophthalmologic disorders. Over recent years, laser-based approaches have been successfully used for treatment. Despite the introduction of other potentially innovative, beneficial, and successful therapeutic methods, lasers are still considered the gold standard. This review discusses the spectrum of currently available laser methods and new insights into novel perspectives and techniques of the laser management of retinal disorders. This review is divided into three sections. First, we present the methodology and spectrum of laser-based techniques. Second, we conducted a literature review to investigate existing knowledge of the laser management of diabetic retinopathy, diabetic macular edema, and vascular retinal disorders. Third, we outline the principles that guide the laser treatment of retinal tears, retinal degeneration, retinopathy of prematurity, age-related macular degeneration, and other retinal diseases.</p> Katarzyna Warzecha Agnieszka Tronina Erita Filipek Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 123 127 10.24292/01.OT.300620.6 Dacryocystectomy as a treatment alternative for chronic recurrent dacryocystitis in elderly patients: case series study https://journalsmededu.pl/index.php/ophthatherapy/article/view/1014 <p>Dacryocystectomy is a procedure that involves complete surgical extirpation of the lacrimal sac. It was first described by Woolhouse in 1724 and became the gold standard for the management of lacrimal system obstruction and dacryocystitis before the advent of dacryocystectomy. Many minimally invasive methods are currently available to treat lacrimal disorders, but there are several specific indications for dacryocystectomy, such as malignant lacrimal sac tumors.</p> <p>Generally, the procedure is performed under local anesthesia, which avoids risks that are associated with general anesthesia or sedation in ailing or elderly patients. Dacryocystectomy can also also avoid skin scars. In 2013, Shams and Selva were the first to perform endoscopic dacryocystectomy.</p> <p>This article discusses indications, contraindications, goals, techniques, and complications of dacryocystectomy.</p> Anna Kwiecińska Małgorzata Woś Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0 2020-06-10 2020-06-10 7 2 129 134 10.24292/01.OT.220520 ABSolu ultrasound platform: a useful tool for ophthalmological diagnostics https://journalsmededu.pl/index.php/ophthatherapy/article/view/1041 <p>Ultrasound examination of the eyeball has been performed in ophthalmological clinics on an everyday basis for a few decades. During that time, dramatic technological progress has been made, enabling high-resolution ultrasound scans with a large focusing zone. This paper presents the diagnostic possibilities of the new Quantel Medical ABSolu ultrasound platform and its utility in ophthalmological practice.</p> Agnieszka Jaszczuk Maciej Gawęcki Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 136 141 10.24292/01.OT.300620.7 Perspectives of clinical applications of RENEXUS® implants in macular telangiectasia type 2 https://journalsmededu.pl/index.php/ophthatherapy/article/view/1042 <p>The intraocular RENEXUS® implant, manufactured by Neurotech Pharmaceuticals, represents a new-generation ophthalmic product with regard to its active chemical substance and mode of the intraocular delivery system. The active compound of the implant, ciliary neurotrophic factor (CNTF), is produced by human retinal pigment epithelium cells that are encapsulated within the device. Ciliary neurotrophic factor has protective effects on retinal cells that help delay their degeneration in chronic retinal degenerative disorders and cases of prolonged ischemia. RENEXUS® implants may be useful for the treatment of macular telangiectasia type 2, retinitis pigmentosa, glaucoma, neuropathy, anterior ischemic neuropathy, and age-related macular degeneration. The active time of CNTF secretion after implantation is approximately 5 years.</p> <p>Intraocular RENEXUS® implants were evaluated in a Phase II clinical trial and have now been tested in a double-blind placebo-controlled clinical trial of macular telangiectasia type 2.</p> Agnieszka Nowosielska Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 142 147 10.24292/01.OT.300620.8 Decrease in reporting rates of patients with eye diseases during the COVID-19 pandemic and the consequences of this phenomenon – one-center's experiences https://journalsmededu.pl/index.php/ophthatherapy/article/view/1043 <p>The SARS-CoV-2 pandemic has significantly impacted the activities of medical entities and patients’ confidence in them. In our ward, we observed a dramatic decrease in patients’ reporting rates for both scheduled visits and unfortunately emergencies. This has had serious consequences for the success of the healing process. This paper presents statistical data from our ward and recent cases in which a patient's delay in seeking medical help could pose a serious threat to vision.</p> Aleksandra Świerczyńska Małgorzata Woś Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 149 154 10.24292/01.OT.300620.9 Contact lens practice in the times of coronavirus https://journalsmededu.pl/index.php/ophthatherapy/article/view/1044 <p>The highly contagious virus SARS-CoV-2 that causes the serious respiratory disease COVID-19 has posed a tremendous challenge to our daily optometric and ophthalmologic contact lens practice.</p> <p>The pandemic is still evolving. Its impact on public health has been significant and intensified and will result in significant economic and social changes. In the time of coronavirus, contactology is undoubtedly becoming more difficult. We should focus on both safety and the personalization of procedures and solutions that are offered to correct vision defects. Nevertheless, we should remember that ophthalmologic and optometric tests that are performed in accordance with epidemiological guidelines are not associated with a higher risk of SARS-CoV-2 infection.</p> Anna M. Ambroziak Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 155 160 10.24292/01.OT.300620.10 Coronavirus and the safety of ophthalmic procedures. Frequently asked questions https://journalsmededu.pl/index.php/ophthatherapy/article/view/1045 <p>Interview with prof. dr. hab. n. med. Marek Rękas, Polish national consultant for ophthalmology</p> Marek Rękas Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 161 167 10.24292/01.OT.300620.11 Summer, coronavirus and dry eye syndrome – effective treatments https://journalsmededu.pl/index.php/ophthatherapy/article/view/1050 <p>Since December, the COVID-19 pandemic has been affecting many people. Today we live in a different reality. However, despite the lethal threat, we still need to help patients with various medical problems. Often people with dry eye syndrome visit the ophthalmology’ consulting room. It’s usually not a serious complication, but it can severely hinder patients' lives and, in exceptional cases, ruin their vision. The article will present the symptoms of dry eye syndrome, causes and effective treatments. There are also discussed: the problem of COVID-19 as a disease entity, ocular symptoms whom may cause and the incidence of eye symptoms among people with this disease. In addition it will be described the connection between coronavirus and dry eye syndrome.</p> Marta Misiuk-Hojło Grzegorz Jasina Copyright (c) 2020 Medical Education sp. z o.o. https://creativecommons.org/licenses/by-nc-nd/4.0/ 2020-06-30 2020-06-30 7 2 168 172 10.24292/01.OT.300620.12