Biwalirudyna – bezpośredni inhibitor trombiny. Mechanizm działania i wskazania w kardiologii Artykuł przeglądowy

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Marek Postuła
Agnieszka Strzelak

Abstrakt

Dokładne zrozumienie mechanizmów hemostazy oraz ograniczeń związanych ze stosowaniem dostępnych leków przeciwkrzepliwych doprowadziło do wynalezienia wielu nowych grup leków, których działanie opiera się na specyficznym hamowaniu procesu krzepnięcia. Bezpośrednie inhibitory trombiny są nową klasą leków, których mechanizm działania związany jest z bezpośrednim zahamowaniem aktywności trombiny i blokowaniem jej interakcji z substratami. Biwalirudyna jest obecnie jedynym przedstawicielem inhibitorów trombiny, którego stosowanie w ramach przezskórnych zabiegów naczyniowych uzasadnione jest licznymi dowodami. Biwalirudyna to syntetyczny analog hirudyny, który odwracalnie wiąże się z trombiną. Wśród czynników związanych z niewielkim ryzykiem krwawień w porównaniu z innymi inhibitorami trombiny wymienia się odwracalne zahamowanie trombiny, krótki okres półtrwania oraz częściowe wydalanie przez nerki.

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Postuła , M., & Strzelak , A. (2008). Biwalirudyna – bezpośredni inhibitor trombiny. Mechanizm działania i wskazania w kardiologii. Kardiologia W Praktyce, 2(1), 22-28. Pobrano z https://journalsmededu.pl/index.php/kwp/article/view/1695
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